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anti-Rat (Rattus) CYLD Anticorps:
anti-Mouse (Murine) CYLD Anticorps:
anti-Human CYLD Anticorps:
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Mouse (Murine) Polyclonal CYLD Primary Antibody pour WB - ABIN374832
Massoumi, Chmielarska, Hennecke, Pfeifer, Fässler: Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling. dans Cell 2006
Human Polyclonal CYLD Primary Antibody pour ICC, IF - ABIN252428
Moranta, Regueiro, March, Llobet, Margareto, Larrarte, Larrate, Garmendia, Bengoechea: Klebsiella pneumoniae capsule polysaccharide impedes the expression of beta-defensins by airway epithelial cells. dans Infection and immunity 2010
The crystal structures representing the catalytic states of zebrafish CYLD for Met1 (Montrer DNMT1 Anticorps)- and Lys63-linked Ub chains and two distinct precatalytic states for Met1 (Montrer DNMT1 Anticorps)-linked chains are presented.
Our findings underscore a critical tumor-suppressing role for functional intestinal epithelial CYLD in colitis-associated carcinogenesis
Deubiquitinase CYLD negatively regulates MyD88 (Montrer MYD88 Anticorps)-mediated signaling by directly interacting with MyD88 (Montrer MYD88 Anticorps) and deubiquitinating nontypeable Haemophilus influenzae (NTHi)-induced K63-linked polyubiquitination of MyD88 (Montrer MYD88 Anticorps) at lysine 231.
CYLD interrupts the ERK (Montrer EPHB2 Anticorps)- and p38 (Montrer CRK Anticorps)-/AP-1 (Montrer JUN Anticorps) and c-Myc (Montrer MYC Anticorps) pathways to suppress Nrf2 (Montrer NFE2L2 Anticorps)-operated antioxidative capacity, thereby enhancing oxidative stress in the heart.
Our data demonstrate that inefficient negative selection in the thymus of CYLD(ex7/8) mice result from a defect in mTEC maturation.
The deubiquitinating enzyme CYLD controls apical docking of basal bodies in ciliated epithelial cells.
Data show that the in utero death of NF-NF (Montrer NFASC Anticorps)-kappaB (Montrer NFKB1 Anticorps) essential modulator (NEMO (Montrer IKBKG Anticorps)) and cylindromatosis protein double mutant mice is mediated by TNF (Montrer TNF Anticorps) receptor 1 (TNFR1 (Montrer TNFRSF1A Anticorps)) signaling and can be rescued by TNFR1 (Montrer TNFRSF1A Anticorps) deficiency.
CYLD is a central regulator of apoptotic cell death in murine hepatocytes by controlling NF-kappaB (Montrer NFKB1 Anticorps) dependent anti-apoptotic signaling.
In contrast to full-length CYLD, the immune function of short splice variant CYLD (sCYLD) is insufficiently described. To explore sCYLD's function in infection, investigated whether dendritic cell-specific sCYLD regulates the pathogenesis of listeriosis.
The ciliary function of CYLD is partially attributed to its deconjugation of the polyubiquitin (Montrer UBB Anticorps) chain from centrosomal protein of 70 kDa (Cep70 (Montrer CEP70 Anticorps)), a requirement for Cep70 (Montrer CEP70 Anticorps) to interact with gamma-tubulin (Montrer TUBG1 Anticorps) and localize at the centrosome.
CYLD negatively regulates nontypeable Haemophilus influenzae-induced IL-8 (Montrer IL8 Anticorps) expression via MKP-1 (Montrer DUSP1 Anticorps)-dependent inhibition of ERK (Montrer EPHB2 Anticorps).
Low CYLD expression is associated with hepatocellular carcinoma.
miR20a directly repressed the expression of CYLD, leading to activation of the NFkappaB (Montrer NFKB1 Anticorps) pathway and the downstream targets, livin (Montrer BIRC7 Anticorps) and survivin (Montrer BIRC5 Anticorps), which potentially induced GC chemoresistance.
Data show that cylindromatosis (CYLD) overexpression and livin (Montrer BIRC7 Anticorps) knockdown might improve gemcitabine chemosensitivity by decreasing autophagy and increasing apoptosis in bladder cancer (BCa (Montrer BLNK Anticorps)) cells.
aberrantly expressed miR (Montrer MLXIP Anticorps)-130b may regulate cell apoptosis and proliferation of human gastric cancer cells via CYLD, which appears to be a promising therapeutic target for gastric cancer
These results demonstrate the involvement of histone deacetylases in the down regulation of Cyld expression in hepatocellular carcinoma cells.
Novel CYLD germline mutations c.1821_1826+1delinsCT/L607Ffs*9, c.2666A>T/p.D889V and c.2712delT/p.905Kfs*8 were identified in unrelated Brooke-Spiegler Syndrome patients.
Study founds the levels of CYLD and SMAD7 (Montrer SMAD7 Anticorps) significantly decreased in oral squamous cell carcinoma (OSSC) cells and proposes a model that CYLD suppresses OSCC metastases through SMAD7 (Montrer SMAD7 Anticorps). Downregulation of CYLD appears to directly contribute to the distal metastases of primary OSCC and subsequently poor prognosis.
Haplotype analysis was performed for the patients with multiple familial trichoepithelioma type 1, patients with familial cylindromatosis and a patient with Brooke-Spiegler syndrome, all of whom carry the same heterozygous nonsense CYLD mutation.
Ultraviolet radiation induced CYLD translocation from the cytoplasm to microtubules, posttranslational modification and degradation in a proteasome-independent manner.
This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
cylindromatosis (turban tumor syndrome)
, probable ubiquitin carboxyl-terminal hydrolase CYLD-like
, ubiquitin carboxyl-terminal hydrolase CYLD
, deubiquitinating enzyme CYLD
, ubiquitin thioesterase CYLD
, ubiquitin thiolesterase CYLD
, ubiquitin-specific-processing protease CYLD
, probable ubiquitin carboxyl-terminal hydrolase CYLD
, retinitis pigmentosa 1 homolog
, ubiquitin specific peptidase like 2