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CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. De plus, nous expédions DNMT3A Protéines (6) et DNMT3A Kits (2) et beaucoup plus de produits pour cette protéine.
Showing 10 out of 282 products:
Human Monoclonal DNMT3A Primary Antibody pour ChIP, CyTOF - ABIN266067
Chen, Ueda, Xie, Li: A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation. dans The Journal of biological chemistry 2002
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Human Polyclonal DNMT3A Primary Antibody pour ICC, IF - ABIN151733
Robert, Morin, Beaulieu, Gauthier, Chute, Barsalou, MacLeod: DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells. dans Nature genetics 2003
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Human Polyclonal DNMT3A Primary Antibody pour IHC (p), WB - ABIN387881
Xie, Wang, Okano, Nogami, Li, He, Okumura, Li: Cloning, expression and chromosome locations of the human DNMT3 gene family. dans Gene 1999
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Human Monoclonal DNMT3A Primary Antibody pour ChIP, WB - ABIN2668262
Karius, Schnekenburger, Ghelfi, Walter, Dicato, Diederich: Reversible epigenetic fingerprint-mediated glutathione-S-transferase P1 gene silencing in human leukemia cell lines. dans Biochemical pharmacology 2011
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Human Polyclonal DNMT3A Primary Antibody pour IF (p), IHC (p) - ABIN669336
Zhao, Hou, Chen, Shao, Zhu, Bu, Gu, Li, Zhang, Du, Fu, Kong, Luo, Long, Li, Deng, Zhao, Cen: Prenatal cocaine exposure impairs cognitive function of progeny via insulin growth factor II epigenetic regulation. dans Neurobiology of disease 2015
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Mouse (Murine) Polyclonal DNMT3A Primary Antibody pour IHC, WB - ABIN2668264
Tognini, Napoli, Tola, Silingardi, Della Ragione, DEsposito, Pizzorusso: Experience-dependent DNA methylation regulates plasticity in the developing visual cortex. dans Nature neuroscience 2015
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Human Polyclonal DNMT3A Primary Antibody pour ICC, IF - ABIN4305707
Quist, Jin, Zhu, Smith-Fry, Capecchi, Jones: The impact of osteoblastic differentiation on osteosarcomagenesis in the mouse. dans Oncogene 2015
Human Monoclonal DNMT3A Primary Antibody pour FACS, ICC - ABIN252483
Sato, Kondo, Arai: The orphan nuclear receptor GCNF recruits DNA methyltransferase for Oct-3/4 silencing. dans Biochemical and biophysical research communications 2006
Human Polyclonal DNMT3A Primary Antibody pour WB - ABIN2668283
Chang, Sun, Kokura, Horton, Fukuda, Espejo, Izumi, Koomen, Bedford, Zhang, Shinkai, Fang, Cheng: MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a. dans Nature communications 2011
Human Monoclonal DNMT3A Primary Antibody pour ICC, IF - ABIN2668287
Felle, Joppien, Németh, Diermeier, Thalhammer, Dobner, Kremmer, Kappler, Längst: The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1. dans Nucleic acids research 2011
Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1 (Montrer DNMT1 Anticorps), Dnmt3a, Hdac1 (Montrer HDAC1 Anticorps), Kdm3a (Montrer KDM3A Anticorps) and Uhrf1 (Montrer UHRF1 Anticorps) were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).
we found that DNMT3A was responsible for the down-regulation of miR (Montrer MLXIP Anticorps)-105 in gastric cancer cells
Taken together, these data demonstrate that adipose Dnmt3a is a novel epigenetic mediator of insulin (Montrer INS Anticorps) resistance in vitro and in vivo.
Low frequency of DNMT3A mutations in pediatric T-ALL is in striking contrast to adult T-ALL and renders the necessity for the search of other candidate prognostic markers. Combined Sanger sequencing-HRM approach offers a cost-effective option for genotyping DNMT3A coding sequence, with potential clinical application in other hematological malignancies.
2.65-angstrom crystal structure of the DNMT3A-DNMT3L (Montrer TRDMT1 Anticorps)-DNA complex in which two DNMT3A monomers simultaneously attack two cytosine-phosphate-guanine (CpG) dinucleotides, with the target sites separated by 14 base pairs within the same DNA duplex; mechanistic basis for DNMT3A-mediated DNA methylation (Montrer HELLS Anticorps) and establishment of its aetiological link to human disease
based on the investigation of previously reported variants in patients with Tatton-Brown-Rahman syndrome , we found overlap in the spectrum of DNMT3A variants observed in this disorder and somatic variants in hematological malignancies
The emodininduced downregulation of UHRF1 (Montrer UHRF1 Anticorps) led to an increase in the level of DNA methyltransferase 3A.
