Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Homologie
C, M
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Immunogène
This BMPR1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 472-502 amino acids from the C-terminal region of human BMPR1B.
BMPR1B
Reactivité: Humain, Souris
ELISA, IHC
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
WB: 1:1000. IHC-P: 1:50~100
Restrictions
For Research Use only
Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C,-20 °C
Stockage commentaire
Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Date de péremption
6 months
Srikanth, Kim, Das, Kessler: "BMP signaling induces astrocytic differentiation of clinically derived oligodendroglioma propagating cells." dans: Molecular cancer research : MCR, Vol. 12, Issue 2, pp. 283-94, (2014) (PubMed).
Kan, Liu, McGuire, Berger, Awatramani, Dymecki, Kessler: "Dysregulation of local stem/progenitor cells as a common cellular mechanism for heterotopic ossification." dans: Stem cells (Dayton, Ohio), Vol. 27, Issue 1, pp. 150-6, (2009) (PubMed).
Nicholls, Harrison, Gilchrist, Farnworth, Stanton: "Growth differentiation factor 9 is a germ cell regulator of Sertoli cell function." dans: Endocrinology, Vol. 150, Issue 5, pp. 2481-90, (2009) (PubMed).
Antigène
BMPR1B
(Bone Morphogenetic Protein Receptor, Type IB (BMPR1B))
anticorps ALK6, anticorps BMPR-IB, anticorps FecB, anticorps alk-6, anticorps alk6, anticorps cdw293, anticorps alk6b, anticorps zgc:172219, anticorps BMPR1B, anticorps AI385617, anticorps ALK-6, anticorps AV355320, anticorps Acvrlk6, anticorps Alk6, anticorps BMPR-1B, anticorps CFK-43a, anticorps SKR6, anticorps BR1b, anticorps alk6tr, anticorps bmpr1b, anticorps zALK-6, anticorps zgc:92220, anticorps CDw293, anticorps BMP15, anticorps BMPRIB, anticorps RPK-1, anticorps bone morphogenetic protein receptor type 1B, anticorps bone morphogenetic protein receptor, type IBb, anticorps bone morphogenetic protein receptor, type 1B, anticorps bone morphogenetic protein receptor, type IBa, anticorps BMPR1B, anticorps bmpr1b, anticorps bmpr1bb, anticorps Bmpr1b, anticorps bmpr1ba
Sujet
The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.