AXL anticorps (Extracellular)

N° du produit ABIN965630

Détail du produit anti-AXL anticorps

Antigène: AXL (AXL Receptor tyrosine Kinase (AXL))

Épitope: Extracellular

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp AXL est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Purification: Ascitic fluid

Immunogène: Purified recombinant extracellular fragment of human AXL fused with hIgGFc tag expressed in HEK293 cell line.

Clone: 7E10

Isotype: IgG1

Information d'application

Indications d'application: Western Bloting: 1/500 - 1/2000.
Immunofluorescence: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Stockage

Format: Liquid

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Références pour anticorps anti-AXL (ABIN965630)

Green, Ikram, Vyas, Patel, Proby, Ghali, Leigh, OToole, Storey: "Overexpression of the Axl tyrosine kinase receptor in cutaneous SCC-derived cell lines and tumours." dans: British journal of cancer, Vol. 94, Issue 10, pp. 1446-51, (2006) (PubMed).

Vajkoczy, Knyazev, Kunkel, Capelle, Behrndt, von Tengg-Kobligk, Kiessling, Eichelsbacher, Essig, Read, Erber, Ullrich: "Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survival." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 15, pp. 5799-804, (2006) (PubMed).

Détails sur AXL

Antigène: AXL (AXL Receptor tyrosine Kinase (AXL))

Autre désignation: AXL (AXL Produits)

Synonymes: anticorps JTK11, anticorps UFO, anticorps AI323647, anticorps Ark, anticorps Tyro7, anticorps Ufo, anticorps AXL receptor tyrosine kinase, anticorps Axl receptor tyrosine kinase, anticorps AXL, anticorps Axl

Sujet: AXL receptor tyrosine kinase, also known as UFO, JTK11. Entrez Protein NP_001690. It is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. Alternatively spliced transcript variants encoding different isoforms have been identified.
Synonyms: UFO, JTK11

Poids moléculaire: 97.4kDa

ID gène: 558

Pathways: Signalisation RTK, Cellular Response to Molecule of Bacterial Origin