Aperçu des produits pour MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) Protéines (MSH2)

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MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) Protéines (MSH2)
Chez www.anticorps-enligne.fr sont 8 MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) (MSH2) Protéines de 1 de différents fournisseurs disponibles. De plus, nous expédions MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) Anticorps (5) et MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) Kits (2) et beaucoup plus de produits pour cette protéine. Un total de 17 MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) produits sont actuellement listés.
Synonymes:
AI788990, ATMSH2, CG7895, COCA1, Dmel\CG7895, DmNK-4, DROHOXHK4, DROHOXNK4, FCC1, HNPCC, HNPCC1, HOX, LCFS2, msh-2, msh2, MUTS homolog 2, NK-4, NK-4/msh-2, NK4, NK4/msh-2, NKX2.5, Tin, tin/NK4, wu:fc06b02, wu:fc13e09, zgc:55333
afficher tous les protéines Gène GeneID UniProt
Souris MSH2 MSH2 17685 P43247
Rat MSH2 MSH2 81709 P54275
Humain MSH2 MSH2 4436 P43246

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Plus protéines pour MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) partenaires d'interaction

Arabidopsis thaliana MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) (MSH2) interaction partners

  1. The expression of AtMutSgamma (MSH7 and MSH2) in Saccharomyces cerevisiae suggest that AtMutSgamma affects yeast genomic stability by recognizing specific mismatches.

  2. The contribution of MutSalpha (MSH2-MSH6) to ultraviolet-induced DNA lesion repair and cell cycle regulation was investigated.

  3. reported that AtMSH2 has a broad range of anti-recombination effects: it suppresses recombination between divergent direct repeats in somatic cells or between homologues from different ecotypes during meiosis

Mouse (Murine) MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) (MSH2) interaction partners

  1. Deletion of the MSH2 C-terminus severely affected the stability of the MSH2/MSH6 (Montrer MSH6 Protéines) heterodimer and consequently strongly attenuated DNA mismatch repair. The C-terminal truncation MSH2 mutant predisposed mice to tumor formation.Mutations deleting the MSH2 C-terminus can therefore unambiguously be considered as pathogenic and a cause of Lynch syndrome.

  2. Normal Msh2-deficient organoids showed increased inheritable transient cyst-like growth, which became independent of R-spondin. intestinal stem cell (ISC) proceeded faster in vitro than in vivo independent of the underlying genotype but more under Mutations in mismatch repair deficiency.

  3. Study shows that MSH2-/- mice develop spontaneous thymic lymphomas.

  4. Data show that in mutS homolog 2 protein Msh2(+/-) mice, azathioprine (Aza) induced a high incidence of microsatellite instability (MSI (Montrer EBP Protéines)) lymphomas in a dose-dependent manner.

  5. In Msh2-/- mice, red meat enhanced survival compared to control (p<0.01) and lowered total tumour burden compared to resistant starch (p<0.167).

  6. Angptl2 (Montrer ANGPTL2 Protéines)-induced inflammation increases susceptibility to microenvironmental changes, allowing increased oxidative stress and decreased Msh2 expression.

  7. Gut (Montrer GUSB Protéines) microbes did not induce colorectal cancer in APC (Montrer APC Protéines)(Min/+)MSH2(-/-) mice through an inflammatory response or the production of DNA mutagens but rather by providing carbohydrate-derived metabolites such as butyrate that fuel hyperproliferation of MSH2(-/-) colon epithelial cells.

  8. MSH2-MSH3 suppresses chromosomal instability and modulates the tumor spectrum in p53 (Montrer TP53 Protéines)-deficient tumorigenesis.

  9. Results suggest that MSH2 is rate limiting for expansion in fragile X (Montrer FMR1 Protéines) premutation mouse model and that MSH2 levels may be a key factor that accounts for tissue-specific differences in expansion risk.

  10. Toxicity, induced by tert (Montrer TERT Protéines)-butyl-hydroperoxide and potassium bromate, differs in base excision repair proficient (Mpg (Montrer MPG Protéines) (+/+), Nth1 (+/+)) and deficient (Mpg (Montrer MPG Protéines) (-/-), Nth1 (-/-)) mouse embryonic fibroblasts following Msh2 knockdown, was examined.

Zebrafish MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) (MSH2) interaction partners

  1. Identification and characterization of novel knockout mutants of the three major MMR (Montrer MRC1 Protéines) genes, mlh1 (Montrer MLH1 Protéines), msh2, and msh6 (Montrer MSH6 Protéines), in zebrafish that develop tumors at low frequencies.

Human MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) (MSH2) interaction partners

  1. MSH2 mutations contribute to colorectal cancer susceptibility in Algerian families with suspected Lynch syndrome.

  2. The data suggest that EZH2 (Montrer EZH2 Protéines)-H3K27me3 regulatory mechanism dynamically changes the expression levels of DNA mismatch repair gene MutS homolog 2, through epigenetic mark H3K27me3.

  3. Genetic changes between MLH1 (Montrer MLH1 Protéines) and MSH2 were significantly positively correlated (p = 0.032). We also noted a positive correlation between genetic changes of MSH2 and DVL3 (Montrer DVL3 Protéines) genes (p = 0.034).

  4. Here we demonstrate that in silico saturation mutagenesis and biophysical calculations of the structural stability of the human mismatch repair protein MSH2 correlate with cellular protein levels, turnover and function. Of 24 different MSH2 variants, some of which are linked to Lynch syndrome, a destabilization of as little as 3 kcal/mol (Montrer DUOXA1 Protéines) is sufficient to cause rapid degradation via the ubiquitin-proteasome pathway.

