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A hierarchic gene expression of copper homeostatic genes was demonstrated between atp7a (Montrer ATP7A Kits ELISA), sp1 and sod1 (Montrer SOD1 Kits ELISA) in zebrafish.
zebrafish Sp1-like protein is structurally and functionally comparable to human Sp1
these findings demonstrate that p53 (Montrer TP53 Kits ELISA) can repress MCAK (Montrer KIF2C Kits ELISA) promoter activity indirectly via down-regulation of Sp1 (Montrer PSG1 Kits ELISA) expression level, and suggest that MCAK (Montrer KIF2C Kits ELISA) elevation in human tumor cells might be due to p53 (Montrer TP53 Kits ELISA) mutation
Our study provides new evidence that interaction of KLF6 and Sp1 regulates basigin-2 expression in hepatocellular carcinoma
Our study showed there was a positive correlation between Sp1 (Montrer PSG1 Kits ELISA) and COX2 (Montrer COX2 Kits ELISA) expression in pancreatic ductal adenocarcinoma
Data indicate the Sp1 (Montrer PSG1 Kits ELISA) oncogene (Montrer RAB1A Kits ELISA) functions as a positive regulator for BCR/ABL (Montrer ABL1 Kits ELISA) expression.
This result indicates that the formation of copper-finger protein of Sp1 (Montrer PSG1 Kits ELISA) is the molecular basis of copper sensing for the transcriptional regulation of hCtr1 (Montrer SLC31A1 Kits ELISA) in mammalian cells.
Data show that SOX9 (Montrer SOX9 Kits ELISA) regulates CEACAM1 (Montrer CEACAM1 Kits ELISA) primarily via Sp1 (Montrer PSG1 Kits ELISA) and ETS1 (Montrer ETS1 Kits ELISA).
Sp1 (Montrer PSG1 Kits ELISA), Sp3 (Montrer SP3 Kits ELISA) and Sp4 are non-oncogene (Montrer RAB1A Kits ELISA) addiction (NOA (Montrer DLAT Kits ELISA)) genes and are attractive drug targets for individual and combined cancer chemotherapies.
lnc AGAP2 (Montrer AGAP2 Kits ELISA)-AS1 (Montrer PTGDR Kits ELISA) upregulated by SP1 (Montrer PSG1 Kits ELISA) plays an important role in gastric cancer development and progression by suppressing P21 (Montrer CDKN1A Kits ELISA) and E-cadherin (Montrer CDH1 Kits ELISA)
High SP1 (Montrer PSG1 Kits ELISA) expression is associated with obesity.
The up-regulation of Hsp27 (Montrer HSPB1 Kits ELISA) by E2 is mediated by ERalpha (Montrer ESR1 Kits ELISA)/Sp1 (Montrer PSG1 Kits ELISA).
study demonstrates the co-expression of DLX3 (Montrer DLX3 Kits ELISA), PPARG (Montrer PPARG Kits ELISA) and SP1 in trophoblast binucleated cell (BNC)nuclei; this suggests a possible role of these transcription factors through BNC specific genes at the time of pre-placental differentiation
likely involvement of the Sp family in regulating PTH (Montrer PTH Kits ELISA) gene expression through interactions with an Sp1 DNA element in the hormone's promoter.
These results demonstrate that the single nucleotide polymorphism alters the bovine FASN (Montrer FASN Kits ELISA) promoter activity in vitro and the Sp1/Sp3 binding ability of the sequence.
The coordinate regulation of the bovine PRNP (Montrer PRNP Kits ELISA) promoter suggests the two Sp1 binding site polymorphisms control Sp1 binding to the PRNP (Montrer PRNP Kits ELISA) promoter and its activity.
The Genomic Context and Corecruitment of SP1 Affect ERRalpha (Montrer ESRRA Kits ELISA) Coactivation by PGC-1alpha (Montrer PPARGC1A Kits ELISA) in Muscle Cells
These results suggest that Sp1 regulates gene expression of AACS (Montrer AACS Kits ELISA) in Neuro-2a cells and ketone body utilization affects the balance of histone acetylation.
the results obtained in this study show that Znf179 (Montrer RNF112 Kits ELISA) autoregulation through Sp1-dependent mechanism plays an important role in neuroprotection, and NGF (Montrer NGFB Kits ELISA)-induced Sp1 signaling may help attenuate more extensive (ROS (Montrer ROS1 Kits ELISA)-induced) damage following brain injury
Using MA, we demonstrated Sp1 as a critical stemness-related transcriptional factor protecting GBM cells against stress- and TMZ-induced death. Thus, Sp1 inhibition may prevent recurrence of malignant cells persisting after primary therapy.
Results suggest that 25-hydroxycholesterol (25-HC) induced the interaction between NFATc1 (Montrer NFATC1 Kits ELISA) and Sp1, reducing the level of free Sp1 to inhibit microRNA miR (Montrer MLXIP Kits ELISA)-139-5p expression and promote osteoclastogenesis.
data indicated that (-)-Epicatechin inhibited AngII-induced cardiac hypertrophy by activating the SP1/SIRT1 (Montrer SIRT1 Kits ELISA) signaling pathway.
This resulted in Sp1 displacement from the promoter and binding of Sp3 (Montrer SP3 Kits ELISA) to it, leading to p300 (Montrer NOTCH1 Kits ELISA) recruitment and histone acetylation, activating transcription. This is the first study addressing the mechanisms of physiological TLR5 (Montrer TLR5 Kits ELISA) expression in the intestine. Additionally, a novel insight is gained into Sp1/Sp3 (Montrer SP3 Kits ELISA)-mediated gene regulation that may apply to other genes
adrenergic stimulation induced complex formation between Ifrd1 (Montrer IFRD1 Kits ELISA), Sp1 and mSIN3B, which is a component of the SIN complex containing histone deacetylase (Montrer HDAC1 Kits ELISA), in brown adipocytes. These findings, therefore, suggest that Ifrd1 (Montrer IFRD1 Kits ELISA) could be a pivotal negative regulator of sympathetic regulation of thermogenic and mitochondrial gene expression in brown adipocytes by interacting with Sp1 and the mSIN3 complex.
Dp71 (Montrer DMD Kits ELISA) expression in hepatic cells is carried out, in part, by YY1 (Montrer YY1 Kits ELISA)-, Sp1- and Sp3 (Montrer SP3 Kits ELISA)-mediated transcription from the Dp71 (Montrer DMD Kits ELISA) promoter.
SP1 expression was up-regulated in the tubular epithelial cells after acute kidney injury induced by ischemia-reperfusion.MiR-204 regulates epithelial-mesenchymal transition by targeting SP1 in the tubular epithelial cells.
The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene.
, transcription factor Sp1
, transcription factor
, Sp1 transcription factor
, transcription factor Sp1-like
, specificity protein 1
, specific protein-1
, trans-acting transcription factor 1