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The product of CASC3 is a core component of the exon junction complex (EJC), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD).
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High CASC3 expression is associated with hepatocellular carcinoma.
MLN51, alone or as part of the EJC, interacts directly with the pivotal eukaryotic translation initiation factor (Montrer EIF2A Anticorps) eIF3 (Montrer EIF3A Anticorps)
MLN51 is a key factor in fibroblast-like synoviocyte hyperplasia of rheumatoid arthritis patients.
data demonstrate that metastatic lymph node(MLN)51 protein associates with exon junction complex in the nucleus and remains stably associated with messenger RNA in the cytoplasm
crystal structure of a tetrameric exon junction core complex containing the DEAD-box adenosine triphosphatase eukaryotic initiation factor 4AIII (Montrer EIF4A3 Anticorps) bound to an ATP analog, MAGOH (Montrer MAGOH Anticorps), Y14 (Montrer RBM8A Anticorps), a fragment of MLN51, and a polyuracil mRNA mimic
MLN51 is recruited into cytoplasmic aggregates known as stress granules (SGs (Montrer FBN1 Anticorps)) together with the SG-resident proteins.
data suggest that the mRNA transport machinery is conserved during evolution, and that mammalian Btz is an additional component of the dendritic ribonucleoprotein particles in hippocampal neurons
The product of this gene is a core component of the exon junction complex (EJC), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD). The encoded protein binds RNA and interacts with two other EJC core components. It is predominantly located in the cytoplasm, but shuttles into the nucleus where it localizes to nuclear speckles.
, cancer susceptibility candidate gene 3 protein
, metastatic lymph node 51
, metastatic lymph node gene 51 protein
, protein CASC3
, protein barentsz
, MLN 51 homolog
, cancer susceptibility candidate gene 3 protein homolog
, metastatic lymph node gene 51 protein homolog
, barentsz protein
, cancer susceptibility candidate 3
, Cancer susceptibility candidate gene 3 protein homolog
, Metastatic lymph node protein 51 homolog
, Protein MLN 51 homolog
, metastatic lymph node protein 51 homolog
, protein MLN 51 homolog