anti-Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 3 (HCN3) Anticorps

Human Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 3 (HCN3) interaction partners

1. Reduced HCN3 expression in aganglionic bowel suggests its potential role in Hirschsprung's disease pathophysiology.

2. KCTD3 is an accessory subunit of native HCN3 complexes

3. Genetic analysis in 48 Sudden unexpected death in epilepsy cases identified six novel and three previously reported nonsynonymous (amino acid changing) variants in HCN1 (Montrer HCN1 Anticorps) , HCN2 (Montrer HCN2 Anticorps), HCN3 and HCN4 (Montrer HCN4 Anticorps).

4. human HCN3 is not modulated by intracellular cAMP, in contrast to other HCN subtypes

Mouse (Murine) Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 3 (HCN3) interaction partners

1. This study demonstrated that Increased expression of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in reactive astrocytes following ischemia.

2. KCTD3 is an accessory subunit of native HCN3 complexes

3. HCN3 contributes to the ventricular action potential waveform in the murine heart.

4. functional expression of HCN3 channels in thalamic intergeniculate leaflet neurons is crucial for intrinsic excitability and rhythmic burst firing

5. Although HCN channel function was greatly reduced in MitoPark DA neurons, mRNA levels for the isoforms most prominently expressed in DA-rich midbrain areas (HCN-3 (Montrer CNGA3 Anticorps) and HCN-1 (Montrer CNGA1 Anticorps)) were similar to those of the control mice.

6. GLI3 (Montrer GLI3 Anticorps) and Hh signaling controls Kit and Hcn3 expression and ureter peristalsis

7. the precise contribution of HCN4 to sinus node function still is unresolved, and in particular the role of HCN4 in human autonomic heart rate response has yet to be established.

8. The expression pattern of HCN isoforms in the olfactory bulb of mice, is described.

9. the distinct expression pattern in conjunction with the unusual biophysical properties implies that HCN3 may play an unique role in the body

10. Current through HCN2 (Montrer HCN2 Anticorps) and HCN3 channels confers regular and faster rhythmicity to mouse embryonic stem cells, which mirrors the developing embryonic mouse heart, and contributes to modulation of rhythmicity by autonomic stimulation.