anti-DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) Anticorps

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. De plus, nous expédions DNMT3A Kits (12) et DNMT3A Protéines (7) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
DNMT3A 1788 Q9Y6K1
DNMT3A 13435 O88508
DNMT3A 444984 Q1LZ53
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Top anti-DNMT3A Anticorps sur

Showing 10 out of 305 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Souris Inconjugué ChIP, CyTOF, FACS, ICC, IF, IHC (p), IHC (wm), WB Western blot analysis for Dnmt3a using ABIN266067 at 2 ug/ml against 10 ?g of 293 cell lysate transfected with either mouse Dnmt3a (lane A) or mouse Dnmt3b (lane B). Immuno-staining of Dnmt3a using ABIN266067 at 5 ug/ml dilution on cultured HeLa cells. The nucleic staining is shown in most of the cells. 0.1 mg Connectez-vous pour afficher 7 to 9 Days
Humain Lapin Inconjugué IHC (p), WB Western blot analysis of anti-Dnmt3a Pab (ABIN387881) in T47-D cell lysate. Dnmt3a (Arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. Lysates from thymus tissue after radiation were subjected to WB using antibody against DNMT3a. CT, control animals. FR, animals subjected to fractionated exposure. AC, acutely exposed animals. All sample loading was normalized to protein content. Representative Western blots from three independent experiments are shown. each lane represents a protein extract of a thymus of one animal. (Mol. Cancer Res. 2005 Oct 01.3(10):553-561) 400 μL Connectez-vous pour afficher 10 to 11 Days
Souris Lapin Inconjugué IHC, WB Immunohistochemistry of paraffin-embedded human stomach cancer using DNMT3A antibody at dilution of 1:200 (x400 lens) 100 μL Connectez-vous pour afficher 13 to 14 Days
Humain Lapin Inconjugué ICC, IF, IHC, IHC (p), WB Immunohistochemistry-Paraffin: DNMT3A Antibody [NBP1-85961] - Staining of human liver cancer tumor cells (nuclear) (52 year old female) Immunohistochemistry-Paraffin: DNMT3A Antibody [NBP1-85961] - Staining of human testis shows nuclear positivity in Leydig cells and cells in seminiferous ducts (46 year old male) 0.1 mL Connectez-vous pour afficher 10 to 13 Days
Humain Lapin Inconjugué WB 100 μg Connectez-vous pour afficher 2 to 3 Days
Boeuf (Vache) Lapin Inconjugué WB Host:  Rabbit  Target Name:  DNMT3A  Sample Type:  Lung Tumor lysates  Antibody Dilution:  1.0ug/ml Host:  Mouse  Target Name:  DNMT3A  Sample Tissue:  Mouse Spleen  Antibody Dilution:  1ug/ml 100 μL Connectez-vous pour afficher 2 to 3 Days
Humain Lapin Inconjugué ICC, IF, IHC (p), IP, IHC, WB Western blot analysis using ABIN151733 to detect overexpressed DNMT3A level in HCT-116 cells. Lane 1: 40 ug of nuclear extract from untreated HCT-116 cells. Lane 2: 40 ug of Nuclear extract from HCT-116 cells overexpressing DNMT3A. Immunohistochemistry: Dnmt3a Antibody [ABIN151733] - Dnmt3a antibody was tested in human testis using DAB with hematoxylin counterstain. 0.1 mL Connectez-vous pour afficher 7 to 9 Days
Humain Lapin Inconjugué IF/ICC, IHC, WB Western blot analysis of extracts of various cell lines, using DNMT3A antibody (ABIN5971621). Immunohistochemistry of paraffin-embedded rat lung using DNMT3A Antibody (ABIN5971621) at dilution of 1/100 (40x lens). 100 μL Connectez-vous pour afficher 11 to 16 Days
Humain Lapin Inconjugué IHC (p), WB Western blot analysis of anti-DNMT3A Antibody (Center D472) (ABIN387882) in Jurkat cell line lysates (35 µg/lane).DNMT3A(arrow) was detected using the purified polyclonal antibody (1:60dilution). Formalin-fixed and paraffin-embedded human kidney tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Connectez-vous pour afficher 10 to 11 Days
Humain Souris Inconjugué ELISA, FACS, IHC, WB Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng) Western blot analysis using DNMT3A mAb against human DNMT3A (AA: 46-180) recombinant protein. (Expected MW is 40 kDa) 0.1 mg Connectez-vous pour afficher 8 to 11 Days

anti-DNMT3A Anticorps mieux référencés

  1. Human Monoclonal DNMT3A Primary Antibody pour ChIP, CyTOF - ABIN266067 : Chen, Ueda, Xie, Li: A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation. dans The Journal of biological chemistry 2002 (PubMed)
    Show all 90 Pubmed References

