anti-DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) Anticorps

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. De plus, nous expédions DNMT3A Protéines (6) et DNMT3A Kits (2) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
DNMT3A 1788 Q9Y6K1
DNMT3A 444984 Q1LZ53
DNMT3A 13435 O88508
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Top anti-DNMT3A Anticorps sur anticorps-enligne.fr

Showing 10 out of 278 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Souris Inconjugué ChIP, CyTOF, FACS, ICC, IF, IHC (p), IHC (wm), WB Western blot analysis for Dnmt3a using ABIN266067 at 2 ug/ml against 10 ?g of 293 cell lysate transfected with either mouse Dnmt3a (lane A) or mouse Dnmt3b (lane B). Immuno-staining of Dnmt3a using ABIN266067 at 5 ug/ml dilution on cultured HeLa cells. The nucleic staining is shown in most of the cells. 0.1 mg Connectez-vous pour afficher 7 to 9 Days
$514.63
Détails
Humain Lapin Inconjugué IHC (p), WB Western blot analysis of anti-Dnmt3a Pab (ABIN387881) in T47-D cell lysate. Dnmt3a (Arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. Lysates from thymus tissue after radiation were subjected to WB using antibody against DNMT3a. CT, control animals. FR, animals subjected to fractionated exposure. AC, acutely exposed animals. All sample loading was normalized to protein content. Representative Western blots from three independent experiments are shown. each lane represents a protein extract of a thymus of one animal. (Mol. Cancer Res. 2005 Oct 01.3(10):553-561) 400 μL Connectez-vous pour afficher 10 to 11 Days
$335.50
Détails
Humain Lapin Inconjugué ICC, IF, IHC, IHC (p), WB Immunohistochemistry-Paraffin: DNMT3A Antibody [NBP1-85961] - Staining of human liver cancer tumor cells (nuclear) (52 year old female) Immunohistochemistry-Paraffin: DNMT3A Antibody [NBP1-85961] - Staining of human testis shows nuclear positivity in Leydig cells and cells in seminiferous ducts (46 year old male) 0.1 mL Connectez-vous pour afficher 10 to 13 Days
$491.63
Détails
Humain Lapin Inconjugué WB 100 μg Connectez-vous pour afficher 2 to 3 Days
$275.00
Détails
Boeuf (Vache) Lapin Inconjugué WB Host:  Rabbit  Target Name:  DNMT3A  Sample Type:  Lung Tumor lysates  Antibody Dilution:  1.0ug/ml Host:  Mouse  Target Name:  DNMT3A  Sample Tissue:  Mouse Spleen  Antibody Dilution:  1ug/ml 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Humain Lapin Inconjugué ICC, IF, IHC (p), IP, IHC, WB Western blot analysis using ABIN151733 to detect overexpressed DNMT3A level in HCT-116 cells. Lane 1: 40 ug of nuclear extract from untreated HCT-116 cells. Lane 2: 40 ug of Nuclear extract from HCT-116 cells overexpressing DNMT3A. Immunohistochemistry: Dnmt3a Antibody [ABIN151733] - Dnmt3a antibody was tested in human testis using DAB with hematoxylin counterstain. 0.1 mL Connectez-vous pour afficher 7 to 9 Days
$415.44
Détails
Humain Lapin Inconjugué IF/ICC, IHC, WB Western blot analysis of extracts of various cell lines, using DNMT3A antibody (ABIN5971621). Immunohistochemistry of paraffin-embedded rat lung using DNMT3A Antibody (ABIN5971621) at dilution of 1/100 (40x lens). 100 μL Connectez-vous pour afficher 11 to 16 Days
$426.40
Détails
Humain Souris Inconjugué ChIP, WB DNMT3A mAb tested by Western blot. Detection of DNMT3A by Western blot. The analysis was performed using DNMT3A mAb at a 2 µg/ml dilution and whole-cell extracts from 293 cells that had been transfected with plasmid expressing either mouse DNMT3A (lane A) or DNMT3B (lane B). 100 μg Connectez-vous pour afficher 1 to 2 Days
$495.83
Détails
Humain Souris Inconjugué ELISA, FACS, IHC, WB Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng) Western blot analysis using DNMT3A mAb against human DNMT3A (AA: 46-180) recombinant protein. (Expected MW is 40 kDa) 0.1 mg Connectez-vous pour afficher 8 to 11 Days
$561.00
Détails
Humain Lapin Inconjugué IHC (p), WB Western blot analysis of anti-DNMT3A Antibody (Center D472) (ABIN387882) in Jurkat cell line lysates (35 µg/lane).DNMT3A(arrow) was detected using the purified polyclonal antibody (1:60dilution). Formalin-fixed and paraffin-embedded human kidney tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Connectez-vous pour afficher 10 to 11 Days
$335.50
Détails

