Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)
Homologie
Ha, M, Rat
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Immunogène
This HMGA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 64-93 amino acids from the C-terminal region of human HMGA1.
HMGA1
Reactivité: Humain
IHC, IF
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
IF: 1:10~50. WB: 1:1000. WB: 1:1000. FC: 1:10~50
Restrictions
For Research Use only
Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C,-20 °C
Stockage commentaire
Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Date de péremption
6 months
Liu, Zhang, Li, Ding, Tu, Zhou, Qi, Chen, Sun: "Let-7a inhibits growth and migration of breast cancer cells by targeting HMGA1." dans: International journal of oncology, Vol. 46, Issue 6, pp. 2526-34, (2015) (PubMed).
anticorps HMG-R, anticorps HMGA1A, anticorps HMGIY, anticorps Hmgi, anticorps Hmgiy, anticorps hmga1, anticorps hmgiy, anticorps wu:fb12b06, anticorps wu:fb18f11, anticorps wu:fc19f01, anticorps wu:fi38b05, anticorps zgc:85677, anticorps AL023995, anticorps Hmga1a, anticorps Hmga1b, anticorps Hmgy, anticorps HMG-I(Y), anticorps HMG-Y, anticorps HMGA1, anticorps zgc:153948, anticorps high mobility group AT-hook 1, anticorps high mobility group protein HMG-I/HMG-Y, anticorps high mobility group AT-hook 1a, anticorps high mobility group AT-hook 1b, anticorps HMGA1, anticorps Hmga1, anticorps TSC_c24220, anticorps hmga1a, anticorps LOC705105, anticorps hmga1b
Sujet
HMGA1 encodes a non-histone protein involved in many cellular processes, including regulation of inducible gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of A+T-rich regions in double-stranded DNA. It has little secondary structure in solution but assumes distinct conformations when bound to substrates such as DNA or other proteins. The encoded protein is frequently acetylated and is found in the nucleus.