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AKAP7 encodes a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific subcellular compartments. De plus, nous expédions AKAP7 Protéines (9) et et beaucoup plus de produits pour cette protéine.
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Malonate in the nucleotide-binding site traps human AKAP18-gamma in a novel conformational state.
PKC tethered to AKAP7alpha was less susceptible to inhibition from the ATP-competitive inhibitor Go6976 and the substrate-competitive inhibitor PKC 20-28, but not the activation-competitive inhibitor calphostin C.
Data from studies using recombinant proteins suggest that both AKAP7-gamma and AKAP7-alpha exhibit high-affinity interactions with isoenzymes of PKC (protein kinase C (Montrer PKC Anticorps)); AKAP7 could dictate PKC (Montrer PRRT2 Anticorps) localization/function.
AKAP7gamma is the first nuclear AKAP (Montrer AKAP1 Anticorps) to bind RI and may be responsible for positioning PKA via RI and/or RII to regulate PKA-mediated gene transcription in both somatic cells and oocytes
AKAP15 regulates ENaC (Montrer SCNN1A Anticorps) via a novel PKA-independent pathway
AKAP18 contains a phosphodiesterase domain that binds AMP (Montrer APRT Anticorps).
Genetic ablation of AKAP7 specifically from dentate granule cells results in disruption of mossy fiber-CA3 (Montrer CA3 Anticorps) pyramidal neuron long-term potentiation directly initiated by cAMP, and the AKAP7 mutant mice are selectively deficient in pattern separation behaviors. The results suggest that the AKAP7/PKA complex in the mossy fiber projections plays an essential role in synaptic plasticity and contextual memory formation.
AKAP7 is not required for regulation of Ca(2 (Montrer CA2 Anticorps)+) handling in mouse cardiomyocytes.
AKAP15 co-immunoprecipitates with CaV1.2 (Montrer CACNA1C Anticorps) and CaV1.3 (Montrer CACNA1D Anticorps) channels. AKAP15 has overlapping localization with CaV1.2 (Montrer CACNA1C Anticorps) and CaV1.3 (Montrer CACNA1D Anticorps) channels in cell bodies and proximal dendrites and is closely co-localized with CaV1.2 (Montrer CACNA1C Anticorps) channels in punctate clusters.
CaV1.2 (Montrer CACNA1C Anticorps) channels in DCT (Montrer DCT Anticorps)-/- myocytes fail to respond to activation of adenylyl cyclase by forskolin, and the localized expression of AKAP15 is reduced
This gene encodes a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific subcellular compartments. AKAPs have a common RII-binding domain, but contain different targeting motifs responsible for directing PKA to distinct intracellular locations. Three alternatively spliced transcript variants encoding different isoforms have been described.
A kinase (PRKA) anchor protein 7
, a-kinase anchor protein 7 isoform gamma-like
, A-kinase anchor protein 18 kDa
, A-kinase anchor protein 7 isoform gamma
, A-kinase anchor protein 7 isoforms alpha and beta
, A-kinase anchor protein 9 kDa
, AKAP 18
, AKAP-7 isoform gamma
, AKAP-7 isoforms alpha and beta
, PRKA7 isoform gamma
, PRKA7 isoforms alpha/beta
, A-kinase anchor protein 7
, A-kinase anchor protein 18
, AKAP 9
, AKAP-7 isoform alpha
, PRKA7 isoform alpha
, protein kinase A anchoring protein 7
, protein kinase A-anchoring protein 7 isoform alpha
, protein kinase A-anchoring protein 7 isoform gamma
, A-kinase anchor protein 7 isoforms delta and gamma
, A-kinase anchoring protein 18 ,isoform delta
, AKAP-7 isoforms delta and gamma
, PRKA7 isoforms delta and gamma
, protein kinase A-anchoring protein 7 isoforms delta and gamma