Interferon-Induced Transmembrane Protein 1 Protéines (IFITM1)

IFN-induced antiviral protein that mediate cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus, and dengue virus by inhibiting the early step(s) of replication. De plus, nous expédions IFITM1 Anticorps (109) et et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
Rat IFITM1 IFITM1 293618  
IFITM1 8519 P13164
IFITM1 68713 Q9D103
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Top IFITM1 Protéines sur anticorps-enligne.fr

Showing 6 out of 7 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Connectez-vous pour afficher 50 to 55 Days
$7,493.38
Détails
Cellules d'insectes Souris rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Connectez-vous pour afficher 50 to 55 Days
$5,262.31
Détails
Escherichia coli (E. coli) Humain GST tag Interferon-Induced Transmembrane Protein 1 (IFITM1) (AA 1-36) protein (GST tag) 1 mg Connectez-vous pour afficher 60 to 71 Days
$1,842.50
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher Disponible
$547.80
Détails
Wheat germ Humain Inconjugué   10 μg Connectez-vous pour afficher 11 to 12 Days
$654.29
Détails

IFITM1 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , , ,
, ,
Mouse (Murine)

Plus protéines pour Interferon-Induced Transmembrane Protein 1 (IFITM1) partenaires d'interaction

Human Interferon-Induced Transmembrane Protein 1 (IFITM1) interaction partners

  1. Strong ifitm1 Expression in CD4 T Cells in HIV Controllers Is Correlated With Immune Activation

  2. Using a multi-group heat map from GSE9716 analysis of the GEO database, IFITM1 was determined to be a relevant radioresistance gene. Inhibition of IFITM1 in combination with radiotherapy could, indeed, inhibit oral neoplasm cells.

  3. Inactivated viral particle inoculation increased the expression of IFITM1protein at mRNA and protein levels, and mediated the antiviral state in HUVECs.

  4. Identification of three distinct mutations that converted IFITM1 or IFITM3 from inhibitors to enhancers of MERS-CoV or SARS-CoV spike protein-mediated entry revealed key structural motifs or residues determining the biological activities of IFITM proteins.

  5. Epithelial-mesenchymal transition (EMT) signature was dysregulated by both loss and gain of function of IFITM1, which was partially reverted by Caveolin-1 (CAV1).

  6. These results indicate that IFITM1 protein can restrict alphavirus infection by inhibiting viral fusion with cellular membranes.

  7. The transcriptional regulation of IFITM1, 2 and 3 expression.

  8. IFITM1 and IFITM3 inhibit Zika virus infection early in the viral life cycle.

  9. IFITM1 suppression blocks proliferation and invasion of aromatase inhibitor-resistant breast cancer in vivo by JAK/STAT1-mediated induction of p21.

  10. Compared with CD10, IFITM1 has superior performance distinguishing endometrial stroma of adenomyosis from mesenchyma surrounding invasive endometrial adenocarcinoma.

  11. Overexpression of IFITM1 is associated with Oral Squamous Cell Carcinomas.

  12. High expression of IFITM1 is associated with poor prognosis of colorectal cancer.

  13. These findings indicate that overexpression of IFITM1 enhances the aggressive phenotype of triple-negative SUM149 IBC cells and that this effect is dependent on STAT2/BRG1 interaction.

  14. propose that the IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation and demonstrate that the actions of the IFITM proteins are indeed virus and cell-type specific

  15. the importance of the C-terminal region of IFITM1 in modulating the antiviral function through controlling protein subcellular localization.

  16. Suggest that IFITM1 promotes the aggressiveness of colorectal cancer cells via caveolin-1 signaling.

  17. In virus-producing cells, IFITMs coalesce with forming virions and are incorporated into HIV-1 viral particles.

  18. Incorporation of IFITM1, IFITM2 and IFITM3 into HIV-1 virions impair viral fusion and spread.

  19. Host IFITM3,IFITM2 and IFITM1 facilitate morphogenesis of the human cytomegalovirus assembly.

  20. Schizophrenia subjects with higher IFITM mRNA levels in cortical blood vessels have greater disturbances in cortical GABA neurons suggests that these cell-type disturbances might be influenced by a shared upstream insult that involves immune activation.

Mouse (Murine) Interferon-Induced Transmembrane Protein 1 (IFITM1) interaction partners

  1. Age-related onset of obesity corresponds with metabolic dysregulation and altered microglia morphology in mice deficient for Ifitm proteins.

  2. the importance of the C-terminal region of IFITM1 in modulating the antiviral function through controlling protein subcellular localization.

  3. Palmitoylation of IFITM1 regulates protein stability by preventing proteasomal degradation, and modification of the nonconserved cysteine at the IFITM1 C terminus supports an intramembrane topology with implications for anti-influenza A virus activity.

  4. the fact that IFITM1 can function as a negative regulator of cell proliferation, and because the gene maps to chromosome band 11p15.5, previously associated with NSCLC, it is likely that IFITM1 in man has a key role in tumor formation

  5. Fragilis2 regulates epithelialization of the somites and paraxial mesoderm formation.

  6. The antiproliferative action of IFN-gamma requires the induction of IFITM1.

Profil protéine IFITM1

Profil protéine

IFN-induced antiviral protein that mediate cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus, and dengue virus by inhibiting the early step(s) of replication. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53- dependent manner. Implicated in the control of cell growth. Component of a multimeric complex involved in the transduction of antiproliferative and homotypic adhesion signals.

Gene names and symbols associated with IFITM1

  • interferon induced transmembrane protein 1 (Ifitm1)
  • interferon induced transmembrane protein 1 (IFITM1)
  • interferon induced transmembrane protein 1 (9-27) (IFITM1)
  • 9-27 Protéine
  • 1110036C17Rik Protéine
  • CD225 Protéine
  • DSPA2a Protéine
  • IFI17 Protéine
  • LEU13 Protéine
  • Mil-2 Protéine
  • Mil2 Protéine

Protein level used designations for IFITM1

interferon-induced transmembrane protein 1 , interferon induced transmembrane protein 1 (9-27) , interferon induced transmembrane protein 1 , dispanin subfamily A member 2a , interferon-induced protein 17 , interferon-inducible protein 9-27 , leu-13 antigen , fragilis protein 2 , fragilis2 , ifitm-like protein 2 , interferon induced transmembrane protein 2 like , interferon-induced membrane protein Leu-13/9-27 , interferon-induced transmembrane protein 1 (9-27) , interferon-induced transmembrane protein 1 (9-27) isoform 1

GENE ID SPECIES
293618 Rattus norvegicus
100455800 Pongo abelii
100526663 Pan troglodytes
8519 Homo sapiens
68713 Mus musculus
697687 Macaca mulatta
353510 Bos taurus
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