Data suggest that miR (Montrer MLXIP Anticorps)-200b-3p may exhibit targeting and suppressive effects on DNA methyltransferase 3A (DNMT3A).
Prostaglandin E2 promotes the acquisition of DNMT3A-dependent tolerogenic functions in human myeloid-derived suppressor cells.
human mammary epithelial cells reprogramming is dependent on gene silencing by the DNA methyltransferase (Montrer DNMT1 Anticorps) DNMT3A and loss of histone transcriptional marks following downregulation of the methyltransferase DOT1L (Montrer DOT1L Anticorps).
the immunohistochemical expressions of Klotho (Montrer KL Anticorps) and DNMT3a in tissues obtained from oral dysplasia and oral squamous cell carcinoma, is reported.
Among 18 genotypes analyzed, we were unable to record any significant differences in 5-methyl-2'-deoxycytidine levels, which suggested that age-related changes in global DNA methylation (Montrer HELLS Anticorps) content are rather a function of time, and not a genetic component.
The effect of p53 (Montrer TP53 Anticorps) expression on the development of cloned embryos, and its interaction with HDAC1 (Montrer HDAC1 Anticorps) and DNMT3A are reported.
The expression levels of DNMT3a and DNMT3b (Montrer DNMT3B Anticorps) were associated with several beef quality traits.
individual pain vulnerability may be inherent mostly in the emotional/affective component of chronic pain and remain consistent in different aspects of negative emotion, in which adaptive changes in the function of DNA methyltransferase 3a for DNA methylation (Montrer HELLS Anticorps) in central amygdala may play an important role.
The aim of the present study is to investigate spatial and temporal expression levels and subcellular localizations of the DNMT1 (Montrer DNMT1 Anticorps), DNMT3A, and DNMT3B (Montrer DNMT3B Anticorps) proteins in the mouse germinal vesicle (GV) and metaphase II (MII) oocytes, and early embryos from 1-cell to blastocyst stages.
our Dnmt3a R878H mice have shown that leukemic cells have altered gene expression and epigenetic regulatory patterns contributing to the growth/survival advantage over WT mice.The present study found that the DNMT3A mutation contributed to hypomethylation in the gene body region of mTOR (Montrer FRAP1 Anticorps) in Dnmt3aR878H/WT mice.
Knockdown of DNMT3A or DNMT1 (Montrer DNMT1 Anticorps) protected neurons against mutant Htt (Montrer HTT Anticorps)-induced toxicity, together demonstrating a requirement for DNMTs in mutant Htt (Montrer HTT Anticorps)-triggered neuronal death and suggesting a neurodegenerative mechanism based on DNA methylation (Montrer HELLS Anticorps)-mediated transcriptional repression.
Data demonstrate that DNMT3A and DNA methylation (Montrer HELLS Anticorps) are key modulators of mast cell responsiveness to acute and chronic stimulation.
These data suggest that DNMT3a is required for nerve injury-induced and MBD1 (Montrer DPEP1 Anticorps)-mediated epigenetic silencing of the MOR (Montrer OPRM1 Anticorps) and KOR (Montrer OPRK1 Anticorps) in the injured DRG. DNMT3a inhibition may serve as a promising adjuvant therapy for opioid use in neuropathic pain management.
Data show that conditional deletion of Dnmt3a and simultaneous "knock in" of Flt3ITD/+, cooperate to drive leukemia development at a faster rate than Dnmt3a loss alone.
Deletion of DNMT3a in postnatal forebrain neurons does no alter affective behavior.
Altogether, the authors demonstrate that Dnmt3a and Dnmt3b (Montrer DNMT3B Anticorps) protect the epidermis from tumorigenesis and that squamous carcinomas are sensitive to inhibition of PPAR-gamma (Montrer PPARG Anticorps).
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms.
DNA (cytosine-5-)-methyltransferase 3 alpha
, DNA cytosine methyltransferase 3 alpha
, DNA (cytosine-5)-methyltransferase 3A
, DNA methyl transferase alpha
, DNA methyltransferase 3A
, DNA MTase HsaIIIA
, DNA cytosine methyltransferase 3A2
, DNA-methyltransferase 3a
, DNA MTase MmuIIIA
, DNA methyltransferase MmuIIIA