anti-Complement Factor H-Related 3 (CFHR3) Anticorps

The protein encoded by CFHR3 is a secreted protein, which belongs to the complement factor H-related protein family. De plus, nous expédions CFHR3 Kits (6) et CFHR3 Protéines (5) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
CFHR3 624286  
CFHR3 10878 Q02985
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Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Humain Lapin Inconjugué IHC, WB ABIN6273207 at 1/100 staining Human melanoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. Western blot analysis of extracts of human heart tissue, using CFHR3 antibody. 100 μL 11 to 12 Days
Humain Lapin Inconjugué IF, IHC, WB Western blot analysis of extracts of various cells, using CFHR3 antibody. Immunofluorescence analysis of A549 cell using CFHR3 antibody. Blue: DAPI for nuclear staining. 100 μL 11 to 13 Days
Humain Lapin Inconjugué WB Western blot analysis of extracts of various cell lines, using CFHR3 antibody. 200 μL 12 to 14 Days
Humain Lapin Inconjugué IF/ICC, WB 100 μL 11 to 18 Days
Humain Lapin Inconjugué IC, IF, WB Immunofluorescent analysis of FHR3 staining in A549 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody i Western blot analysis of FHR3 expression in A549 (A), HepG2 (B), NIH3T3 (C), mouse liver (D), rat liver (E) whole cell lysates. 200 μL 13 to 14 Days
Humain Lapin Inconjugué WB   100 μL 11 to 14 Days
Cheval Lapin Inconjugué WB   100 μL 2 to 3 Days
Humain Lapin Inconjugué IF Immunofluorescence analysis of A549 cells using CFHR3 antibody (ABIN6294036). Blue: DAPI for nuclear staining. 50 μL 11 to 13 Days
Humain Lapin Inconjugué ELISA, IHC, IP, WB   100 μg 13 to 16 Days
Humain Lapin Inconjugué ELISA, WB   100 μL 11 to 16 Days

Plus d’anticorps contre CFHR3 partenaires d’interaction

Human Complement Factor H-Related 3 (CFHR3) interaction partners

  1. In conclusion, the CFHR3,1D genotype did not associate with progression toward CKD stages 3 and 5 in our white population of patients with IgAN, although it did associate with a reduced level of glomerular immune deposits.

  2. These data suggest that increased plasma levels of FHR-3, altering the balance between factor H (FH) and FHR-3, likely impact the FH regulatory functions and contribute to the development of atypical hemolytic-uremic syndrome .

  3. We conclude that the relationship between complement-regulatory proteins CFHR1 and CFHR3 and response to anti-CD20 mAb therapy varies based on the specific anti-CD20 mAb used.

  4. To our knowledge, this is the first evaluation of the involvement of the CFHR3/CFHR1 deletion and age-related macular degeneration in CFH Y402H polymorphism Brazilian patients.

  5. These data provide evidence that FHR3, which is absent in patients with the autoimmune form of hemolytic uremic syndrome, is involved in B cell regulation

  6. Exploratory analyses of clinical and histopathologic parameters using the Oxford classification criteria revealed a suggestive association of CFHR3,1Delta with reduced tubulointerstitial injury. These data indicate that dysregulated activity of the alternative complement pathway contributes to IgAN pathogenesis in both Asians and Europeans and implicate CFHR3,1Delta as the functional allele at this locus

  7. We describe a novel CFH/CFHR3 hybrid gene secondary to a de novo 6.3-kb deletion that arose through microhomology-mediated end joining rather than nonallelic homologous recombination. We confirmed a transcript from this hybrid gene and showed a secreted protein product that lacks the recognition domain of factor H and exhibits impaired cell surface complement regulation

  8. Next-generation sequencing of the CFH region identified putatively functional variants (missense, splice site and indel) on the four common haplotypes. We found no expression of any of the five CFH-related genes in the retina or RPE/Choroid/Sclera, in contrast to the liver, which is the main source of the circulating proteins.[CFHR3]

  9. Studies indicate that complement factor H-related proteins (FHR1-5) may enhance complement activation, with important implications for the role of these proteins in disease.

  10. These results suggest that the combination of quantitative and qualitative variations in the complement proteins encoded by CFH, CFHR3 and CFHR1 genes is key for the association of these haplotypes with disease.

  11. Genetic variants in CFH, CFHR3, and CFHR1 affect complement activation and thereby predispose patients to develop IgA nephropathy.

  12. Prompt use of immunosuppressive agents and plasma exchanges are useful for improving outcomes in pediatric patients with anti-complement factor H-associated HUS.

  13. Atypical haemolytic-uraemic syndrome due to heterozygous mutations of CFH/CFHR1-3 and complement factor H 479.

  14. we have assessed the relationship between GA and previously identified AMD-associated variants of genes (CFH, CFB, C3, FHR1, FRH3, and ARMS2/HTRA).

  15. genetic variations in CFH and its related genes may contribute to hypertension risk in Chinese Hans

  16. A hybrid CFHR3-1 gene causes familial C3 glomerulopathy.

  17. Significant association was identified for the CFHR3-1 deletion in age-related macular degeneration cases, for both neovascular disease and geographic atrophy.

  18. A novel hybrid CFH/CFHR3 gene generated by a microhomology-mediated deletion is associated with familial atypical hemolytic uremic syndrome.

  19. Data show that 698 CNPs loci overlap with known disease-associated or pharmacogenetic-related genes such as CFHR3, CFHR1, GSTTI and UGT2B17.

  20. In this matched subset of Age-Related Eye Disease Study (AREDS) subjects, after adjusting for 2 known risk variants in CFH, CNP147 deletion statistically associates with diminished risk for AMD.

CFHR3 profil antigène

Profil protéine

The protein encoded by this gene is a secreted protein, which belongs to the complement factor H-related protein family. It binds to heparin, and may be involved in complement regulation. Mutations in this gene are associated with decreased risk of age-related macular degeneration, and with an increased risk of atypical hemolytic-uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with CFHR3

  • complement factor H-related 3 (Cfhr3) anticorps
  • complement factor H related 3 (CFHR3) anticorps
  • CFHL3 anticorps
  • DOWN16 anticorps
  • EG624286 anticorps
  • FHR-3 anticorps
  • FHR3 anticorps
  • HLF4 anticorps

Protein level used designations for CFHR3

H factor-like 4 , H factor-like protein 3 , complement factor H-related protein 3

624286 Mus musculus
10878 Homo sapiens
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