DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1) Kits ELISA

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. De plus, nous expédions DNA (Cytosine-5-)-Methyltransferase 3 Like Anticorps (224) et DNA (Cytosine-5-)-Methyltransferase 3 Like Protéines (12) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
TRDMT1 54427 Q9CWR8
Anti-Humain TRDMT1 TRDMT1 29947 Q9UJW3
Anti-Rat TRDMT1 TRDMT1 309680 Q1LZ50
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Catalogue No. Reactivité Sensibilité Gamme Images Quantité Fournisseur Livraison Prix Détails
Souris 0.094 ng/mL 0.156-10 ng/mL Typical standard curve 96 Tests Connectez-vous pour afficher 12 to 14 Days

Plus Kits ELISA pour DNA (Cytosine-5-)-Methyltransferase 3 Like partenaires d'interaction

Mouse (Murine) DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1) interaction partners

  1. The Sirt1 (Montrer SIRT1 Kits ELISA) protein suppressed transcription of Dnmt3l.

  2. The Dnmt3l mutation greatly reduced DNA methylation levels at most retrotransposons, but its impact on their RNA abundance was limited in prospermatogonia. In Pld6 mutant germ cells, although only a few retrotransposons exhibited reduced DNA methylation, many showed increased expression at the RNA level.

  3. Dnmt3l-KO donor cells may offer a more permissive epigenetic state that is beneficial for Nuclear transfer reprogramming

  4. By interacting with TRIM28 (Montrer TRIM28 Kits ELISA), DNMT3L can attract various enzymes to form a DNMT3L-induced repressive complex to remove active marks and add repressive marks to histone proteins.

  5. Hypomethylation of highly methylated CpG islands was caused by the downregulation of Dnmt3L and Dnmt3a (Montrer DNMT3A Kits ELISA) due to hepatitis B X-protein bound to their promoters.

  6. DNMT3L is required to delicately balance the cycling and quiescence of spermatogonial progenitor cells

  7. Study demonstrates that Dnmt3L interacts with the Polycomb PRC2 complex in competition with the DNA methyltransferases Dnmt3a (Montrer DNMT3A Kits ELISA) and Dnmt3b (Montrer DNMT3B Kits ELISA) to maintain low methylation levels at the Histone 3 H3K27me3 regions.

  8. Data indicate that expression of Dnmt3a (Montrer DNMT3A Kits ELISA), Dnmt3b (Montrer DNMT3B Kits ELISA), Dnmt3L as well as maintenance Dnmt1o (Montrer DNMT1 Kits ELISA) in oocytes and zygotes was not disrupted.

  9. Reduced expression of DNMT3L in male germ cells, associated with haploinsufficiency of the paternal-effect gene Dnmt3L, results in abnormal hypomethylation of prenatal germline progenitor cells.

  10. The maternal store of Dnmt3L is not involved in embryonic de novo methylation.

Human DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1) interaction partners

  1. DNMT3L overexpression is associated with Down syndrome.

  2. the present study has demonstrated that variations in the DNMT3L gene do not contribute to stage I-II endometriosis-associated infertility.

  3. DNMT3L rs2070565 (genotype P = 0.007, allele P = 0.0026) confers an increased risk of developing schizophrenia at an early age in individuals with family history.

  4. crystal structures of DNMT3A (Montrer DNMT3A Kits ELISA)-DNMT3L (autoinhibitory form) and DNMT3A (Montrer DNMT3A Kits ELISA)-DNMT3L-H3 (active form) complexes at 3.82 and 2.90 A resolution, respectively

  5. DNMT3L can address DNMT3A (Montrer DNMT3A Kits ELISA)/B to specific sites by directly interacting with TFs that do not directly interact with DNMT3A (Montrer DNMT3A Kits ELISA)/B

  6. CpG island encompassing the promoter and first exon of human DNMT3L gene is a PcG/TrX response element

  7. DNMT3L is one of the key players in de novo DNA methylation of imprinting control elements and retrotransposons, which occurs after genome-wide epigenetic erasure during germ cell development. (Review)

  8. SNP rs2070565, as well as haplotypes AAA (Montrer APP Kits ELISA) and GAA (Montrer GAA Kits ELISA), may be associated with male infertility; DNMT3L may contribute to azoospermia susceptibility in humans

  9. Genetic polymorphisms of DNMT3L involved in hypermethylation of chromosomal ends are associated with greater risk of developing ovarian endometriosis.

  10. mutation analysis of SYCP3, DNMT3L and MSH4 in patients with maturation arrest of spermatogenesis and couples with recurrent miscarriages.

DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1) profil antigène

Antigen Summary

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with TRDMT1

  • DNA methyltransferase 3 like (DNMT3L) anticorps
  • DNA (cytosine-5-)-methyltransferase 3-like (Dnmt3l) anticorps
  • DNA methyltransferase 3 like (Dnmt3l) anticorps
  • D6Ertd14e anticorps
  • DNMT3L anticorps
  • ecat7 anticorps

Protein level used designations for TRDMT1

DNA (cytosine-5-)-methyltransferase 3-like , cytosine-5-methyltransferase 3-like protein , DNA (cytosine-5)-methyltransferase 3-like , human cytosine-5-methyltransferase 3-like protein

100050680 Equus caballus
470099 Pan troglodytes
613785 Bos taurus
608536 Canis lupus familiaris
54427 Mus musculus
29947 Homo sapiens
309680 Rattus norvegicus
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