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Aperçu des produits pour TAR DNA Binding Protein (TARDBP) Kits ELISA

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TAR DNA Binding Protein Kits ELISA (TARDBP)
Chez sont 27 TAR DNA Binding Protein (TARDBP) Kits ELISA de 10 de différents fournisseurs disponibles. De plus, nous expédions TAR DNA Binding Protein Anticorps (236) et TAR DNA Binding Protein Protéines (14) et beaucoup plus de produits pour cette protéine. Un total de 292 TAR DNA Binding Protein produits sont actuellement listés.
1190002A23Rik, ALS10, C85084, DKFZp459I2127, tardbp, TDP-43, Tdp43, wu:fb77f02, wu:fc52g10

Plus Kits ELISA pour TAR DNA Binding Protein partenaires d'interaction

Human TAR DNA Binding Protein (TARDBP) interaction partners

  1. The aim of this review will be to provide a general overview of TDP-43 and FUS/TLS (Montrer FUS Kits ELISA) proteins and to highlight their physiological functions--{REVIEW}

  2. Increased cytoplasmic TARDBP mRNA in affected spinal motor neurons in amyotrophic lateral sclerosis is caused by abnormal autoregulation of TDP-43.

  3. Findings suggest a mechanism in which retrotransposable element (RTE) activity contributes to neurodegeneration in TAR DNA-binding protein 43 (TDP-43)-mediated diseases such as Amyotrophic lateral sclerosis (ALS (Montrer IGFALS Kits ELISA)) and frontotemporal lobar degeneration (FTLD).

  4. Possible role of deregulated DNA binding function of TDP-43 in ALS.

  5. These data suggest that Familial Amyotrophic Lateral Sclerosis-linked PFN1 (Montrer PFN1 Kits ELISA) mutations exacerbate TDP-43-induced neurodegeneration in a gain-of-function manner, possibly by shifting the localization of TDP-43 from nuclei to cytoplasm.

  6. Data suggest that transitions of TDP-43 among soluble, droplet, and aggregate phases are involved in pathological aggregation; TDP-43 prion (Montrer PRNP Kits ELISA)-like domain appears to wobble at a cusp of the protein folding energy landscape where any number of factors can tip the balance and trigger the conversion from its native function to its pathological one. [REVIEW]

  7. Secreted PGRN (Montrer GRN Kits ELISA) is incorporated into cells via sortilin (Montrer SORT1 Kits ELISA) or cation-independent mannose 6-phosphate receptor (Montrer IGF2R Kits ELISA), and facilitated the acidification of lysosomes and degradation of CTSDmat. Moreover, the change of PGRN (Montrer GRN Kits ELISA) levels led to a cell-type-specific increase of insoluble TDP-43. In the brain tissue of FTLD-TDP patients with PGRN (Montrer GRN Kits ELISA) deficiency, CTSD (Montrer CTSD Kits ELISA) and phosphorylated TDP-43 accumulated in neurons

  8. Various degrees of TDP-43 cytoplasmic accumulation and nuclear TDP-43 depletion were achieved and the resulting cellular viability was evaluated, leading to a quantitative global analysis on the relative effects of LOF and GOF on the overall cytotoxicity.

  9. results from this study suggest that TDP-43 represents a translational repressor not only for specific mRNAs but for overall translation and that its binding to polyribosomes through RACK1 (Montrer GNB2L1 Kits ELISA) may promote, under conditions inducingAmyotrophic Lateral Sclerosis pathogenesis, the formation of cytoplasmic inclusions.

  10. using an in vitro cellular model, we demonstrated that Drb1 (Montrer RBM45 Kits ELISA) co-localizes with cytoplasmic aggregates mediated by TAR DNA-binding protein 43

Mouse (Murine) TAR DNA Binding Protein (TARDBP) interaction partners

  1. this study suggests hemizygous TDP-43(M337V) mice as a useful animal model to study TDP-43 toxicity and further consolidates mitochondrial TDP-43 as a novel therapeutic target for TDP-43-linked neurodegenerative diseases.

