anti-IKAROS Family Zinc Finger 3 (Aiolos) (IKZF3) Anticorps

Human IKAROS Family Zinc Finger 3 (Aiolos) (IKZF3) interaction partners

1. Aiolos promotes the binding of Blimp-1 (Montrer PRDM1 Anticorps) to target genes and thereby enhances Blimp-1 (Montrer PRDM1 Anticorps)-dependent transcriptional repression.

2. IKZF1 (Montrer IKZF1 Anticorps) and IKZF3 expressions were associated with longer median progression free survival and overall survival in multiple myeloma patients

3. Inhibition of B cell plasmablast differentiation by reduction of Aiolos and Ikaros (Montrer IKZF1 Anticorps) may have utility in the treatment of systemic lupus erythematosus , where elevated levels of BAFF (Montrer TNFSF13B Anticorps) and Aiolos may prime CD27 (Montrer CD27 Anticorps)(+) memory and double negative memory-like B cells to become Ab-producing plasmablasts in the presence of BAFF (Montrer TNFSF13B Anticorps) and proinflammatory cytokines.

4. this study shows that Ikaros (Montrer IKZF1 Anticorps) undergoes a transient increase in protein levels at the transitional single-positive CD8 (Montrer CD8A Anticorps)+ developmental stage before diverging in their expression patterns at later stages

5. Our data indicate a possible regulatory role for the multiple sclerosis-associated IKZF3 and IQGAP1 (Montrer IQGAP1 Anticorps) variants.

6. results indicate that overexpression of Aiolos may contribute to pathogenesis of SLE and RA

7. Aiolos improved the survival of Nalm6 cells via PTEN and Aktdependent processes.

8. NFKB1 (Montrer NFKB1 Anticorps), CD27 (Montrer CD27 Anticorps), LAG3 (Montrer LAG3 Anticorps) and IKZF3 are new susceptibility genes for psoriasis.

9. lentivirus-mediated AIOLOS overexpression in Jurkat cells induced cell apoptosis, arrested the cell cycle at the G0/G1 phase, and synergistically increased the sensitivity of Jurkat cells to etoposide by inhibiting NF-kappaB (Montrer NFKB1 Anticorps) activity.

10. The allele T of rs10852936 surrounding the IKZF3-ZPBP2 (Montrer ZPBP2 Anticorps) locus confers risk for early-onset psoriasis.

Mouse (Murine) IKAROS Family Zinc Finger 3 (Aiolos) (IKZF3) interaction partners

1. These data place Aiolos in the emerging gene regulatory network controlling NK-cell maturation and function.

2. study demonstrated that Aiolos silenced the Il2 (Montrer IL2 Anticorps) locus, promoting TH17 differentiation in vitro and in vivo

3. Aiolos and Ikaros (Montrer IKZF1 Anticorps) bind to the c-myc (Montrer MYC Anticorps) promoter in vivo and directly suppress c-myc (Montrer MYC Anticorps) expression in pre-B cells.

4. Normal Aiolos function is necessary to maintain immune homeostasis and suppress the development of systemic autoimmune disease; Aiolos is implicated as a possible candidate gene for systemic lupus erythematosus.

5. A model is proposed for the control of Bcl-xL's anti-apoptotic role in IL-4 (Montrer IL4 Anticorps)-deprived cells via association to the transcription factor Aiolos.

6. Failure to generate high affinity plasma cells in the bone marrow and to sustain serum antibody titers is apparent after both primary and secondary immunization of Aiolos(-)(/)(-) mice with a range of hapten concentrations.

7. A novel role for OBF-1 (Montrer POU2AF1 Anticorps) and Aiolos in controlling the transcription and nuclear organization of genes involved in pre-BCR (Montrer BCR Anticorps) function.