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CERS2 encodes a protein that has sequence similarity to yeast longevity assurance gene 1. De plus, nous expédions Ceramide Synthase 2 Kits (6) et Ceramide Synthase 2 Protéines (5) et beaucoup plus de produits pour cette protéine.
Showing 10 out of 56 products:
Human Monoclonal CERS2 Primary Antibody pour ELISA, WB - ABIN526190
Separovic, Breen, Joseph, Bielawski, Pierce, VAN Buren, Gudz: Ceramide synthase 6 knockdown suppresses apoptosis after photodynamic therapy in human head and neck squamous carcinoma cells. dans Anticancer research 2012
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Human Polyclonal CERS2 Primary Antibody pour WB - ABIN526188
Jensen, Calvert, Volpert, Kouri, Hurley, Luciano, Wu, Chalastanis, Futerman, Stegh: Bcl2L13 is a ceramide synthase inhibitor in glioblastoma. dans Proceedings of the National Academy of Sciences of the United States of America 2014
ASGR1 (Montrer ASGR1 Anticorps) can inhibit the activity of V-ATPase (Montrer ATP6V1H Anticorps) by interacting with LASS2, thereby suppressing the metastatic potential of hepatoma cells.
Data show that 1-acylglycerol-3-phosphate O-acyltransferase 9 (AGPAT9 (Montrer AGPAT9 Anticorps)) inhibit cell growth by regulating expression of KLF4 (Montrer KLF4 Anticorps)/LASS2/V-ATPase (Montrer ATP6V1H Anticorps) proteins in breast cancer.
these results indicate that miR (Montrer MLXIP Anticorps)-9 upregulation might be associated with malignant phenotype of bladder cancer. miR (Montrer MLXIP Anticorps)-9 promotes chemoresistance of bladder cancer cells by target LASS2.
Data show that CERS2 expression was markedly different between various breast cancer cells and inversely correlated with cell invasion.
silencing of TMSG1 increased V-ATPase (Montrer ATP6V1H Anticorps) activity, decreased extracellular pH and in turn the activation of secreted MMP-2 (Montrer MMP2 Anticorps), which ultimately promoted metastasis capacity of breast cancer cell.
Results confirmed that TMSG1 is a potential metastasis suppressor gene, and suggested that the mechanism involved the induction of apoptosis and inhibition of cell proliferation via a caspase (Montrer CASP3 Anticorps)-dependent mitochondrial pathway.
the vacuolar ATPase (V-ATPase (Montrer DNAH8 Anticorps)) activity and extracellular hydrogen ion concentration were significantly decreased and the activity of secreted matrix metalloproteinase-2 (MMP-2 (Montrer MMP2 Anticorps)) was downregulated in MCF-7 cells overexpressing LASS2/TMSG1
the inhibitory effect of the LASS2 on growth, invasion and metastasis of prostate cancer cells
Co-expression of CerS2 with CerS4 (Montrer CERS4 Anticorps)/CerS6 (Montrer CERS6 Anticorps) reversed the inhibitory effect of long chain ceramides on cell proliferation and the induction of apoptosis. we detected no effect on cell proliferation.
expression and role of ceramide synthase-2 in the lung
LASS2 plays an important role in efficient liver regeneration in response to partial hepatectomy.
Deletion of CerS2 strongly reduced very long-chain ceramides (Cer24:0, 24:1) but concomitantly increased long-chain ceramides and sphinganine in plasma and colon tissue. In naive CerS2(-/-) mice, the expression of tight junction proteins including ZO-1 (Montrer TJP1 Anticorps) was almost completely lost in the colon epithelium, leading to increased membrane permeability. Ceramide synthase 2 deficiency aggravates dextran induced colitis in mice.
this study shows that Cers2 limits the levels of S1P (Montrer S1PR1 Anticorps) in thymus and blood to maintain functional S1P (Montrer S1PR1 Anticorps) gradients that mediate thymocyte emigration into the circulation
that only LCBs, the substrates common for all of the CerS isoforms, but not ceramides and complex sphingolipids, were restored to the wild-type levels in the Cers2-rescued Cers1 (Montrer CERS1 Anticorps) mutant mouse brains.
CerS1 (Montrer CERS1 Anticorps), -2, and -6 are hyperacetylated in the mitochondria of SIRT3 (Montrer SIRT3 Anticorps)-null mice.
Haploinsufficiency for this enzyme altered the pattern of ceramide acylation in the liver without affecting total ceramide levels, replacing very-long-chain ceramides with long-chain C16-ceramides.
Development of pheochromocytoma in ceramide synthase 2 null mice
our data strongly indicate that G-CSF (Montrer CSF3 Anticorps)-induced CXCR2 (Montrer CXCR2 Anticorps) expression is regulated in a CerS2-dependent manner and that CerS2 thereby promotes the migration of neutrophils, thus, contributing to inflammation and the development of EAE and MS.
Data indicate that the augmented rate of death of ceramide synthase 2 (CerS2) null mice is due to elevated levels of tumor necrosis factor alpha (TNFalpha (Montrer TNF Anticorps)) secretion as a result of enhanced activity of TNFalpha (Montrer TNF Anticorps)-converting enzyme (TACE (Montrer ADAM17 Anticorps)).
CerS2-deficient kidneys were completely depleted of phytosphingosine-containing cortical sulfatides without any compensatio
This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have been described.
LAG1 homolog, ceramide synthase 2
, LAG1 longevity assurance 2
, longevity assurance (LAG1, S. cerevisiae) homolog 2
, tumor metastasis-suppressor gene 1 protein
, LAG1 longevity assurance homolog 2
, TRAM homolog 3
, longevity assurance homolog 2
, translocating chain-associating membrane protein homolog 3