  2. Human Polyclonal DNMT3A Primary Antibody pour ICC, IF - ABIN151733 : Robert, Morin, Beaulieu, Gauthier, Chute, Barsalou, MacLeod: DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells. dans Nature genetics 2003 (PubMed)
    Show all 11 Pubmed References

  3. Human Polyclonal DNMT3A Primary Antibody pour IHC (p), WB - ABIN387881 : Xie, Wang, Okano, Nogami, Li, He, Okumura, Li: Cloning, expression and chromosome locations of the human DNMT3 gene family. dans Gene 1999 (PubMed)
    Show all 12 Pubmed References

  4. Human Monoclonal DNMT3A Primary Antibody pour ChIP, IF - ABIN531981 : Du, Zhou, Liu, Jiang, Wang, Hu, Qi, Zhong, Wang, Li: Arsenic induces functional re-expression of estrogen receptor ? by demethylation of DNA in estrogen receptor-negative human breast cancer. dans PLoS ONE 2012 (PubMed)
    Show all 7 Pubmed References

  5. Human Polyclonal DNMT3A Primary Antibody pour IHC (p), ELISA - ABIN543166 : Koturbash, Boyko, Rodriguez-Juarez, McDonald, Tryndyak, Kovalchuk, Pogribny, Kovalchuk: Role of epigenetic effectors in maintenance of the long-term persistent bystander effect in spleen in vivo. dans Carcinogenesis 2007 (PubMed)
    Show all 3 Pubmed References

  6. Human Monoclonal DNMT3A Primary Antibody pour ChIP, WB - ABIN2668262 : Karius, Schnekenburger, Ghelfi, Walter, Dicato, Diederich: Reversible epigenetic fingerprint-mediated glutathione-S-transferase P1 gene silencing in human leukemia cell lines. dans Biochemical pharmacology 2011 (PubMed)
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  7. Human Polyclonal DNMT3A Primary Antibody pour IHC, WB - ABIN6673336 : Zhao, Lei, Zhang, Zheng, Wang, Zhao, Li, Ye, Li, Wei, Wu: Global histone modification profiling reveals the epigenomic dynamics during malignant transformation in a four-stage breast cancer model. dans Clinical epigenetics 2016 (PubMed)
    Show all 3 Pubmed References

  8. Mouse (Murine) Polyclonal DNMT3A Primary Antibody pour IHC, WB - ABIN3022834 : Xi, Gao, Yang, Ye, Zhang, Wu, Jiang, Zhang: Anticancer drugs induce hypomethylation of the acetylcholinesterase promoter via a phosphorylated-p38-DNMT1-AChE pathway in apoptotic hepatocellular carcinoma cells. dans The international journal of biochemistry & cell biology 2016 (PubMed)
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  9. Human Polyclonal DNMT3A Primary Antibody pour IF (p), IHC (p) - ABIN669336 : Zhao, Hou, Chen, Shao, Zhu, Bu, Gu, Li, Zhang, Du, Fu, Kong, Luo, Long, Li, Deng, Zhao, Cen: Prenatal cocaine exposure impairs cognitive function of progeny via insulin growth factor II epigenetic regulation. dans Neurobiology of disease 2015 (PubMed)
    Show all 2 Pubmed References

  10. Mouse (Murine) Polyclonal DNMT3A Primary Antibody pour IHC, WB - ABIN2668264 : Tognini, Napoli, Tola, Silingardi, Della Ragione, DEsposito, Pizzorusso: Experience-dependent DNA methylation regulates plasticity in the developing visual cortex. dans Nature neuroscience 2015 (PubMed)
    Show all 2 Pubmed References

Plus d’anticorps contre DNMT3A partenaires d’interaction

Pig (Porcine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) interaction partners

  1. Study demonstrated that overexpression of DNMT3A promoted the expression of cell proliferation markers but significantly decreased the expression of p21 to repress cell proliferation by the methylation of p21 promoter. Moreover, overexpression of DNMT3A decreased lipid accumulation and significantly down-regulated the levels of adipogenic marker genes through the methylation of PPARg promoter.

  2. Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1, Dnmt3a, Hdac1, Kdm3a and Uhrf1 were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).

Cow (Bovine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) interaction partners

  1. The effect of p53 expression on the development of cloned embryos, and its interaction with HDAC1 and DNMT3A are reported.

  2. The expression levels of DNMT3a and DNMT3b were associated with several beef quality traits.

Horse (Equine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) interaction partners

  1. Among 18 genotypes analyzed, we were unable to record any significant differences in 5-methyl-2'-deoxycytidine levels, which suggested that age-related changes in global DNA methylation content are rather a function of time, and not a genetic component.

