anti-Ataxin 7 (ATXN7) Anticorps

The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord.

afficher tous les anticorps Gène GeneID UniProt
Anti-Humain ATXN7 ATXN7 6314 O15265
Anti-Souris ATXN7 ATXN7 246103 Q8R4I1
Anti-Rat ATXN7 ATXN7 361015  
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Top anti-ATXN7 Anticorps sur anticorps-enligne.fr

Showing 10 out of 57 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-ATXN7 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: ACHN cell lysate 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Boeuf (Vache) Lapin Inconjugué WB Host: Rabbit <br /> Target Name: Atxn7 <br /> Sample Tissue: Rat Small Intestine lysates <br /> Antibody Dilution: 1.0 µg/mL 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Humain Lapin Inconjugué WB Western blot analysis of Ataxin 7 expression in A549 (A), NIH3T3 (B), PC12 (C) whole cell lysates. 200 μL Connectez-vous pour afficher 13 to 14 Days
$487.50
Détails
Humain Souris Inconjugué ICC, IF, IHC, WB   100 μg Connectez-vous pour afficher 1 to 2 Days
$495.83
Détails
Humain Lapin Inconjugué WB 0.1 mL Connectez-vous pour afficher 7 to 9 Days
$556.31
Détails
Cobaye Lapin Inconjugué WB 50 μg Connectez-vous pour afficher 7 to 9 Days
$551.83
Détails
Humain Lapin Inconjugué WB ATXN7 Antibody (Center)  western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the ATXN7 antibody detected the ATXN7 protein (arrow). 400 μL Connectez-vous pour afficher 10 to 11 Days
$324.50
Détails
Humain Lapin Inconjugué WB Western blot analysis in CEM cell line lysates (35ug/lane). 400 μL Connectez-vous pour afficher 2 to 3 Days
$515.63
Détails
Humain Lapin Inconjugué ELISA, WB The Ataxin-7 Antibody is used in Western blot to detect Ataxin 7 in HeLa cell lysates. 0.1 mg Connectez-vous pour afficher 2 to 6 Days
$377.30
Détails
Humain Souris Inconjugué WB   100 μL Connectez-vous pour afficher 7 to 9 Days
$947.83
Détails

anti-ATXN7 Anticorps mieux référencés

  1. Human Monoclonal ATXN7 Primary Antibody pour ICC, IF - ABIN2668230 : Yvert, Lindenberg, Picaud, Landwehrmeyer, Sahel, Mandel: Expanded polyglutamines induce neurodegeneration and trans-neuronal alterations in cerebellum and retina of SCA7 transgenic mice. dans Human molecular genetics 2000 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal ATXN7 Primary Antibody pour WB - ABIN446016 : Fiszer, Wroblewska, Nowak, Krzyzosiak: Mutant CAG Repeats Effectively Targeted by RNA Interference in SCA7 Cells. dans Genes 2016 (PubMed)

  3. Cow (Bovine) Polyclonal ATXN7 Primary Antibody pour WB - ABIN2777891 : Mu, Lin, Chen, Sung, Bai, Jow: The perinatal outcomes of asymptomatic isolated single umbilical artery in full-term neonates. dans Pediatrics and neonatology 2009 (PubMed)
    Show all 2 Pubmed References

Plus d’anticorps contre ATXN7 partenaires d’interaction

Human Ataxin 7 (ATXN7) interaction partners

  1. Genetic testing showed the presence of 48 CAG repeats within one ATXN7 gene for spinocerebellar ataxia type 7 (SCA7).

  2. we observed that carriers of either ATXN7 or TBP (Montrer TBP Anticorps) alleles with relatively large CAG repeat (Montrer CELF3 Anticorps) sizes in both alleles had a substantially increased risk of lifetime depression.

  3. The intronic SNP rs6798742 is associated with ATXN7 CAG-region expansion.

  4. Results identified a chromosomal translocation between Rad51C (Montrer RAD51C Anticorps) and Ataxin-7 in colorectal tumors. The in-frame fusion transcript results in a fusion protein with molecular weight of 110 KDa. In vitro 5-Azacytidine treatment of colorectal tumor cells showed expression of the fusion gene is regulated by promoter methylation.

  5. ATXN7 may be a potential predictor of post-operative prognosis of Hepatitis B Virus-related hepatocellular carcinoma .

