Adrenergic Receptor, alpha 1d Protéines (ADRA1D)

Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. De plus, nous expédions Adrenergic Receptor, alpha 1d Anticorps (35) et Adrenergic Receptor, alpha 1d Kits (7) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
ADRA1D 11550  
Rat ADRA1D ADRA1D 29413 P23944
ADRA1D 146 P25100
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Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Souris rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Connectez-vous pour afficher 50 to 55 Days
$5,262.31
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Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
$6,749.58
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ADRA1D Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Mouse (Murine)
,
Human
,

Plus protéines pour Adrenergic Receptor, alpha 1d (ADRA1D) partenaires d'interaction

Mouse (Murine) Adrenergic Receptor, alpha 1d (ADRA1D) interaction partners

  1. Our results suggest that stimulation of alpha1-ARs results in a favorable metabolic profile of increased glucose tolerance, cardiac glucose uptake, leptin secretion and increased whole body lipid metabolism that may contribute to its previously recognized cardioprotective and neuroprotective benefits.

  2. Erythropoietin seems to reverse sepsis-induced vasoplegia to NE through the preservation of alpha1D adrenoceptor mRNA/protein expression, inhibition of GRK2-mediated desensitization, and attenuation of NO overproduction in the mouse aorta.

  3. The alpha1-AR may play an important role in the development of atrial fibrillation.

  4. the alpha(1A)-AR subtype mediates adrenergic vasoconstriction in murine ophthalmic arteries.

  5. investigate the mechanisms involved in the compartmentalization of the PKA-dependent modulation of I(to) in response to alpha1-AR activation.

  6. in mouse ureters: the mRNA for the alpha1A-adrenoceptor was more prevalent than those for the alpha1B- and alpha1D-adrenoceptors

  7. Data indicate that alpha1D- and alpha2C-adrenoceptors interact to enhance adrenergic reactivity (norepinephrine-induced constriction) of mesenteric veins but not in mesenteric arteries.

  8. Use fluorescent ligand binding to examine Adra1d distribution in arteries.

  9. The right ventricle inotropic response to alpha(1)-adrenergic receptors is switched from negative to positive in heart failure, through a pathway involving increased myofilament Ca(2+) sensitivity.

  10. the a1D-adrenoceptor location in native smooth-muscle cells is not influenced by other a1-adrenoceptors; a1-subtypes do not interact but provide independent alternative signals for vascular regulation

  11. The results indicate that the alpha(1D)-AR participates directly in sympathetic regulation of systemic blood pressure by vasoconstriction.

  12. Adrenergic receptors alpha(1d): Data suggest that alpha1D-AR plays an important role in developing a high BP in response to dietary salt-loading, and that selective alpha1D-AR antagonists could have therapeutic potential in the treatment of hypertension.

  13. mouse hearts lacking alpha(1A)- and alpha(1B)-adrenergic receptors retain functional alpha(1)-adrenergic receptor responses involving decreases of coronary flow and ventricular pressure that reflect alpha(1D)-adrenergic receptor-mediated vasoconstriction

  14. Alpha 1d adrenoceptors are functionally important in mediating a variety of stimulus-induced changes in locomotor behaviors. Some post-synaptic responses to environmental stimuli are mediated by alpha 1d adrenergic receptors.

  15. the alpha1d-AR receptor plays an important role in the process of auditory sensory function, attention or working memory rather than reference memory.

  16. Deletion of the functional alpha1D leads to an antihypertensive effect.

  17. alpha1D-adrenergic receptors are regulated by syntrophins through a PDZ domain-mediated interaction

  18. Couplings of 5-HT2B and adrenergic alpha1D autoreceptors to reactive oxygen species and TNF-alpha signaling control neurotransmitter metabolism in 1C11-derived neuronal cells.

  19. These results demonstrate that alpha(1)-adrenoceptors, particularly alpha(1A)-adrenoceptors, are required for normal contractility of the vas deferens and consequent sperm ejaculation as well as having a function in fertility

  20. Norepinephrine acts through both alpha1- and beta-adrenergic receptors located on the soma/dendrites of GnRH neurons to directly suppress their excitability throughout the estrous cycle and after ovariectomy.

Human Adrenergic Receptor, alpha 1d (ADRA1D) interaction partners

  1. Hetero-oligomerization of a1B/D-adrenergic receptor with the chemokine (C-X-C motif) receptor 4:atypical chemokine receptor 3 heteromeric complex is required for a1B/Dadrenergic receptor function.

