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- Antigène Voir toutes RUNX1T1 Anticorps
- RUNX1T1 (Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1))
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp RUNX1T1 est non-conjugé
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Application
- Immunohistochemistry (IHC)
- Purification
- Purified by antigen-specific affinity chromatography.
- Immunogène
- Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human AML1-MTG8(acute myelogenous leukemia 1 translocation 1 protein isoform MTG8c)
- Top Product
- Discover our top product RUNX1T1 Anticorps primaire
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- Indications d'application
- ELISA, Western blotting: 1µg/ml for 2hrs.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- This antibody is stored in PBS, 50% glycerol
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
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The oncogenic fusion protein RUNX1-CBFA2T1 supports proliferation and inhibits senescence in t(8;21)-positive leukaemic cells." dans: BMC cancer, Vol. 4, pp. 44, (2004) (PubMed).
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The oncogenic fusion protein RUNX1-CBFA2T1 supports proliferation and inhibits senescence in t(8;21)-positive leukaemic cells." dans: BMC cancer, Vol. 4, pp. 44, (2004) (PubMed).
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- Antigène
- RUNX1T1 (Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1))
- Autre désignation
- AML1-MTG8 (RUNX1T1 Produits)
- Synonymes
- anticorps MTG8, anticorps si:ch211-232j17.1, anticorps wu:fi14b07, anticorps zgc:154044, anticorps AML1T1, anticorps CBFA2T1, anticorps CDR, anticorps ETO, anticorps ZMYND2, anticorps Cbfa2t1h, anticorps Cbfa2t1, anticorps runt-related transcription factor 1; translocated to, 1 (cyclin D-related), anticorps RUNX1 translocation partner 1 L homeolog, anticorps RUNX1 translocation partner 1, anticorps runx1t1, anticorps runx1t1.L, anticorps RUNX1T1, anticorps Runx1t1
- Sujet
- AML1-MTG8(acute myelogenous leukemia 1 translocation 1 protein isoform MTG8c) is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8,21)(q22,q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Several transcript variants encoding multiple isoforms have been found for this gene.
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