Inositol(myo)-1(or 4)-Monophosphatase 1 Protéines (IMPA1)

IMPA1 encodes an enyzme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol.

afficher tous les protéines Gène GeneID UniProt
Souris IMPA1 IMPA1 55980  
Rat IMPA1 IMPA1 83523 P97697
Humain IMPA1 IMPA1 3612 P29218
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Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
$5,960.83
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
$5,960.83
Détails
Escherichia coli (E. coli) Humain His tag Validation with Western Blot 10 μg Connectez-vous pour afficher 8 to 11 Days
$504.90
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HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher Disponible
$814.00
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Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
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Escherichia coli (E. coli) Humain His tag 100 μg Connectez-vous pour afficher 20 to 21 Days
$437.80
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Levure Mesembryanthemum crystallinum His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,704.17
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Levure Rat His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,724.33
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Levure Boeuf (Vache) His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,724.33
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Levure Sanglier His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,724.33
Détails

Plus protéines pour Inositol(myo)-1(or 4)-Monophosphatase 1 (IMPA1) partenaires d'interaction

Mouse (Murine) Inositol(myo)-1(or 4)-Monophosphatase 1 (IMPA1) interaction partners

  1. IMPase has a role in intracellular myo (Montrer SYNPO2 Protéines)-inositol synthesis in craniofacial development and the maintenance of proper brain function

  2. local synthesis of IMPA1 is required for neurotrophin (Montrer BDNF Protéines)-dependent axon growth; selective regulation of IMPA1 levels in axons may provide a target for the development of new therapeutic strategies for specific neurological and psychiatric diseases

  3. IMPA1 was expressed in round spermatids

  4. Results suggest that calbindin D28k (Montrer CALB1 Protéines) acts as an activity-dependent sensor that targets membrane/cytoskeleton-bound myo (Montrer SYNPO2 Protéines)-inositol monophosphatase in central neurons.

  5. IMPA2 (Montrer IMPA2 Protéines) has a separate function in vivo from that of IMPA1

  6. IMPA1-/- mouse represents a novel model to study inositol homeostasis, and indicates that genetic inactivation of IMPA1 can mimic some actions of lithium

Human Inositol(myo)-1(or 4)-Monophosphatase 1 (IMPA1) interaction partners

  1. Multibody magnesium cofactor and myo (Montrer SYNPO2 Protéines)-inositol substrate molecular recognition in the myo (Montrer SYNPO2 Protéines)-inositol monophosphatase enzyme have been described.

  2. The identification of a novel homozygous duplication of 5 bp in IMPA1, in a large consanguineous family with nine individuals with severe intellectual disability and disruptive behavior.

  3. The current study did not support a substantial role of the upregulation of IMPase in bipolar disorder, although the lithium-insensitivity trait seen in IMPA2 (Montrer IMPA2 Protéines) transgenic mice might represent some aspect relevant to the inositol depletion hypothesis.

  4. IMPA2 (Montrer IMPA2 Protéines) has a separate function in vivo from that of IMPA1

Profil protéine Inositol(myo)-1(or 4)-Monophosphatase 1 (IMPA1)

Profil protéine

This gene encodes an enyzme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13.

Gene names and symbols associated with IMPA1

  • inositol monophosphatase 1 (impa1)
  • inositol(myo)-1(or 4)-monophosphatase 1 (impa1)
  • inositol (myo)-1(or 4)-monophosphatase 1 (Impa1)
  • inositol monophosphatase 1 (Impa1)
  • inositol monophosphatase (impa1)
  • inositol monophosphatase 1 (IMPA1)
  • inositol(myo)-1(or 4)-monophosphatase 1 S homeolog (impa1.S)
  • inositol(myo)-1(or 4)-monophosphatase 1 (IMPA1)
  • 2610002K09Rik Protéine
  • 2900059K10Rik Protéine
  • AI325909 Protéine
  • IMP Protéine
  • impa Protéine
  • zgc:100926 Protéine

Protein level used designations for IMPA1

inositol monophosphatase 1 , Inositol monophosphatase , IMP 1 , IMPase 1 , inositol-1(or 4)-monophosphatase 1 , lithium-sensitive myo-inositol monophosphatase A1 , myo-inositol monophosphatase

GENE ID SPECIES
437018 Danio rerio
100301752 Oncorhynchus mykiss
100380569 Salmo salar
55980 Mus musculus
83523 Rattus norvegicus
397905 Xenopus laevis
3612 Homo sapiens
444552 Xenopus laevis
477925 Canis lupus familiaris
397425 Sus scrofa
281865 Bos taurus
100174641 Pongo abelii
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