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anti-Mouse (Murine) BIK Anticorps:
anti-Human BIK Anticorps:
anti-Rat (Rattus) BIK Anticorps:
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Human Monoclonal BIK Primary Antibody pour IP, WB - ABIN967566
Boyd, Gallo, Elangovan, Houghton, Malstrom, Avery, Ebb, Subramanian, Chittenden, Lutz: Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins. dans Oncogene 1995
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Human Polyclonal BIK Primary Antibody pour ICC, ELISA - ABIN1001872
Lockshin, Osborne, Zakeri: Cell death in the third millennium. dans Cell death and differentiation 2000
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Human Polyclonal BIK Primary Antibody pour IHC (fro), WB - ABIN2477650
Unsicker, Stögbauer: Screening of adrenal medullary neuropeptides for putative neurotrophic effects. dans International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 1992
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Human Polyclonal BIK Primary Antibody pour IHC (p), WB - ABIN388114
Gillissen, Essmann, Graupner, Stärck, Radetzki, Dörken, Schulze-Osthoff, Daniel: Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway. dans The EMBO journal 2003
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Human Polyclonal BIK Primary Antibody pour WB - ABIN223382
Chen, Huang, Wang: Deficiency of Bim in dendritic cells contributes to overactivation of lymphocytes and autoimmunity. dans Blood 2007
Human Polyclonal BIK Primary Antibody pour ICC, ELISA - ABIN1031274
Chen, Zhou, Zhang, Leng, Pei, Lin, Jones, Orlowski, Dai, Grant: Targeting SQSTM1/p62 induces cargo loading failure and converts autophagy to apoptosis via NBK/Bik. dans Molecular and cellular biology 2014
These studies suggest a link between Bik-mediated caspase (Montrer CASP3 Anticorps) activation and cleavage of viral proteins.
OPN (Montrer SPP1 Anticorps) induces oxidative stress via the involvement of mitochondria and NOX-4 (Montrer NOX4 Anticorps). It may affect mitochondrial morphology and integrity, at least in part, via the involvement of BIK.
Findings identify novel cross talk between autophagy and apoptosis, wherein targeting SQSTM1/p62 (Montrer SQSTM1 Anticorps) converts cytoprotective autophagy to an inefficient form due to cargo loading failure, leading to NBK/Bik accumulation, which triggers apoptosis.
Src (Montrer SRC Anticorps) tyrosine kinase (Montrer TYRO3 Anticorps) inhibits apoptosis through the Erk1/2 (Montrer MAPK1/3 Anticorps)- dependent degradation of the death accelerator Bik.
The Bik protein, even in combination with Noxa (Montrer PMAIP1 Anticorps), is not a potent suppressor of c-Myc (Montrer MYC Anticorps)-driven tumourigenesis or critical for chemotherapeutic drug-induced killing of Myc (Montrer MYC Anticorps)-driven tumours.
BIKDD, a constitutively active mutant form of proapoptotic gene, BIK, effectively induces apoptosis of breast cancer cells and synergizes with lapatinib.
Blk has been mapped to chromosome 15 and overexpressed in transitional B cells of A/WySnJ mice, which demonstrate a cell-autonomous defect leading to excessive apoptosis.
any function of Bik in programmed cell death and stress-induced apoptosis must overlap that of other BH3-only (Montrer BBC3 Anticorps) proteins
Data show that Bik and Bim (Montrer BCL2L11 Anticorps) share the role of eliminating supernumerary germ cells during the first wave of spermatogenesis, a process vital for normal testicular development.
Targeted expression of BikDD, a potent proapoptotic gene driven by CCKAR (Montrer CCKAR Anticorps)-VISA (Montrer MAVS Anticorps), exhibited antitumor effects on pancreatic cancer and prolonged survival in multiple xenograft and syngeneic mouse models of pancreatic tumors with virtually no toxicity
BIK significantly contributes to DNA damage-induced mitochondrial apoptosis in HCT-116 wt cells upstream of the second peak of ROS (Montrer ROS1 Anticorps) production, BAX (Montrer BAX Anticorps) and BAK (Montrer BAK1 Anticorps) activation, cytochrome c (Montrer CYCS Anticorps) release and caspase (Montrer CASP3 Anticorps) activation.
our data demonstrated that suppression of BIK in ER-positive MCF-7 cells prevents the cytotoxic effect of TAM (Montrer CCNA1 Anticorps) and favors a more aggressive phenotype, due to the molecular change of different pathways
HCV RNA replication and release were significantly suppressed in BIK-depleted cells and over-expression of the RNA-dependent RNA polymerase, NS5B, was able to induce BIK expression
BikDDA, a novel mutant of Bik, showed a prolonged half-life and enhanced pro-apoptotic ability in triple-negative breast cancer cells compared with BikDD.
Authors show that human herpesvirus 4 EBNA2 represses BIK in B-cell lymphoma-derived cell lines and that this host-virus interaction can inhibit the proapoptotic effect of transforming growth factor beta1.
Data suggest BIK expression in tumor cells is not subject to direct regulation by MAP kinase (Montrer MAPK1 Anticorps) signaling; BIK expression appears to be cell-cycle-dependent and increases in G1 cell-cycle arrest which results from inhibition of MAP kinase (Montrer MAPK1 Anticorps) signaling.
BIK/NBK gene expression may have important clinical implications and provide predictive, prognostic or therapeutic marker in breast cancer patients
Src (Montrer SRC Anticorps) tyrosine kinase (Montrer TXK Anticorps) inhibits apoptosis through the Erk1/2 (Montrer MAPK1/3 Anticorps)- dependent degradation of the death accelerator Bik.
The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins.
BCL2-interacting killer (apoptosis-inducing)
, BCL2-interacting killer
, apoptosis inducer NBK
, bcl-2-interacting killer
, bik-like killer protein
, apoptosis-inducing NBK