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Caspase 8 anticorps

CASP8 Reactivité: Humain, Souris WB, EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN499575
  • Antigène Voir toutes Caspase 8 (CASP8) Anticorps
    Caspase 8 (CASP8)
    Reactivité
    • 139
    • 70
    • 63
    • 23
    • 16
    • 16
    • 10
    • 1
    • 1
    • 1
    Humain, Souris
    Hôte
    • 130
    • 26
    • 6
    • 2
    Lapin
    Clonalité
    • 127
    • 36
    Polyclonal
    Conjugué
    • 99
    • 16
    • 11
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp Caspase 8 est non-conjugé
    Application
    • 144
    • 50
    • 44
    • 39
    • 27
    • 26
    • 25
    • 21
    • 20
    • 18
    • 8
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificité
    Caspase-8 antibody was raised against a 15 amino acid peptide from near the carboxy terminus human caspase-8 isoform E.
    Purification
    Affinity chromatography purified via peptide column
    Immunogène
    Virus Casp-8 / FLICE / MACH / Mch5 (E) Peptide
    Isotype
    IgG
    Top Product
    Discover our top product CASP8 Anticorps primaire
  • Indications d'application
    ELISA. Western Blot: Casp-8 antibody can be used for the detection of Caspase-8 at 0.5 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C.
  • Antigène
    Caspase 8 (CASP8)
    Autre désignation
    Caspase-8 (CASP8 Produits)
    Synonymes
    anticorps casp8-A, anticorps xCaspase-8, anticorps casp8, anticorps CASP8, anticorps CASP-8, anticorps FLICE, anticorps MACH, anticorps Mch5, anticorps ALPS2B, anticorps CAP4, anticorps Casp-8, anticorps MCH5, anticorps caspase-8, anticorps zgc:92075, anticorps caspase 8 L homeolog, anticorps death related ced-3/Nedd2-like protein, anticorps caspase 8, anticorps caspase-8, anticorps caspase-8-like, anticorps caspase 8, apoptosis-related cysteine peptidase, anticorps casp8.L, anticorps LOC661095, anticorps CASP8, anticorps LOC5563818, anticorps casp8, anticorps LOC100222284, anticorps Casp8
    Sujet
    Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens (reviewed in 1 and 2). The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death (reviewed in 3). Caspase-8 is an initiator caspase that was identified as a member of the Fas/APO-1 death-inducing signaling complex (4). The adaptor molecule FADD couples procaspase-8 to the Fas receptor death domain, subsequent oligomerization promotes procaspase-8 autoactivation (reviewed in 5). FLIP, a catalytically inactive caspase-8-like molecule inhibits these interactions and thus can inhibit apoptosis (6). This antibody will only detect isoform E of caspase-8.Synonyms: Apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, CASP-8, CASP8, FADD-homologous ICE/CED-3-like protease, FADD-like ICE, ICE-like apoptotic protease 5, MCH5, MORT1-associated CED-3 homolog
    ID gène
    841
    NCBI Accession
    NP_001219
    UniProt
    Q14790
    Pathways
    Apoptose, Caspase Cascade in Apoptosis, Signalisation TLR, Activation of Innate immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades
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