  6. South American cohort did not confirm the effect of the four candidate loci as modifier of onset age: mithocondrial A10398G polymorphism and CAGn at RAI1 (Montrer DOM3Z Anticorps), CACNA1A (Montrer CACNA1A Anticorps), ATXN3 (Montrer ATXN3 Anticorps), and ATXN7 genes

  7. Our study provided the clinico-genetic analysis of nine Indian SCA7 families and CAG repeat (Montrer CELF3 Anticorps) distribution analysis in diverse Indian populations showed occurrence of ATXN7-CAG intermediate alleles in a predisposed population

  8. Data show that the aggregates formed by polyQ-expanded ataxin 7 sequester ubiquitin-specific protease (USP22 (Montrer USP22 Anticorps)) through specific interactions.

  9. Two pathological polyglutamine proteins, truncated Ataxin-7 and full-length Ataxin-3 (Montrer ATXN3 Anticorps), suggest that accumulation of insoluble aggregates beyond a critical threshold could be responsible for neurotoxicity.

  10. The proband exhibited a typical phenotype of SCA7, which includes cone dystrophy and spinocerebellar ataxia.

Mouse (Murine) Ataxin 7 (ATXN7) interaction partners

  1. Spleen-specific isoform of Pax5 (Montrer PAX5 Anticorps) and Ataxin-7 can be considered as spleen-specific unique molecular markers for the evaluation of splenomegaly and lympho-proliferative disorders.

  2. Results suggest that sequestration of both enzymatic centers in SAGA upon ATXN7 poly(Q) expansion likely contributes to spinocerebellar ataxia type 7 development and progression.

  3. we found that HDAC3 (Montrer HDAC3 Anticorps) increased the posttranslational modification of normal and expanded ataxin-7.

  4. These results demonstrate that suppression of mutant ataxin-7 expression by only 50% in a polyQ disease model can have a significant impact on disease phenotypes, even when initiated after the onset of detectable behavioral deficits

  5. findings demonstrate that loss of Gcn5 (Montrer KAT2A Anticorps) functions can contribute to the time of onset and severity of SCA7 phenotypes, and suggest that non-transcriptional functions of SAGA may play a role in neurodegeneration in this disease

  6. Ataxin-7 gene expression is governed by an antisense ncRNA transcript, SCAANT1, within the ataxin-7 repeat region where the CTCF (Montrer CTCF Anticorps) binding sites reside, which regulates a previously unrecognized ataxin-7 sense promoter by convergent transcription.

  7. polyglutamine-expanded ataxin-7 upregulates the expression of Bax (Montrer BAX Anticorps) and Puma (Montrer BBC3 Anticorps) and causes apoptotic neuronal death by enhancing phosphorylation and transcriptional activity of p53 (Montrer TP53 Anticorps).

  8. study suggests that polyglutamine-expanded ataxin-7-induced transcriptional dysregulation causes cerebellar dysfunction and ataxia

  9. These results demonstrate an influence of SUMOylation on the multistep aggregation process of ATXN7 and implicate a role for ATXN7 SUMOylation in SCA7 pathogenesis.

  10. glutamine expansion stabilizes mutant ataxin-7, provide an explanation for selective neuronal vulnerability, and show that mutant ataxin-7 impairs posttetanic potentiation (PTP).

ATXN7 profil antigène

Profil protéine

The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the 'pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. This locus has been mapped to chromosome 3, and it has been determined that the diseased allele associated with spinocerebellar ataxia-7 contains 38-130 CAG repeats (near the N-terminus), compared to 7-17 in the normal allele. The encoded protein is a component of the SPT3/TAF9/GCN5 acetyltransferase (STAGA) and TBP-free TAF-containing (TFTC) chromatin remodeling complexes, and it thus plays a role in transcriptional regulation. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with anti-Ataxin 7 (ATXN7) Anticorps

  • ataxin 7 L homeolog (atxn7.L) anticorps
  • ataxin 7 (atxn7) anticorps
  • ataxin 7 (ATXN7) anticorps
  • ataxin 7 (Atxn7) anticorps
  • A430107N12Rik anticorps
  • ADCAII anticorps
  • AI627028 anticorps
  • ataxin-7 anticorps
  • MGC82940 anticorps
  • OPCA3 anticorps
  • RGD1562692 anticorps
  • Sca7 anticorps

Protein level used designations for anti-Ataxin 7 (ATXN7) Anticorps

ataxin 7 , ataxin-7 , spinocerebellar ataxia type 7 protein , spinocerebellar ataxia 7 homolog , spinocerebellar ataxia type 7 protein homolog

GENE ID SPECIES
444398 Xenopus laevis
100127691 Xenopus (Silurana) tropicalis
6314 Homo sapiens
246103 Mus musculus
361015 Rattus norvegicus
416078 Gallus gallus
484701 Canis lupus familiaris
100519688 Sus scrofa
536833 Bos taurus
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