anti-DNMT3A Anticorps mieux référencés

  1. Human Monoclonal DNMT3A Primary Antibody pour ChIP, CyTOF - ABIN266067 : Chen, Ueda, Xie, Li: A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation. dans The Journal of biological chemistry 2002 (PubMed)
    Show all 84 Pubmed References

  2. Human Polyclonal DNMT3A Primary Antibody pour ICC, IF - ABIN151733 : Robert, Morin, Beaulieu, Gauthier, Chute, Barsalou, MacLeod: DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells. dans Nature genetics 2003 (PubMed)
    Show all 11 Pubmed References

  3. Human Polyclonal DNMT3A Primary Antibody pour IHC (p), WB - ABIN387881 : Xie, Wang, Okano, Nogami, Li, He, Okumura, Li: Cloning, expression and chromosome locations of the human DNMT3 gene family. dans Gene 1999 (PubMed)
    Show all 12 Pubmed References

  4. Human Monoclonal DNMT3A Primary Antibody pour ChIP, WB - ABIN2668262 : Karius, Schnekenburger, Ghelfi, Walter, Dicato, Diederich: Reversible epigenetic fingerprint-mediated glutathione-S-transferase P1 gene silencing in human leukemia cell lines. dans Biochemical pharmacology 2011 (PubMed)
    Show all 3 Pubmed References

  5. Mouse (Murine) Polyclonal DNMT3A Primary Antibody pour IHC, WB - ABIN2668264 : Tognini, Napoli, Tola, Silingardi, Della Ragione, DEsposito, Pizzorusso: Experience-dependent DNA methylation regulates plasticity in the developing visual cortex. dans Nature neuroscience 2015 (PubMed)
    Show all 2 Pubmed References

  6. Human Polyclonal DNMT3A Primary Antibody pour IF (p), IHC (p) - ABIN669336 : Zhao, Hou, Chen, Shao, Zhu, Bu, Gu, Li, Zhang, Du, Fu, Kong, Luo, Long, Li, Deng, Zhao, Cen: Prenatal cocaine exposure impairs cognitive function of progeny via insulin growth factor II epigenetic regulation. dans Neurobiology of disease 2015 (PubMed)
    Show all 2 Pubmed References

  7. Human Polyclonal DNMT3A Primary Antibody pour IHC (p), WB - ABIN387882 : Robertson, Uzvolgyi, Liang, Talmadge, Sumegi, Gonzales, Jones: The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors. dans Nucleic acids research 1999 (PubMed)
    Show all 3 Pubmed References

  8. Human Monoclonal DNMT3A Primary Antibody pour ICC, IF - ABIN2668287 : Felle, Joppien, Németh, Diermeier, Thalhammer, Dobner, Kremmer, Kappler, Längst: The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1. dans Nucleic acids research 2011 (PubMed)

  9. Human Polyclonal DNMT3A Primary Antibody pour WB - ABIN2668283 : Chang, Sun, Kokura, Horton, Fukuda, Espejo, Izumi, Koomen, Bedford, Zhang, Shinkai, Fang, Cheng: MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a. dans Nature communications 2011 (PubMed)

  10. Human Polyclonal DNMT3A Primary Antibody pour WB - ABIN387865 : ODoherty, OShea, Fair: Bovine DNA methylation imprints are established in an oocyte size-specific manner, which are coordinated with the expression of the DNMT3 family proteins. dans Biology of reproduction 2012 (PubMed)

Plus d’anticorps contre DNMT3A partenaires d’interaction

Pig (Porcine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) interaction partners

  1. Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1 (Montrer DNMT1 Anticorps), Dnmt3a, Hdac1 (Montrer HDAC1 Anticorps), Kdm3a (Montrer KDM3A Anticorps) and Uhrf1 (Montrer UHRF1 Anticorps) were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).

