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The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 [PubMed 9136930]\; Gherzi et al., 2004 [PubMed 15175153]).[supplied by OMIM, Apr 2010].. De plus, nous expédions KHSRP Anticorps (67) et KHSRP Protéines (5) et beaucoup plus de produits pour cette protéine.
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The authors find that KHSRP associates with the regulatory domain of RIG-I (Montrer DDX58 Kits ELISA) to maintain the receptor in an inactive state and attenuate its sensing of viral RNA (vRNA).
we discovered a novel mechanism underlying SUMOylation of KHSRP regulating the production of some special miRNAs.
KSRP decreased EGR3 (Montrer EGR3 Kits ELISA) mRNA stability in an ARE-independent manner.
TGF-beta (Montrer TGFB1 Kits ELISA)-induced KHSRP silencing is central in a pathway leading to gene-expression.
mechanistic evidence that KSRP promotes the down-regulation of Spry4 by a previously unidentified mechanism, i.e. post-transcriptional mRNA regulation.
The interaction between the KLHL12 and the C-terminal domain of KHSRP contributed to KHSRP ubiquitination, leading to downregulation of enterovirus internal ribosome entry sites-mediated translation in infected cells.
The miRNA biogenesis factors, DDX17 (Montrer DDX17 Kits ELISA) and KHSRP, regulate the protein level of Ago2 (Montrer EIF2C2 Kits ELISA) in human cells.
Results show that KHSRP protein is highly expressed in osteosarcoma cells and provide evidence for its important roles in regulatory controls of osteosarcoma pathogenesis.
High FBP2 expression is associated with doxorubicin resistance in breast cancer .
Further analyses indicated that KHSRP was involved in miR-26a maturation and inhibited the expression of PTEN in small cell lung cancer cells
Report KSRP/mRNA/microRNA interactions in chromatoid body of spermatids regulating spermatogenesis.
CXCL-2 (Montrer CXCL2 Kits ELISA) and HMOX-1 (Montrer HMOX1 Kits ELISA) were upregulated in H. pylori infection after KSRP overexpression. This difference in expression of these genes implicated that KSRP was closely associated with and directly participated in the innate immune response against H. pylori.
IFN-gamma (Montrer IFNG Kits ELISA) production was increased in spleen cells of KSRP(-/-) mice.
Resveratrol causes a shift from the mesenchymal-specific forms of these factors to the respective epithelial forms and increases the expression of the RNA-binding proteins KHSRP and hnRNPA1 (Montrer HNRNPA1 Kits ELISA).
KSRP is critical in governing hepatic lipid metabolism through controlling Per2 (Montrer PER2 Kits ELISA) expression
KSRP modulation of GAP-43 (Montrer GAP43 Kits ELISA) mRNA stability restricts axonal outgrowth in embryonic hippocampal neurons.
This study reveals the in vivo function of KSRP in controlling brown-like transformation of subcutaneous/inguinal white adipose tissue through post-transcriptional regulation of miR (Montrer MLXIP Kits ELISA)-150 expression.
This study reveals a novel in vivo function of KSRP in controlling adipose lipolysis through posttranscriptional regulation of miR (Montrer MLXIP Kits ELISA)-145 expression.
KSRP is required to maintain P19 cells in undifferentiated state and that its inactivation can orient cells towards neural differentiation.
Our results outline a critical role for KSRP in regulating pro-inflammatory mediators and have implications for a wide range of CNS inflammatory and autoimmune diseases.
The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997
KH-type splicing regulatory protein
, KH-type splicing regulatory protein (FUSE binding protein 2)
, FUSE binding protein 2
, far upstream element-binding protein 2
, FUSE-binding protein 2
, KH type-splicing regulatory protein
, MAP2 RNA trans-acting protein 1
, MAP2 RNA trans-acting protein MARTA1
, zipcode-binding protein 2