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anti-Rat (Rattus) MAP3K3 Anticorps:
anti-Human MAP3K3 Anticorps:
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Dog (Canine) Monoclonal MAP3K3 Primary Antibody pour IF, WB - ABIN968365
Ellinger-Ziegelbauer, Brown, Kelly, Siebenlist et al.: Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 ... dans The Journal of biological chemistry 1997
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Dog (Canine) Monoclonal MAP3K3 Primary Antibody pour IF, WB - ABIN968366
Yang, Lai, Lai, Hsu, Kuo, Yu, Lin, Yang, Kuo, Wu, Chung: Phenethyl isothiocyanate inhibits migration and invasion of human gastric cancer AGS cells through suppressing MAPK and NF-kappaB signal pathways. dans Anticancer research 2010
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All these suggest that the MAP3K M1P site is a potential interacting partner of MAP3K SH3 domain (Montrer ITSN1 Anticorps), which may mediate the intermolecular recognition between hPTTG1 and MAP3K.
Polymorphisms in MAP3K3, MMP24 (Montrer MMP24 Anticorps) and IGF1R (Montrer IGF1R Anticorps) are associated with greater height and act additively on height in children of an admixed population.
MAP3K3 overexpression is an independent poor prognostic indicator in ovarian carcinoma.
MAP3K3 may potentially not only serve as diagnostic/prognostic markers for patients with lung cancer but also provide an indicator for future investigations into immunomodulatory therapies for lung cancer.
studies identify gain of MEKK3 signallin (Montrer KLF2 Anticorps)g and KL (Montrer KLF4 Anticorps)F2/4 function as causal mechanisms for cerebral cavernous malformations pathogenesis that may be targeted to develop new CCM therapeutics
High MEKK3 expression is associated with renal clear cell carcinoma.
MEKK3 expression was significantly higher in patients with renal clear cell carcinoma than in controls.
This (Montrer NBR1 Anticorps) study identified an NBR1-MEKK3 complex as a key regulator of JNK s (Montrer NBR1 Anticorps)ignaling and adipose tissue inflam (Montrer MAPK8 Anticorps)mation in obesity.
Our finding that Verrucous venous malformation contains a MAP3K3 mutation supports our impression that this lesion is a venous anomaly.
MEKK3 expression was positively correlated with survivin (Montrer BIRC5 Anticorps).
MiR (Montrer MLXIP Anticorps)-188 regulated MAP3K3 expression in bone marrow cells.MAP3K3 is involved in miR (Montrer MLXIP Anticorps)-188-induced promotion of bone marrow cells senescence.
this study shows that TAK1 (Montrer NR2C2 Anticorps) negatively regulates lipopolysaccharide-induced cytokine secretion in myeloid cells by inhibiting MEKK3 activities
endothelial-specific loss of Mekk3, Klf2 (Montrer KLF2 Anticorps) or Klf4 (Montrer KLF4 Anticorps) markedly prevents cerebral cavernous malformation lesion formation, reverses the increase in Rho activity, and rescues lethality
CCM2 (Montrer CCM2 Anticorps):MEKK3-mediated regulation of Rho-ROCK signalling is required for maintenance of neurovascular integrity, a mechanism by which CCM2 (Montrer CCM2 Anticorps) loss leads to disease.
NBR1 (Montrer NBR1 Anticorps) is increased in adipose tissue macrophages in obese mice. The NBR1 (Montrer NBR1 Anticorps)-MEKK3 complex is important in JNK (Montrer MAPK8 Anticorps) activation in macrophages.
MEKK2 (Montrer MAP3K2 Anticorps) alone can suppress T-cell TGF-beta (Montrer TGFB1 Anticorps) responses. MEKK2 (Montrer MAP3K2 Anticorps) or MEKK3 can cause ERK1/2 (Montrer MAPK1/3 Anticorps) to phosphorylate SMAD2 (Montrer SMAD2 Anticorps)/3 and suppress R-SMAD (Montrer SMAD1 Anticorps)-dependent transcription. MEKK2 (Montrer MAP3K2 Anticorps) and MEKK3 play overlapping roles in regulating Th-cell differentiation via TGF-beta (Montrer TGFB1 Anticorps)
Using Mekk3-deficient murine T cells, the authors concluded MEKK3 expression is required for mounting optimal T cell responses in vivo and is involved in mediating the TCR-dependent Rac1/2 signals for IFN-gamma (Montrer IFNG Anticorps) production through the MAPK (Montrer MAPK1 Anticorps) pathways.
The signaling defect of elevated interleukin (IL)-12 (Montrer IL12A Anticorps) overproducing cells in nonobese diabetic mice could be attributed to, at least partially, the overexpression of a single MAP3K, namely MEKK3.
Strikingly, chimeric mice transplanted with Mekk3(Deltaflox/-) BM exhibited a reduction in tumor growth and vessel density compared with mice transplanted with Mekk3(Deltaflox/+) BM cells.
PB1 (Montrer GPR97 Anticorps) domain mediates the association of MEKK2 (Montrer MAP3K2 Anticorps) and MEKK3 with MEK5 (Montrer MAP2K5 Anticorps) and that the respective PB1 (Montrer GPR97 Anticorps) domains of these kinases are critical for regulation of the ERK5 (Montrer MAPK7 Anticorps) pathway.
This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively\; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
mitogen-activated protein kinase kinase kinase 3
, MAP/ERK kinase kinase 3
, MAPK/ERK kinase kinase 3
, MEK kinase 3
, MEKK 3
, mitogen activated protein kinase kinase kinase 3