  2. demonstrated that the levels of HSF1 (Montrer HSF1 Kits ELISA) and heat shock proteins are significantly reduced in affected neuronal tissues from a TDP-43 transgenic mouse model of amyotrophic lateral sclerosis and patients with sporadic amyotrophic lateral sclerosis.

  3. The present study identified USP7 (Montrer USP7 Kits ELISA) and TDP-43 as the regulators of CRY1 (Montrer CRY1 Kits ELISA) and CRY2 (Montrer CRY2 Kits ELISA), underscoring the significance of the stability control process of CRY (Montrer CRY2 Kits ELISA) proteins for period determination in the mammalian circadian clockwork.

  4. TDP-43 functions within a network of hnRNP (Montrer HNRNPH2 Kits ELISA) proteins to inhibit the production of a truncated human SORT1 (Montrer SORT1 Kits ELISA) receptor.

  5. Data demonstrate the existence of a physiological decrease of TDP-43/TBPH levels with aging in brain tissue both in wild-type mice and flies, showing that it is an evolutionary conserved phenomenon

  6. This study demonistrated that proprioceptive nerve endings in muscles revealed early and alterations at Ia/II proprioceptive nerve endings in muscle spindles and in the absence of alterations in alpha-motor axons in TDP43(A315T) transgenic mice.

  7. UBQLN2 (Montrer UBQLN2 Kits ELISA) dysregulation in neurons can drive NF-kappaB (Montrer NFKB1 Kits ELISA) activation and cytosolic TDP-43 aggregation.

  8. These findings demonstrate a role for PABPN1 (Montrer PABPN1 Kits ELISA) in rescuing several cytopathological features of TDP-43 proteinopathy by increasing the turnover of pathologic proteins.

  9. identifies DDX58 (Montrer DDX58 Kits ELISA) and MTHFSD as two TDP-43 targets that are misregulated in amyotrophic lateral sclerosis. 1

  10. Valproate Attenuates 25-kDa C-Terminal Fragment of TDP-43-Induced Neuronal Toxicity via Suppressing Endoplasmic Reticulum Stress and Activating Autophagy.

Zebrafish TAR DNA Binding Protein (TARDBP) interaction partners

  1. Data indicate a method for site-directed single nucleotide editing in two disease-related genes, DNA binding protein (Montrer CNBP Kits ELISA) tardbp and RNA binding protein fus (Montrer FUS Kits ELISA).

  2. Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth.

  3. TARDBP and FUS (Montrer FUS Kits ELISA) act in a pathogenic pathway that is independent of SOD1 (Montrer SOD1 Kits ELISA).

TAR DNA Binding Protein (TARDBP) profil antigène

Antigen Summary

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.

Alternative names and synonyms associated with TAR DNA Binding Protein (TARDBP)

  • TAR DNA binding protein (TARDBP) Elisa Kit
  • Tardbp protein (tardbp) Elisa Kit
  • TAR DNA binding protein (tardbp) Elisa Kit
  • TAR DNA binding protein (Tardbp) Elisa Kit
  • TAR DNA-binding protein 43-like (LOC100621383) Elisa Kit
  • 1190002A23Rik Elisa Kit
  • ALS10 Elisa Kit
  • C85084 Elisa Kit
  • DKFZp459I2127 Elisa Kit
  • tardbp Elisa Kit
  • TDP-43 Elisa Kit
  • Tdp43 Elisa Kit
  • wu:fb77f02 Elisa Kit
  • wu:fc52g10 Elisa Kit

Protein level used designations for TARDBP

TAR DNA binding protein , TAR DNA-binding protein 43 , Tardbp protein , TDP-43 , TAR DNA-binding protein-43

100174676 Pongo abelii
457942 Pan troglodytes
713860 Macaca mulatta
778772 Ciona intestinalis
100051482 Equus caballus
100602228 Nomascus leucogenys
380329 Xenopus laevis
419453 Gallus gallus
23435 Homo sapiens
478234 Canis lupus familiaris
540632 Bos taurus
230908 Mus musculus
298648 Rattus norvegicus
325052 Danio rerio
100718595 Cavia porcellus
101114038 Ovis aries
100621383 Sus scrofa
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