anti-Flavin Containing Monooxygenase 1 (FMO1) Anticorps

Mouse (Murine) Flavin Containing Monooxygenase 1 (FMO1) interaction partners

1. Data indicate that in contrast to FMO2 and FMO4, FMO1 is highly expressed in metabolic tissues, including liver, kidney, white adipose tissue (WAT) and brown adipose tissue (BAT).

2. Fmo1, 2, 3, 4 and 5 exhibit distinct cell-, tissue-, sex- and developmental stage-specific patterns of expression.

3. The functional activity of Fmo1 was determined.

4. Deletion of the mouse Fmo1 gene results in enhanced pharmacological behavioral responses to imipramine.

Human Flavin Containing Monooxygenase 1 (FMO1) interaction partners

1. Differential gene expression by SFRP2(+), FMO1(+), and COL11A1(+) fibroblasts suggests roles in matrix deposition, inflammatory cell retention, and connective tissue cell differentiation, respectively.

2. Report developmental regulation of hepatic FMO1 expression.

3. Study tested the genetic effects of three FMOs genes (FMO1, FMO3, and FMO6P) on nicotine dependence by performing targeted sequencing on 2,852 nicotine-dependent and nondependent smokers; identified significant association signals for gene FMO1 and FMO6P

4. data support the role of FMO3 in the N-oxidation of OLA and implicate for the first time the contribution of FMO1 and its functional *6 variant in OLA disposition

5. polymorphisms in FMO1 are significant risk factors in the development of nicotine dependence and that the mechanism may involve variation in nicotine pharmacology.

6. The results of this study suggested that the alteration of FMO gene expression is a consequence of the pathological environment linked to oxidative stress related to mutated SOD1.

7. FMO1 expression is restricted to the fetus; FMO1 suppression occurred within 3 d postpartum in a process tightly coupled to birth, but not gestational age.

8. data from transient expression assays in HepG2 cells suggested this SNP could account for a 2- to 3-fold loss of FMO1 promoter activity.

9. "...in fetal liver, where FMO1 predominates attaining expression levels of (about) 32% of expressed CYP3A4." p. 574 "...recent examples indicate that FMOs play a prominent role in the metabolism ...of important drugs." p. 575

10. FMO1 was found to be down-regulated in human adult brain tissue.

11. Early studies described in this review document that FMO1 is the most abundant FMO enzyme in the human fetal liver, whereas FMO3 is essentially absent.

12. Specific allelic variants of the FMO1 gene might be associated to susceptibility to develop ALS.

13. The resulting data showed that N,N-dimethylamphetamine N-oxidation is mainly mediated by FMO1.