  5. human Pol alpha interacts with MSH2-MSH6 (Montrer MSH6 Protéines) complex

  6. In colorectal neoplasms, negative expression of the MMR (Montrer MRC1 Protéines) proteins MLH1 (Montrer MLH1 Protéines), MSH2 or MSH6 (Montrer MSH6 Protéines) was seen in 15% (47 of 313) of the patients. Defect MLH1 (Montrer MLH1 Protéines) was most common and detected in 12% of the cases. Defect MLH1 (Montrer MLH1 Protéines) and MSH2 were identified in each patient's normal adjacent mucosa.

  7. unlike MutSbeta, MutSalpha may also act to protect against repeat contractions in the Fmr1 (Montrer FMR1 Protéines) gene

  8. The expression of genes and proteins related to DNA repair mechanism MLH1 (Montrer MLH1 Protéines), MSH2 and ATM (Montrer ATM Protéines) in the normal oral mucosa of chronic smokers was reduced.

  9. The expression of genes and proteins related to DNA repair mechanism MLH1 (Montrer MLH1 Protéines), MSH2 and ATM (Montrer ATM Protéines) in the normal oral mucosa of chronic smokers was reduced.

  10. A total of 201 unique disease-predisposing mismatch repair gene mutations were identified in 369 Lynch syndrome families. These mutations affected MLH1 (Montrer MLH1 Protéines) in 40%, MSH2 in 36%, MSH6 (Montrer MSH6 Protéines) in 18% and PMS2 (Montrer PMS2 Protéines) in 6% of the families.

Fruit Fly (Drosophila melanogaster) MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) (MSH2) interaction partners

  1. Overexpression of Tinman and Pannier resulted in 20% of embryos with ectopic Hand and Sur (Montrer ABCC8 Protéines) expression. By adding MEF2 (Montrer MYEF2 Protéines) alongside Tinman and Pannier, an expansion in expression of Hand and Sur (Montrer ABCC8 Protéines) was observed.

  2. Findings provide mechanistic insight into the brake on myogenesis that occurs during mesoderm specification: twist and tin expression at early stages in turn activate the myogenic inhibitor Him; yet, once Twist or Tin levels decline at mid-embryogenesis, Him is no longer expressed in the mesoderm, and MEF2 (Montrer MYEF2 Protéines)-dependent muscle differentiation can proceed.

  3. Plasticity in Hox/PBC (Montrer DLAT Protéines) interaction modes is a common molecular strategy for shaping Hox transcriptional activities.

  4. The enhancers active in the heart progenitor cells and the heart generally are dependent on tinman gene activity, whereas those active in non-cardiac mesoderm are often bound neutrally by Tinman

  5. Genetic interaction analysis shows that spir functionally interacts with Dorsocross, tin, and pannier to properly specify the cardiac fate.

  6. Tin is a direct regulator of midline in fly heart development.

  7. wg and dpp (Montrer TGFb Protéines) contribute progressively to the elaboration of the expression pattern of the mesoderm-specific homeobox (Montrer PRRX1 Protéines)-containing gene tinman (tin), and the overlap of wg and dpp (Montrer TGFb Protéines) in the presence of tin-expressing cells directs cardiac-specific differentiation

  8. We show that salivary gland posterior migration requires the activities of genes that position the visceral mesoderm precursors, such as heartless, thickveins, and tinman, but does not require a differentiated visceral mesoderm.

  9. one of the major functions of mid and H15 during cardioblast development is the re-activation of tin expression at a stage when the induction of tin by Dpp (Montrer TGFb Protéines) in the dorsal mesoderm has ceased

  10. dSUR is regulated by tinman and plays a protective role against hypoxic stress and pacing-induced heart failure

Profil protéine MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) (MSH2)

Profil protéine

This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) (MSH2)

  • mismatch repair protein (MSH2)
  • DNA mismatch repair protein Msh2 (MSH2)
  • mutS homolog 2 (E. coli) (Msh2)
  • mutS homolog 2 (E. coli) (msh2)
  • mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) (MSH2)
  • tinman (tin)
  • AI788990 Protéine
  • ATMSH2 Protéine
  • CG7895 Protéine
  • COCA1 Protéine
  • Dmel\CG7895 Protéine
  • DmNK-4 Protéine
  • DROHOXHK4 Protéine
  • DROHOXNK4 Protéine
  • FCC1 Protéine
  • HNPCC Protéine
  • HNPCC1 Protéine
  • HOX Protéine
  • LCFS2 Protéine
  • msh-2 Protéine
  • msh2 Protéine
  • MUTS homolog 2 Protéine
  • NK-4 Protéine
  • NK-4/msh-2 Protéine
  • NK4 Protéine
  • NK4/msh-2 Protéine
  • NKX2.5 Protéine
  • Tin Protéine
  • tin/NK4 Protéine
  • wu:fc06b02 Protéine
  • wu:fc13e09 Protéine
  • zgc:55333 Protéine

Protein level used designations for MSH2

mismatch repair protein , DNA mismatch repair protein Msh2 , mutS protein homolog 2 , mismatch repair protein Msh2 , hMSH2 , mutS-like protein 2 , MutS-like protein 2 , CG7895-PA , muscle-specific-homeodomain-2 , tin-PA

GENE ID SPECIES
100268052 Vitis vinifera
821383 Arabidopsis thaliana
17685 Mus musculus
81709 Rattus norvegicus
406845 Danio rerio
4436 Homo sapiens
378799 Gallus gallus
494002 Canis lupus familiaris
100337661 Sus scrofa
533115 Bos taurus
42536 Drosophila melanogaster
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