MAP3K3 Produits
(Mitogen-Activated Protein Kinase Kinase Kinase 3 (MAP3K3))
Catégories
This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively\; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
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Catégories MAP3K3 en vedette
MAP3K3 Anticorps
High quality antibodies with extensive validation data.
MAP3K3 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
MAP3K3 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IHC
Validations
- (4)
N° du produit
ABIN7268652
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
IHC
Validations
- (3)
N° du produit
ABIN7258882
Quantité
200 μL
Fiche technique
Fiche technique
Reactivity
Mouse, Rat
Application
WB, IHC (p)
Validations
- (4)
N° du produit
ABIN3044008
Quantité
100 μg
Fiche technique
Fiche technique
MAP3K3 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Insect cells (Sf21)
Validations
- (2)
N° du produit
ABIN5570599
Quantité
5 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1310214
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1310216
Quantité
10 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits MAP3K3
: "Phenethyl isothiocyanate inhibits migration and invasion of human gastric cancer AGS cells through suppressing MAPK and NF-kappaB signal pathways." dans: Anticancer research, Vol. 30, Issue 6, pp. 2135-43, (2010) (PubMed).: "PB1 domains of MEKK2 and MEKK3 interact with the MEK5 PB1 domain for activation of the ERK5 pathway." dans: The Journal of biological chemistry, Vol. 278, Issue 39, pp. 36989-92, (2003) (PubMed).
: "Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3." dans: Nature immunology, Vol. 5, Issue 1, pp. 98-103, (2003) (PubMed).
: "Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock." dans: Nature cell biology, Vol. 5, Issue 12, pp. 1104-10, (2003) (PubMed).
: "Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 ..." dans: The Journal of biological chemistry, Vol. 272, Issue 5, pp. 2668-74, (1997) (PubMed).
Synonymes et noms alternatifs relatifs à MAP3K3
mitogen activated protein kinase kinase kinase 3 (Map3k3), mitogen-activated protein kinase kinase kinase 3 (MAP3K3), mitogen-activated protein kinase kinase kinase 3 (Map3k3), mitogen-activated protein kinase kinase kinase 3 (map3k3), AW548911, MAPKKK3, MEKK3, Mekk3, mKIAA4031Protein level used designations for MAP3K3
- mitogen-activated protein kinase kinase kinase 3
- MAP/ERK kinase kinase 3
- MAPK/ERK kinase kinase 3
- MEK kinase 3
- MEKK 3
- mitogen activated protein kinase kinase kinase 3
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