  2. processing of the ADRA1D NT domain is a physiological mechanism employed by cells to generate a functional ADRA1D isoform with optimal pharmacodynamic properties.

  3. expression of carboxyl terminus-truncated alpha1D-adrenoceptors alters ERK and p38 phosphorylation state.

  4. Immunoreactivity for ADRA2D was densely distributed in submucosal glands of nasal turbinates.

  5. In conclusion, our work clarified some cellular aspects promoted by alpha1D-AR activity modulation and supports a further pharmacological approach in the cure of hormone-refractory PC, by targeting specifically this AR subtype

  6. This study showed that ADRA1D gene involved in neuronal growth and cerebellum development and associated with neurological and psychological disorders.

  7. alpha1A-adrenergic receptors are stably expressed and stimulate cell migration and TGF-beta1, IGF-1, hyaluronan and PIP production in human skin fibroblasts.

  8. Cross-talk between alpha1D-adrenoceptors and transient receptor potential vanilloid type 1 triggers prostate cancer cell proliferation.

  9. Mean alpha-receptor stain rates in renal pelvis were 2.65 +/- 0.74, 1.35 +/- 0.81 and 2.9 +/- 0.30 for alpha 1A, 1B and 1D, respectively. For calyces, the rates are 2.40 +/- 0.82, 1.50 +/- 0.76 and 2.75 +/- 0.44 for alpha 1A, 1B and 1D, respectively.

  10. alpha(1)(D)-adrenoceptors in the lower urinary tract might play an important role in the pathophysiology of lower urinary tract disorders. [review]

  11. Data show that alpha-dystrobrevin-1 recruits alpha-catulin, which supersensitizes alpha(1D)-AR functional responses by recruiting effector molecules to the signalosome.

  12. Genetic characteristics associated with response to domperidone therapy included polymorphisms in the drug transporter gene ABCB1, the potassium channel KCNH2 gene, and alpha1D--adrenoceptor ADRA1D gene.

  13. Data show thah activation of alpha(1)A- or alpha(1)B-adrenergic receptors inhibits serum-promoted cell proliferation, whereas alpha(1)D-AR activation does not show such an inhibitory effect.

  14. These studies suggest that gC1qR interacts specifically with alpha1B- and alpha1D-, but not alpha1A-ARs, and this interaction depends on the presence of an intact C-tail.

  15. cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors

  16. alpha(1A)- and alpha(1D)-adrenergic receptors mediate G(1)-S cell-cycle arrest

  17. Human ureter was endowed with each alpha1 AR subtype, although alpha1D and alpha1A ARs were prevalent over alpha1B ARs.

  18. alpha1D-adrenergic receptors are regulated by syntrophins through a PDZ domain-mediated interaction

  19. Differential methylation of proximal GC boxes in the ADRA1D promoter disrupts Sp1 binding in a cell-specific manner resulting in repression of basal alpha1dAR expression.

  20. ADRA1D polymorphisms are predictive markers of the response to beta-blockers

Profil protéine Adrenergic Receptor, alpha 1d (ADRA1D)

Profil protéine

Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region.

Gene names and symbols associated with ADRA1D

  • adrenergic receptor, alpha 1d (Adra1d)
  • adrenoceptor alpha 1D (Adra1d)
  • adrenoceptor alpha 1D (ADRA1D)
  • Adra-1 Protéine
  • ADRA1 Protéine
  • ADRA1A Protéine
  • ADRA1R Protéine
  • Adrd1 Protéine
  • ALPHA1 Protéine
  • alpha1D-AR Protéine
  • DAR Protéine
  • dJ779E11.2 Protéine
  • Gpcr8 Protéine
  • Spr8 Protéine
  • [a]1d Protéine

Protein level used designations for ADRA1D

alpha-1A adrenergic receptor , alpha-1D adrenergic receptor , alpha-1D adrenoceptor , alpha-1D adrenoreceptor , RA42 , adrenergic receptor delta1 , adrenergic receptor, alpha 1d , adrenergic, alpha-1D-, receptor , alpha 1D-adrenoceptor , alpha 1D-adrenoreceptor , adrenergic, alpha -1D-, receptor , adrenergic, alpha-1A-, receptor , alpha-1D-adrenergic receptor , alpha-adrenergic receptor 1a , alpha 1d adrenoceptor

GENE ID SPECIES
11550 Mus musculus
29413 Rattus norvegicus
146 Homo sapiens
552898 Sus scrofa
100009398 Oryctolagus cuniculus
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