Human DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) interaction partners

  1. a feedback loop between miR (Montrer MLXIP Anticorps)-145 and DNMT3A is a potent signature for the Warburg effect in ovarian cancer, promising a potential target for improved anticancer treatment.

  2. In univariable analysis, patients carrying mutations in DNMT3A, U2AF1 (Montrer U2AF1 Anticorps), and EZH2 (Montrer EZH2 Anticorps) had worse overall and relapse-free survival.

  3. Elastic Network Models, information theory, Protein Structure Network, and sequence evolution analysis were used to investigate intrinsic dynamics and allosteric properties of DNMT3A resolved in autoinhibitory and active states. The conformational transition between 2 states shows global motions. The dimer interface has a major role in defining the quaternary structure dynamics and establishing interdomain communication.

  4. HIF1A (Montrer HIF1A Anticorps)-AS2 (Montrer ARSA Anticorps) exerted the oncogenic functions in CRC (Montrer CALR Anticorps) through regulating miR (Montrer MLXIP Anticorps)-129-5p/DNMT3A axis.

  5. we found that DNMT3A was responsible for the down-regulation of miR (Montrer MLXIP Anticorps)-105 in gastric cancer cells

  6. Taken together, these data demonstrate that adipose Dnmt3a is a novel epigenetic mediator of insulin (Montrer INS Anticorps) resistance in vitro and in vivo.

  7. Low frequency of DNMT3A mutations in pediatric T-ALL is in striking contrast to adult T-ALL and renders the necessity for the search of other candidate prognostic markers. Combined Sanger sequencing-HRM approach offers a cost-effective option for genotyping DNMT3A coding sequence, with potential clinical application in other hematological malignancies.

  8. 2.65-angstrom crystal structure of the DNMT3A-DNMT3L (Montrer TRDMT1 Anticorps)-DNA complex in which two DNMT3A monomers simultaneously attack two cytosine-phosphate-guanine (CpG) dinucleotides, with the target sites separated by 14 base pairs within the same DNA duplex; mechanistic basis for DNMT3A-mediated DNA methylation (Montrer HELLS Anticorps) and establishment of its aetiological link to human disease

  9. based on the investigation of previously reported variants in patients with Tatton-Brown-Rahman syndrome , we found overlap in the spectrum of DNMT3A variants observed in this disorder and somatic variants in hematological malignancies

  10. The emodininduced downregulation of UHRF1 (Montrer UHRF1 Anticorps) led to an increase in the level of DNA methyltransferase 3A.

Horse (Equine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) interaction partners

  1. Among 18 genotypes analyzed, we were unable to record any significant differences in 5-methyl-2'-deoxycytidine levels, which suggested that age-related changes in global DNA methylation (Montrer HELLS Anticorps) content are rather a function of time, and not a genetic component.

Cow (Bovine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) interaction partners

  1. The effect of p53 (Montrer TP53 Anticorps) expression on the development of cloned embryos, and its interaction with HDAC1 (Montrer HDAC1 Anticorps) and DNMT3A are reported.

  2. The expression levels of DNMT3a and DNMT3b (Montrer DNMT3B Anticorps) were associated with several beef quality traits.

Mouse (Murine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) interaction partners

  1. individual pain vulnerability may be inherent mostly in the emotional/affective component of chronic pain and remain consistent in different aspects of negative emotion, in which adaptive changes in the function of DNA methyltransferase 3a for DNA methylation (Montrer HELLS Anticorps) in central amygdala may play an important role.

