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The protein encoded by BRPF1 is expressed ubiquitously and at the highest level in testes and spermatogonia. De plus, nous expédions Bromodomain and PHD Finger Containing, 1 Protéines (4) et beaucoup plus de produits pour cette protéine.
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Data conclude that Brpf1, coordinated by its particular set of domains, acts by multiple mechanisms to mediate Moz-dependent histone acetylation and to mark Hox genes for maintained expression throughout vertebrate development.
comparison of the clinical symptoms of individuals carrying mutations or small deletions of BRPF1 alone or SETD5 alone with those of individuals with deletions encompassing both BRPF1 and SETD5; leads to conclusion that both genes contribute to the phenotypic severity of 3p25 deletion syndrome but that some specific features, such as ptosis and blepharophimosis, are mostly driven by BRPF1 haploinsufficiency
data indicate that aberrations in the chromatin regulator gene BRPF1 cause histone H3 acetylation deficiency and a previously unrecognized intellectual disability syndrome
critical insights into the molecular mechanism of ligand binding by the BRPF1 bromodomain
MOZ-TIF2/BRPF1 complex upregulates HOX genes mediated by MOZ-dependent histone acetylation, leading to the development of leukemia.
novel interactions of the BRPF1 bromodomain with multiple acetyllysine residues on the N-terminus of histones show that it preferentially selects for H2AK5ac, H4K12ac, and H3K14ac
Identified is the PWWP domain of bromo and plant homeodomain (PHD) finger-containing protein 1 (BRPF1) as a histone H3 (H3K36me3) binding module; determined is the structure of this domain in complex with an H3K36me3-derived peptide.
BRPF1 has a role in development of fetal hematopoietic stem cells
We further demonstrate that Brpf1 loss deregulates neuronal migration, cell cycle progression and transcriptional control, thereby causing abnormal morphogenesis of the hippocampus
a crucial role of Brpf1 in controlling mouse embryo development and regulating cellular and gene expression programs
The 4-dimensional expression atlas of mouse Brpf1 serves as a valuable guide for analyzing its interaction with Moz, Morf, and Hbo1 in vivo, and for investigating whether Brpf1 functions independently of these three enzymatic epigenetic regulators.
Forebrain-specific inactivation of the Brpf1 gene causes neocortical abnormalities and partial agenesis of the corpus callosum.
BRPF2 was a novel transcript of BRPF1.
The protein encoded by this gene is expressed ubiquitously and at the highest level in testes and spermatogonia. The protein is localized within nuclei, and it is very similar in structure to two zinc finger proteins, AF10 and AF17. It is suggested that these proteins form a family of regulatory proteins. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.
bromodomain and PHD finger containing, 1
, bromodomain and PHD finger-containing protein 1
, bromodomain-containing protein, 140kD