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The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 [PubMed 9136930]\; Gherzi et al., 2004 [PubMed 15175153]).[supplied by OMIM, Apr 2010].. De plus, nous expédions KHSRP Kits (8) et KHSRP Protéines (5) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal KHSRP Primary Antibody pour ICC, IF - ABIN438746
Zhou, Gong, Eischeid, Chen: miR-27b targets KSRP to coordinate TLR4-mediated epithelial defense against Cryptosporidium parvum infection. dans PLoS pathogens 2012
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Human Polyclonal KHSRP Primary Antibody pour ELISA, WB - ABIN563702
Xu, McCarrey, Hecht: A cytoplasmic variant of the KH-type splicing regulatory protein serves as a decay-promoting factor for phosphoglycerate kinase 2 mRNA in murine male germ cells. dans Nucleic acids research 2008
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Cow (Bovine) Polyclonal KHSRP Primary Antibody pour IHC, WB - ABIN2778858
Ahn, Hwang, Liu, Wang, Zhang, Stephenson, Boronina, Cole, Dinkova-Kostova, Talalay, Cole: Electrophilic tuning of the chemoprotective natural product sulforaphane. dans Proceedings of the National Academy of Sciences of the United States of America 2010
The authors find that KHSRP associates with the regulatory domain of RIG-I (Montrer DDX58 Anticorps) to maintain the receptor in an inactive state and attenuate its sensing of viral RNA (vRNA).
we discovered a novel mechanism underlying SUMOylation of KHSRP regulating the production of some special miRNAs.
KSRP decreased EGR3 (Montrer EGR3 Anticorps) mRNA stability in an ARE-independent manner.
TGF-beta (Montrer TGFB1 Anticorps)-induced KHSRP silencing is central in a pathway leading to gene-expression.
mechanistic evidence that KSRP promotes the down-regulation of Spry4 (Montrer SPRY4 Anticorps) by a previously unidentified mechanism, i.e. post-transcriptional mRNA regulation.
The interaction between the KLHL12 (Montrer KLHL12 Anticorps) and the C-terminal domain of KHSRP contributed to KHSRP ubiquitination, leading to downregulation of enterovirus internal ribosome entry sites-mediated translation in infected cells.
The miRNA biogenesis factors, DDX17 (Montrer DDX17 Anticorps) and KHSRP, regulate the protein level of Ago2 (Montrer EIF2C2 Anticorps) in human cells.
Results show that KHSRP protein is highly expressed in osteosarcoma cells and provide evidence for its important roles in regulatory controls of osteosarcoma pathogenesis.
High FBP2 expression is associated with doxorubicin resistance in breast cancer .
Further analyses indicated that KHSRP was involved in miR-26a maturation and inhibited the expression of PTEN in small cell lung cancer cells
Report KSRP/mRNA/microRNA interactions in chromatoid body of spermatids regulating spermatogenesis.
CXCL-2 (Montrer CXCL2 Anticorps) and HMOX-1 (Montrer HMOX1 Anticorps) were upregulated in H. pylori infection after KSRP overexpression. This difference in expression of these genes implicated that KSRP was closely associated with and directly participated in the innate immune response against H. pylori.
IFN-gamma (Montrer IFNG Anticorps) production was increased in spleen cells of KSRP(-/-) mice.
Resveratrol causes a shift from the mesenchymal-specific forms of these factors to the respective epithelial forms and increases the expression of the RNA-binding proteins KHSRP and hnRNPA1 (Montrer HNRNPA1 Anticorps).
KSRP is critical in governing hepatic lipid metabolism through controlling Per2 (Montrer PER2 Anticorps) expression
KSRP modulation of GAP-43 (Montrer GAP43 Anticorps) mRNA stability restricts axonal outgrowth in embryonic hippocampal neurons.
This study reveals the in vivo function of KSRP in controlling brown-like transformation of subcutaneous/inguinal white adipose tissue through post-transcriptional regulation of miR (Montrer MLXIP Anticorps)-150 expression.
This study reveals a novel in vivo function of KSRP in controlling adipose lipolysis through posttranscriptional regulation of miR (Montrer MLXIP Anticorps)-145 expression.
KSRP is required to maintain P19 cells in undifferentiated state and that its inactivation can orient cells towards neural differentiation.
Our results outline a critical role for KSRP in regulating pro-inflammatory mediators and have implications for a wide range of CNS inflammatory and autoimmune diseases.
The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997
KH-type splicing regulatory protein
, KH-type splicing regulatory protein (FUSE binding protein 2)
, FUSE binding protein 2
, far upstream element-binding protein 2
, FUSE-binding protein 2
, KH type-splicing regulatory protein
, MAP2 RNA trans-acting protein 1
, MAP2 RNA trans-acting protein MARTA1
, zipcode-binding protein 2