  2. Taken together, these data demonstrate that adipose Dnmt3a is a novel epigenetic mediator of insulin (Montrer INS Anticorps) resistance in vitro and in vivo.

  3. The aim of the present study is to investigate spatial and temporal expression levels and subcellular localizations of the DNMT1 (Montrer DNMT1 Anticorps), DNMT3A, and DNMT3B (Montrer DNMT3B Anticorps) proteins in the mouse germinal vesicle (GV) and metaphase II (MII) oocytes, and early embryos from 1-cell to blastocyst stages.

  4. our Dnmt3a R878H mice have shown that leukemic cells have altered gene expression and epigenetic regulatory patterns contributing to the growth/survival advantage over WT mice.The present study found that the DNMT3A mutation contributed to hypomethylation in the gene body region of mTOR (Montrer FRAP1 Anticorps) in Dnmt3aR878H/WT mice.

  5. Knockdown of DNMT3A or DNMT1 (Montrer DNMT1 Anticorps) protected neurons against mutant Htt (Montrer HTT Anticorps)-induced toxicity, together demonstrating a requirement for DNMTs in mutant Htt (Montrer HTT Anticorps)-triggered neuronal death and suggesting a neurodegenerative mechanism based on DNA methylation (Montrer HELLS Anticorps)-mediated transcriptional repression.

  6. Data demonstrate that DNMT3A and DNA methylation (Montrer HELLS Anticorps) are key modulators of mast cell responsiveness to acute and chronic stimulation.

  7. These data suggest that DNMT3a is required for nerve injury-induced and MBD1 (Montrer DPEP1 Anticorps)-mediated epigenetic silencing of the MOR (Montrer OPRM1 Anticorps) and KOR (Montrer OPRK1 Anticorps) in the injured DRG. DNMT3a inhibition may serve as a promising adjuvant therapy for opioid use in neuropathic pain management.

  8. Data show that conditional deletion of Dnmt3a and simultaneous "knock in" of Flt3ITD/+, cooperate to drive leukemia development at a faster rate than Dnmt3a loss alone.

  9. Deletion of DNMT3a in postnatal forebrain neurons does no alter affective behavior.

  10. Altogether, the authors demonstrate that Dnmt3a and Dnmt3b (Montrer DNMT3B Anticorps) protect the epidermis from tumorigenesis and that squamous carcinomas are sensitive to inhibition of PPAR-gamma (Montrer PPARG Anticorps).

DNMT3A profil antigène

Profil protéine

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with DNMT3A

  • DNA methyltransferase 3 alpha (DNMT3A) anticorps
  • DNA methyltransferase 3 alpha (dnmt3a) anticorps
  • DNA methyltransferase 3 alpha (Dnmt3a) anticorps
  • DNA methyltransferase 3A (Dnmt3a) anticorps
  • DNMT3A anticorps
  • DNMT3A2 anticorps
  • M.HsaIIIA anticorps
  • MmuIIIA anticorps

Protein level used designations for DNMT3A

DNA (cytosine-5-)-methyltransferase 3 alpha , DNA cytosine methyltransferase 3 alpha , DNA (cytosine-5)-methyltransferase 3A , DNA methyl transferase alpha , DNA methyltransferase 3A , DNA MTase HsaIIIA , DNA cytosine methyltransferase 3A2 , DNA-methyltransferase 3a , DNA MTase MmuIIIA , DNA methyltransferase MmuIIIA

GENE ID SPECIES
482996 Canis lupus familiaris
694822 Macaca mulatta
739139 Pan troglodytes
100037301 Sus scrofa
100030681 Monodelphis domestica
100344715 Oryctolagus cuniculus
100500776 Ovis aries
100594618 Nomascus leucogenys
100529107 Anolis carolinensis
1788 Homo sapiens
421991 Gallus gallus
100510798 Felis catus
100055881 Equus caballus
359716 Bos taurus
444984 Rattus norvegicus
13435 Mus musculus
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