Human DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) interaction partners

  1. DNMT3A mRNA was negatively correlated with serum 25(OH)D and positively correlated with VDR DNA methylation in colorectal cancer.

  2. An association was found between DNMT3A mutations and epileptic encephalopathy susceptibility.

  3. Our findings suggest that DNMT3A may be a susceptibility gene for paragangliomas and, if confirmed in future studies, would represent the first example of gain-of-function mutations affecting a DNA methyltransferase gene involved in cancer predisposition.

  4. review recent studies on acute myeloid leukemia with a focus on the clinical features and functional roles of DNMT3A mutations, and discuss future challenges to effectively cure DNMT3A mutation-associated hematopoietic disorders[review]

  5. prognostic impact of DNMT3A R882 mutations at diagnosis among mainly older (>60 years) AML patients who underwent non-myeloablative -HSCT.

  6. data indicates that DNMT3AR882H quantification is an unreliable tool for MRD monitoring since it does not reflect disease status in AML, and may rather represent the CHIP substrate.

  7. DNMT3A/3B expression increases progressively from EEC to NEEC and is correlated with poor survival. The mechanisms underlying low ER/PR expression might be distinct in EEC vs. NEEC. In EEC, methylation related to DNMT3A/3B overexpression might play a major role in ER/PR downregulation.

  8. The interaction of the DNMT3A PWWP domain with H3K36me2 and H3K36me3 normally limits DNA methylation.

  9. Distinct clinical and biological implications of various DNMT3A mutations in myeloid neoplasms.

  10. Blastic plasmacytoid dendritic cell neoplasm with unusual morphology, MYC rearrangement and TET2 and DNMT3A mutations.

  11. In this study, we found that DNMT3AR882-associated hypomethylation was preserved in patient-derived AML xenografts with DNMT3AR882, which displayed the same global and focal hypomethylation phenotypes as primary patient samples.

  12. The progress of arterial calcification is regulated by the miR-204/DNMT3a regulatory circuit.

  13. DNMT3A mutation predicts unfavorable outcomes in myelodysplastic syndrome and was stable during disease evolutions. It may thus be a potential biomarker to predict prognosis.

  14. AML patients with FLT3-ITD and DNMT3A R882 double mutations had a very high cumulative recurrence rate and low overall survival, leukocyte-free survival after transplantation

  15. Targeting the DNMT3Ab/Snail/E-cadherin axis may provide a promising therapeutic strategy in the treatment of metastatic GC with high DNMT3Ab expression.

  16. both DNMT3A-WT and R882H/C mutants interacted with PRDX2; and R882C/H mutation-induced hypomethylation increased PRDX2 expression which enhanced cell proliferation and growth with impairment of apoptosis, thereby contributing to leukemogenesis.

  17. In the absence of a concomitant DNA methyltransferase 3A (DNMT3A) mutation, there was no significant difference in overall survival between fms-like tyrosine kinase 3A tandem repeat (FLT3-ITD) positive and FLT3-ITD negative patients.

  18. mutations in the epigenetic regulators TET2 and DNMT3A corresponded to high ARG1 expression and activity. These findings suggest ARG1 is a biomarker of immune dysregulation in early MDS and CMML

  19. results show DNMT3 mutations as additional somatic events in breast implant associated anaplastic large cell lymphoma.

  20. DNMT1 expression associated with extracapsular nodal extension. DNMT3A and DNMT3B expression showed a significant association with high histologic grade and DNMT3A expression was also associated with HER-2 status. overexpression of DNMT3B remained as an independent and unfavorable prognostic factor for disease free survival.

Mouse (Murine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) interaction partners

  1. The results of this study identify Dnmt3a2 as an important epigenetic regulator needed for the establishment of central sensitization. Targeting expression or function of Dnmt3a2 may be suitable for the treatment of chronic pain.

  2. SUV39H1/DNMT3A-dependent methylation of the RB1 promoter stimulates PIN1 expression and melanoma development.

  3. The progress of arterial calcification is regulated by the miR-204/DNMT3a regulatory circuit.

  4. Deletion of the de novo DNA methyltransferases Dnmt3a and Dnmt3b in mouse B cells results in normal B cell development and maturation, but increased cell activation and expansion of the germinal center B cell and plasma cell populations upon immunization.

  5. the upregulation of DNMT3A emerges as a prominent molecular event triggered by ethanol, driven by the generation of reactive oxygen species.

  6. Dnmt3a appears to regulate satellite cell differentiation via DNA methylation. This mechanism may play a role in the decreased regeneration capacity during atrophy such as in aged sarcopenia.

  7. DNMT3A and TET1 regulate the epigenome and gene expression at specific targets via their functional interplay.

  8. individual pain vulnerability may be inherent mostly in the emotional/affective component of chronic pain and remain consistent in different aspects of negative emotion, in which adaptive changes in the function of DNA methyltransferase 3a for DNA methylation in central amygdala may play an important role.

