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Aperçu des produits pour CLOCK (CLOCK) Kits ELISA

Full name:
Clock Homolog (Mouse) Kits ELISA (CLOCK)
Chez www.anticorps-enligne.fr sont 7 Clock Homolog (Mouse) (CLOCK) Kits ELISA de 5 de différents fournisseurs disponibles. De plus, nous expédions CLOCK Anticorps (117) et CLOCK Protéines (5) et beaucoup plus de produits pour cette protéine. Un total de 137 CLOCK produits sont actuellement listés.
Synonymes:
5330400M04Rik, bHLHe8, bHLHe10, CG7391, clk, clock, dClck, dclk, dCLK/JRK, dClock, Dmel\\CG7391, Jerk, jrk, KAT13D, mKIAA0334, PAS1, Xclk, XClock, zCLOCK1, zfCLOCK1

CLOCK (CLOCK) Kits ELISA par réactivité

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Plus Kits ELISA pour CLOCK partenaires d'interaction

Fruit Fly (Drosophila melanogaster) Clock Homolog (Mouse) (CLOCK) interaction partners

  1. these results demonstrate a key role of Clk post-transcriptional control in stabilizing circadian transcription.

  2. Our findings suggest a novel role for clock protein (Montrer ARNTL Kits ELISA) phosphorylation in governing the relative strengths of entraining modalities by adjusting the dynamics of circadian gene expression.

  3. These results demonstrate that CLK phosphorylation influences the circadian period by regulating CLK activity and progression through the feedback loop.

  4. Computational dissection of CLK/CYC (Montrer COX6C Kits ELISA) context-specific binding sites reveals sequence motifs for putative partner factors, which are predictive for individual binding sites

  5. usp8 (Montrer USP8 Kits ELISA) loss of function (RNAi) or expression of a dominant-negative form of the protein (USP8 (Montrer USP8 Kits ELISA)-DN) enhances CLK/CYC (Montrer COX6C Kits ELISA) transcriptional activity and alters fly locomotor activity rhythms

  6. CLK has specific targets in different tissues, implying that important CLK partner proteins and/or mechanisms contribute to gene-specific and tissue-specific regulation

  7. CTRIP destabilizes CLK protein in a PER-independent manner and helps degradation of phosphorylated PER and TIM in the morning

  8. dPER(DeltaCBD) does not provoke the daily hyperphosphorylation of dCLOCK, indicating that direct interactions between dPER and dCLOCK are necessary for the dCLOCK phosphorylation

  9. findings show that Clk and cyc (Montrer COX6C Kits ELISA) act during starvation to modulate the conflict of whether flies sleep or search for food

  10. Here we examined the consequences of loss of clock function on reproductive fitness in Drosophila melanogaster with mutated period (per(0)), timeless (tim(0)), cycle (cyc (Montrer COX6C Kits ELISA)(0)), and Clock (Clk(Jrk)) genes

Zebrafish Clock Homolog (Mouse) (CLOCK) interaction partners

  1. effect of CRY (Montrer CRY2 Kits ELISA) in repressing transcription mediated by CLOCK-BMAL heterodimer

Mouse (Murine) Clock Homolog (Mouse) (CLOCK) interaction partners

  1. PI3K signaling plays a modulatory role in the regulation of the transcriptional rhythm of the Dbp (Montrer GC Kits ELISA) gene by targeting BMAL1 (Montrer ARNTL Kits ELISA) and CLOCK.

  2. Both clock- and feeding-dependent mechanisms regulate the daily accumulation of key enzymes in polyamine biosynthesis through rhythmic binding of BMAL1 (Montrer ARNTL Kits ELISA):CLOCK to conserved DNA elements

  3. RNA interference screens reveal the heterodimeric, circadian rhythm Transcription factors Clock and Bmal1 (Montrer ARNTL Kits ELISA) as genes required for the growth of acute myeloid leukemia (Montrer BCL11A Kits ELISA) cells in vitro and in vivo.

  4. Findings indicate that CLOCK protein (Montrer ARNTL Kits ELISA) plays an important role in fertility and its knockdown leads to reduction in reproduction and increased miscarriage risk.

  5. Irp2 (Montrer IREB2 Kits ELISA) mRNA transcription is promoted by circadian clock genes, including BMAL1 (Montrer ARNTL Kits ELISA), and the CLOCK heterodimer.

  6. In CLOCK-deficient fibroblasts, knockdown of Npas2 (Montrer NPAS2 Kits ELISA) leads to arrhythmicity, suggesting that NPAS2 (Montrer NPAS2 Kits ELISA) can compensate for loss of CLOCK in peripheral cells as well as in suprachiasmatic nucleus.

  7. SERPINA3K is involved in the Clock gene-mediated male fertility by regulating acrosin (Montrer ACR Kits ELISA) activity and provide the first evidence that SERPINA3K could be regulated by Clock gene via retinoic acid-related orphan receptor (Montrer NR1D2 Kits ELISA) response elements.

  8. Circadian CLOCK Mediates Activation of Transforming Growth Factor-beta Signaling and Renal Fibrosis through Cyclooxygenase 2 (Montrer PTGS2 Kits ELISA).

  9. Propose that USF1 (Montrer USF1 Kits ELISA) is an important modulator of molecular and behavioral circadian rhythms in mammals via DNA-binding of the CLOCK:BMAL1 complex.

