KH-Type Splicing Regulatory Protein (KHSRP) Kits ELISA

Human KH-Type Splicing Regulatory Protein (KHSRP) interaction partners

1. KSRP, miR-129, and RUNX1 participate in a regulatory axis to control the outcome of myeloid differentiation.

2. The authors find that KHSRP associates with the regulatory domain of RIG-I to maintain the receptor in an inactive state and attenuate its sensing of viral RNA (vRNA).

3. we discovered a novel mechanism underlying SUMOylation of KHSRP regulating the production of some special miRNAs.

4. KSRP decreased EGR3 mRNA stability in an ARE-independent manner.

5. TGF-beta-induced KHSRP silencing is central in a pathway leading to gene-expression.

6. mechanistic evidence that KSRP promotes the down-regulation of Spry4 by a previously unidentified mechanism, i.e. post-transcriptional mRNA regulation.

7. The interaction between the KLHL12 and the C-terminal domain of KHSRP contributed to KHSRP ubiquitination, leading to downregulation of enterovirus internal ribosome entry sites-mediated translation in infected cells.

8. The miRNA biogenesis factors, DDX17 and KHSRP, regulate the protein level of Ago2 in human cells.

9. Results show that KHSRP protein is highly expressed in osteosarcoma cells and provide evidence for its important roles in regulatory controls of osteosarcoma pathogenesis.

10. High FBP2 expression is associated with doxorubicin resistance in breast cancer .

11. Further analyses indicated that KHSRP was involved in miR-26a maturation and inhibited the expression of PTEN in small cell lung cancer cells

12. The expression of KSRP in liver epithelial cells controlled by mir-27b.

13. Khsrp as a highly regulated RBP in response to genotoxic stress.

14. Functional analysis of selected regulated proteins revealed that knockdown of HNRPD, PHB2 and UB2V2 can increase HCMV replication, while knockdown of A4 and KSRP resulted in decreased HCMV replication.

15. The ability of KSRP to integrate different levels of gene expression is required for proper immune response. [Review]

16. subcellular localization of KSRP is regulated by competing interactions with DDX1 or 14-3-3

17. KSRP induces enhanced processing of pri- and pre-miR-155 in cystic fibrosis lung epithelial cells.

18. Enterovirus 71 infection cleaved FBP2, which altered its function when its carboxyl terminus was cleaved.

19. Binding of the human KSRP protein to let-7 miRNA precursors positively regulates their processing to mature let-7, thereby contributing to control of cell proliferation, apoptosis and differentiation

20. The role of KSRP in mRNA decay and microRNA precursor maturation.

Mouse (Murine) KH-Type Splicing Regulatory Protein (KHSRP) interaction partners

1. Report KSRP/mRNA/microRNA interactions in chromatoid body of spermatids regulating spermatogenesis.

2. CXCL-2 and HMOX-1 were upregulated in H. pylori infection after KSRP overexpression. This difference in expression of these genes implicated that KSRP was closely associated with and directly participated in the innate immune response against H. pylori.

3. IFN-gamma production was increased in spleen cells of KSRP(-/-) mice.

4. Resveratrol causes a shift from the mesenchymal-specific forms of these factors to the respective epithelial forms and increases the expression of the RNA-binding proteins KHSRP and hnRNPA1.

5. KSRP is critical in governing hepatic lipid metabolism through controlling Per2 expression

6. KSRP modulation of GAP-43 mRNA stability restricts axonal outgrowth in embryonic hippocampal neurons.

7. This study reveals the in vivo function of KSRP in controlling brown-like transformation of subcutaneous/inguinal white adipose tissue through post-transcriptional regulation of miR-150 expression.

8. This study reveals a novel in vivo function of KSRP in controlling adipose lipolysis through posttranscriptional regulation of miR-145 expression.

9. KSRP is required to maintain P19 cells in undifferentiated state and that its inactivation can orient cells towards neural differentiation.

10. Our results outline a critical role for KSRP in regulating pro-inflammatory mediators and have implications for a wide range of CNS inflammatory and autoimmune diseases.

11. We have identified a post-transcriptional regulatory network active during mouse pituitary development in which the expression of the hormone alphaGSU is increased by let7b/c through downregulation of KSRP

12. data suggest that miR-27b targets KSRP and modulates iNOS mRNA stability following C. parvum infection, a process that may be relevant to the regulation of epithelial anti-microbial defense in general

13. PI3K/AKT signaling determines a dynamic switch between distinct KSRP functions favoring skeletal myogenesis.

14. function of KSRP in innate immunity by negatively regulating interferon production

15. Dishevelled-KSRP complex operates in Wnt regulation of beta-catenin, functioning post-transcriptionally upon CTNNB1 mRNA stability.

16. Results uncover an unanticipated role for KSRP in establishing a biochemical link between differentiation-activated p38 signaling and turnover of myogenic mRNAs.

17. A set of transcripts that are targets of KSRP and whose expression is increased by PI3K-AKT activation.

18. KSRP is misregulated in the absence of SMN, and this correlated with increased mRNA stability of its mRNA target, p21(cip1/waf1), in spinal cord of mild spinal muscular atrophy.

19. In addition to the approximately 75-kDa KSRP, a approximately 52-kD KSRP, t-KSRP, is present in the cytoplasm of a subpopulation of germ cells.

20. Both inhibition of miR-155 and KSRP knockdown enhance the LPS-induced expression of select inflammation mediators, and the effect of KSRP knockdown is reverted by mature miR-155