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Diurnal patterns of salivary alpha amylase and salivary IgA exist in healthy young children and are not affected by their nutrient intake, sex, Asian ethnicity, and body mass index.
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66 proteins that interact with amylase in whole saliva were identified.
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AMY1 copy number was significantly correlated with the variation observed in salivary amylase production and enzyme activity but did not explain the majority of observed variation between individuals. AMY1-odd and AMY1-even haplotypes showed a different relationship between copy number and expression levels, but the difference was not statistically significant.
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Alcohol dependent patients showed significantly lower stress-related salivary alpha-amylase activity than healthy controls.
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Results from 2 case-control cohorts of Chinese and Malays, show no previously reported association between AMY1 and obesity or body mass index.
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It was concluded that the genetic variant determining starch metabolism influences the response to weight-loss dietary intervention. Overweight and obese individuals carrying the AMY1-AMY2 rs11185098 genotype associated with higher amylase activity may have greater loss of adiposity during low-calorie diet interventions.
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higher levels of sAA in EHS participants
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Serum amylase levels in the normal range are positively associated with integrated islet beta cell function in patients with early type 2 diabetes.
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Our findings suggest an effect of the interaction between starch intake and AMY1 copy number on obesity. Individuals with high starch intake but low genetic capacity to digest starch had the lowest BMI, potentially because larger amounts of undigested starch are transported through the gastrointestinal tract, contributing to fewer calories extracted from ingested starch.
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Data show that carcinoembryonic antigen (CEA) modestly differentiated between mucinous and nonmucinous lesions, and amylase did not distinguish intraductal papillary mucinous neoplasms (IPMNs) from mucinous cystadenomas (MCAs).
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genetic association studies in a population of men in Republic of Korea: Data suggest that low AMY1A gene copy number is associated with high insulin resistance and thus with genetic predisposition to diabetes type 2 and metabolic syndrome.
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The purpose of this study was to a) determine the heart rate variability (HRV) and saliva markers of immunity (salivary immunoglobulin A; sIgA) and stress (salivary alpha-amylase; sAA) responses to chronic training in elite swimmers with a disability.
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Alpha-amylase in blood increases after pharmacological activation of the adrenergic pathways suggesting that sympathetic receptors are responsible for these changes. Psychological stress, however, does not seem to have an impact on alpha-amylase in blood
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low serum amylase level is significantly associated with increased risk of gestational diabetes mellitus
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Diurnal and stress-response salivary alpha amylase patterns were related to child adiposity: decreased morning alpha amylase was associated with increased BMI.
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Our current study suggests putative benefits of high number of AMY1 copies (and related production of salivary amylase) on energy metabolism in Mexican children.
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Splenic asthenia children had positive correlations between AMY1 copy number and sAA activity before or after citric acid stimulation.
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Results suggest that AMY1 copy number and salivary alpha-amylase (sAA) amount played crucial roles in sAA activity; however, the roles were attenuated after stimulation due to fortified release of glycosylated sAA
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Elevation in AMY1a following a second bout of downhill running may indicate an adaptive stress response which reduces the inflammatory events resulting from this type of exercise or an exercise-induced enhancement in innate secretory immunity.
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findings suggest that both affective arousal andvalence should be accounted for when examining differences in salivary alpha Amylase reactivity and diurnal patterns.