  10. Clock is a novel regulator of psoriasis-like skin inflammation in mice via direct modulation of IL-23R (Montrer IL23R Kits ELISA) expression in gamma/delta+ T cells

Human Clock Homolog (Mouse) (CLOCK) interaction partners

  1. Clock circadian regulator (CLOCK) gene single nucleotide polymorphism rs1801260 minor allele C showed a significantly higher association with the prevalence of diabetes in the Japanese population independent of body mass index (BMI).

  2. Immunostaining of CLOCK and PER2 (Montrer PER2 Kits ELISA) protein was detected in the granulosa cells of dominant antral follicles but was absent in the primordial, primary, or preantral follicles of human ovaries.Oscillating expression of the circadian gene PER2 (Montrer PER2 Kits ELISA) can be induced by testosterone in human granulosa cells in vitro. Expression of STAR also displayed an oscillating pattern after testosterone stimulation

  3. possible circadian rhythm in full-term placental expression

  4. Findings indicate that CLOCK protein (Montrer ARNTL Kits ELISA) plays an important role in fertility and its knockdown leads to reduction in reproduction and increased miscarriage risk.

  5. Upregulation of CLOCK is associated with the expression of HIF-1alpha and VEGF in varicose veins.

  6. when overexpressed, c-MYC (Montrer MYC Kits ELISA) is able to repress Per1 (Montrer PER1 Kits ELISA) transactivation by BMAL1 (Montrer ARNTL Kits ELISA)/CLOCK via targeting selective E-box sequences. Importantly, upon serum stimulation, MYC (Montrer MYC Kits ELISA) was detected in BMAL1 (Montrer ARNTL Kits ELISA) protein complexes

  7. CLOCK, ARNTL (Montrer ARNTL Kits ELISA), and NPAS2 (Montrer NPAS2 Kits ELISA) gene polymorphisms may have a role in seasonal variations in mood and behavior

  8. minor polymorphisms of CLOCK may be associated with poor morning gastric motility, and may have a combinatorial effect with PER3.

  9. these findings suggest that sumoylation plays a critical role in the spatiotemporal co-activation of CLOCK-BMAL1 (Montrer ARNTL Kits ELISA) by CBP (Montrer CREBBP Kits ELISA) for immediate-early (Montrer JUN Kits ELISA) Per induction and the resetting of the circadian clock.

  10. the circadian gene hClock promoted CRC (Montrer CALR Kits ELISA) progression and inhibit tumor cell apoptosis in vitro and in vivo, while silencing hClock was able to reverse this effect.

Xenopus laevis Clock Homolog (Mouse) (CLOCK) interaction partners

  1. the second half of the photolyase homology region (PHR) of CRY (Montrer CRY2 Kits ELISA) is important for repression through facilitating interaction with CLOCK

CLOCK profil antigène

Antigen Summary

This gene product regulates circadian rhythm and metabolism. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and a DNA binding histone acetyltransferase. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with CLOCK

  • Clock (Clk) Elisa Kit
  • clock homolog (mouse) (CLOCK) Elisa Kit
  • clock circadian regulator (clock) Elisa Kit
  • clock homolog (CLOCK) Elisa Kit
  • clock (clock) Elisa Kit
  • circadian locomotor output cycles kaput (Clock) Elisa Kit
  • clock circadian regulator (Clock) Elisa Kit
  • clock circadian regulator (CLOCK) Elisa Kit
  • 5330400M04Rik Elisa Kit
  • bHLHe8 Elisa Kit
  • bHLHe10 Elisa Kit
  • CG7391 Elisa Kit
  • clk Elisa Kit
  • clock Elisa Kit
  • dClck Elisa Kit
  • dclk Elisa Kit
  • dCLK/JRK Elisa Kit
  • dClock Elisa Kit
  • Dmel\\CG7391 Elisa Kit
  • Jerk Elisa Kit
  • jrk Elisa Kit
  • KAT13D Elisa Kit
  • mKIAA0334 Elisa Kit
  • PAS1 Elisa Kit
  • Xclk Elisa Kit
  • XClock Elisa Kit
  • zCLOCK1 Elisa Kit
  • zfCLOCK1 Elisa Kit

Protein level used designations for CLOCK

CG7391-PA , CG7391-PD , CG7391-PF , CG7391-PG , CG7391-PH , CLOCK , Clk-PA , Clk-PD , Clk-PF , Clk-PG , Clk-PH , clock , dClock , clock homolog (mouse) , clock homolog , circadian locomoter output cycles protein kaput , circadian locomoter output cycles protein kaput-like , Clock1a , clk1 , circadian locomoter output cycles kaput , mCLOCK , rCLOCK , circadian locomoter output cycles kaput protein , class E basic helix-loop-helix protein 8 , circadian rhythmicity protein CLOCK

GENE ID SPECIES
38872 Drosophila melanogaster
461312 Pan troglodytes
475145 Canis lupus familiaris
786637 Bos taurus
100008576 Meleagris gallopavo
100017022 Monodelphis domestica
100034166 Equus caballus
100038163 Xenopus (Silurana) tropicalis
100171391 Ovis aries
100172630 Pongo abelii
100349684 Oryctolagus cuniculus
100407407 Callithrix jacchus
30140 Danio rerio
100606130 Nomascus leucogenys
100628097 Sus scrofa
12753 Mus musculus
60447 Rattus norvegicus
9575 Homo sapiens
399157 Xenopus laevis
373991 Gallus gallus
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