  9. Taken together, these data demonstrate that adipose Dnmt3a is a novel epigenetic mediator of insulin resistance in vitro and in vivo.

  10. The aim of the present study is to investigate spatial and temporal expression levels and subcellular localizations of the DNMT1, DNMT3A, and DNMT3B proteins in the mouse germinal vesicle (GV) and metaphase II (MII) oocytes, and early embryos from 1-cell to blastocyst stages.

  11. our Dnmt3a R878H mice have shown that leukemic cells have altered gene expression and epigenetic regulatory patterns contributing to the growth/survival advantage over WT mice.The present study found that the DNMT3A mutation contributed to hypomethylation in the gene body region of mTOR in Dnmt3aR878H/WT mice.

  12. Knockdown of DNMT3A or DNMT1 protected neurons against mutant Htt-induced toxicity, together demonstrating a requirement for DNMTs in mutant Htt-triggered neuronal death and suggesting a neurodegenerative mechanism based on DNA methylation-mediated transcriptional repression.

  13. Data demonstrate that DNMT3A and DNA methylation are key modulators of mast cell responsiveness to acute and chronic stimulation.

  14. These data suggest that DNMT3a is required for nerve injury-induced and MBD1-mediated epigenetic silencing of the MOR and KOR in the injured DRG. DNMT3a inhibition may serve as a promising adjuvant therapy for opioid use in neuropathic pain management.

  15. Data show that conditional deletion of Dnmt3a and simultaneous "knock in" of Flt3ITD/+, cooperate to drive leukemia development at a faster rate than Dnmt3a loss alone.

  16. Deletion of DNMT3a in postnatal forebrain neurons does no alter affective behavior.

  17. Altogether, the authors demonstrate that Dnmt3a and Dnmt3b protect the epidermis from tumorigenesis and that squamous carcinomas are sensitive to inhibition of PPAR-gamma.

  18. Upon lysolecithin injection in the spinal cord of transgenic mice, study detected defective oligodendrocyte progenitor cells differentiation and inefficient remyelination in the DNA methyltransferase 3a null and DNA methyltransferase 1/DNA methyltransferase 3a null mice.

  19. This is attributed in part to ineffective repression of Tcf1 expression in knockout T cells, as DNMT3a localizes to the Tcf7 promoter and catalyzes its de novo methylation in early effector WT CD8(+) T cells. These data identify DNMT3a as a crucial regulator of CD8(+) early effector cell differentiation and effector versus memory fate decisions.

  20. Compared the activity of individual DNMT3A isoforms in embryonic stem and neuronal progenitor cells and report that these isoforms differ in their genomic binding and DNA methylation activity at regulatory sites. We identify that the longer isoform DNMT3A1 preferentially localizes to the methylated shores of bivalent CpG island promoters in a tissue-specific manner.

DNMT3A profil antigène

Profil protéine

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with DNMT3A

  • DNA methyltransferase 3 alpha (DNMT3A) anticorps
  • DNA methyltransferase 3A (Dnmt3a) anticorps
  • DNA methyltransferase 3 alpha (Dnmt3a) anticorps
  • DNA methyltransferase 3 alpha (dnmt3a) anticorps
  • DNA (cytosine-5-)-methyltransferase 3 alpha b (dnmt3ab) anticorps
  • DNMT3A anticorps
  • dnmt3a1 anticorps
  • DNMT3A2 anticorps
  • dnmt6 anticorps
  • M.HsaIIIA anticorps
  • MmuIIIA anticorps

Protein level used designations for DNMT3A

DNA (cytosine-5)-methyltransferase 3A , DNA cytosine methyltransferase 3 alpha , DNA (cytosine-5-)-methyltransferase 3 alpha , DNA MTase HsaIIIA , DNA cytosine methyltransferase 3A2 , DNA methyltransferase 3A , DNA methyl transferase alpha , DNA-methyltransferase 3a , DNA MTase MmuIIIA , DNA methyltransferase MmuIIIA , LOW QUALITY PROTEIN: DNA (cytosine-5)-methyltransferase 3A , DNA (cytosine-5-)-methyltransferase 6

100037301 Sus scrofa
359716 Bos taurus
739139 Pan troglodytes
694822 Macaca mulatta
100055881 Equus caballus
482996 Canis lupus familiaris
1788 Homo sapiens
421991 Gallus gallus
100030681 Monodelphis domestica
100344715 Oryctolagus cuniculus
100500776 Ovis aries
100510798 Felis catus
100594618 Nomascus leucogenys
13435 Mus musculus
444984 Rattus norvegicus
100529107 Anolis carolinensis
100721625 Cavia porcellus
553189 Danio rerio
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