MAP/microtubule Affinity-Regulating Kinase 2 Protéines (MARK2)

MARK2 encodes a member of the Par-1 family of serine/threonine protein kinases. De plus, nous expédions MAP/microtubule Affinity-Regulating Kinase 2 Anticorps (114) et et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
MARK2 2011 Q7KZI7
MARK2 13728 Q05512
MARK2 60328 O08679
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Top MAP/microtubule Affinity-Regulating Kinase 2 Protéines sur anticorps-enligne.fr

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Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,741.67
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,741.67
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher 11 Days
$888.80
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Wheat germ Humain GST tag 2 μg Connectez-vous pour afficher 11 to 12 Days
$230.67
Détails
Escherichia coli (E. coli) Humain His tag Validation with Western Blot 50 μg Connectez-vous pour afficher 11 Days
$291.50
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Levure Rat His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$4,108.50
Détails
Cellules d'insectes Humain GST tag 5 μg Connectez-vous pour afficher 11 to 12 Days
$516.00
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Baculovirus infected Insect Cells Humain GST tag   5 μg Connectez-vous pour afficher 10 to 12 Days
$363.67
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Cellules d'insectes Humain GST tag   10 μg Connectez-vous pour afficher 3 to 4 Days
$310.00
Détails

MARK2 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , , , ,
, ,
Mouse (Murine)

Rat (Rattus)

Plus protéines pour MAP/microtubule Affinity-Regulating Kinase 2 (MARK2) partenaires d'interaction

Human MAP/microtubule Affinity-Regulating Kinase 2 (MARK2) interaction partners

  1. In cell-based assays, Mark2 depletion indeed reduces Dvl gene expression and interrupts neural stem cell (NSCs) growth and differentiation, which are likely to be mediated through a decrease in class IIa HDAC phosphorylation and reduced H3K4ac and H3K27ac occupancies at the Dvl1/2 promoters.

  2. HIV-1 did not stimulate widespread FEZ1 phosphorylation but, instead, bound microtubule (MT) affinity-regulating kinase 2 (MARK2) to stimulate FEZ1 phosphorylation on viral cores.

  3. Low expression of Mark2 is associated with uterine cervical neoplasms.

  4. In this study, through quantitative analysis of the complex formation between CagA and PAR1b, the authors found that several CagA species have acquired elevated PAR1b-binding activity via duplication of the CagA multimerization motifs, while others have lost their PAR1b-binding activity.

  5. In the modeled structure of inactive MARK2, activation segment occludes the enzyme active site and assumes a relatively stable position.

  6. In conclusion, baicalin and DDP were synergistic at inhibiting proliferation and invasion of human lung cancer cells at appropriate dosages and incubation time in the presence or absence of DDP resistance. The attenuation of DDP resistance was associated with downregulation of MARK2 and p-Akt.

  7. MARK2 plays a role in promoting malignant phenotypes of lung cancer.

  8. Phosphorylation of RNF41 by Par-1b regulates basolateral membrane targeting of laminin-111 receptors.

  9. induces asymmetric inheritance of plasma membrane domains via LGN-dependent mitotic spindle orientation in proliferating hepatocytes

  10. Perturbation of PAR1b and SHP2 by CagA underlies the oncogenic potential of CagA.

  11. The MARK2 binds to the N-terminal tail of Tau and selectively phosphorylates three major and five minor serine residues in the repeat domain and C-terminal tail.

  12. Hepatocyte Par1b defines lumen position in concert with the position of the astral microtubule anchoring complex LGN-NuMA to yield the distinct epithelial division phenotypes.

  13. automated image analysis of MT assembly dynamics identified MARK2 as a target regulated downstream of Rac1 that promotes oriented MT growth in the leading edge to mediate directed cell migration.

  14. The scaffolding adaptor GAB1 interacts with two polarity proteins, PAR1 and PAR3.

  15. The results identify MARK2 as an upstream regulator of PINK1 and DeltaN-PINK1 and provide insights into the regulation of mitochondrial trafficking in neurons and neurodegeneration in PD.

  16. Polarity-regulating kinase partitioning-defective 1b (PAR1b) phosphorylates guanine nucleotide exchange factor H1 (GEF-H1) to regulate RhoA-dependent actin cytoskeletal reorganization.

  17. These data suggest that Par1b-phosphorylation regulates turnover of GEF-H1 localization by regulating its interaction with microtubules, which may contribute to cell polarization.

  18. These results reveal that GAKIN/KIF13B is a key intermediate linking Par1b to the regulation of axon formation.

  19. the 8th and 9th spectrin-like repeats (R8 and R9) of utrophin cooperatively form a PAR-1b-interacting domain, and that Ser1258 within R9 is specifically phosphorylated by PAR-1b.

  20. Par1/Emk1 could have a role in the development of chronic allograft nephropathy in kidney allografts

Mouse (Murine) MAP/microtubule Affinity-Regulating Kinase 2 (MARK2) interaction partners

  1. This studies show that loss of Par1b/MARK2 switches microglia from a surveillant to a primed state during development, resulting in an increased neuroinflammatory response to insults

  2. These results indicate that the basal localization of Par-1b in the outer epithelial cells is required for myoepithelial cell compression, and Par-1b is required for myoepithelial differentiation, regardless of its localization.

  3. data suggest ectopic PAR1 expression is not tolerated in mouse platelets and indicate a different approach is required to develop a small animal model for the purpose of any future preclinical testing of PAR antagonists as anti-platelet drugs

  4. a model whereby MARK2 negatively regulates insulin sensitivity in peripheral tissue through inhibition of KSR1

  5. ROCK1/PAR-1b-dependent regulation of basement membrane placement is required for the coordination of tissue polarity and the elaboration of tissue structure in the developing submandibular salivary gland.

  6. PAR1b plays a novel role in the maintenance of mature dendritic spine morphology by regulating microtubule growth and the accumulation of p140Cap in dendritic spines.

  7. Par-1b is a regulator of glucose metabolism and adiposity in the whole animal

  8. Interaction of MARK2 with CaMKI results in a novel, calcium-dependent pathway that plays an important role in neuronal differentiation.

  9. Akt enhances the activity of PAR1 to promote tau hyperphosphorylation at S262/S356, a tau species that is not recognized by the CHIP/Hsp90 complex

  10. Coreduction of MARK2 and DCX resulted in a partial restoration of the normal neuronal migration phenotype in vivo. The kinetic behavior of the centrosomes reflected the different molecular mechanisms activated when either protein was reduced.

Profil protéine MAP/microtubule Affinity-Regulating Kinase 2 (MARK2)

Profil protéine

This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with MARK2

  • microtubule affinity regulating kinase 2 (MARK2)
  • MAP/microtubule affinity regulating kinase 2 (Mark2)
  • microtubule affinity regulating kinase 2 (Mark2)
  • AU024026 Protéine
  • Emk Protéine
  • EMK-1 Protéine
  • EMK1 Protéine
  • mKIAA4207 Protéine
  • Par-1 Protéine
  • Par-1b Protéine
  • Par1b Protéine

Protein level used designations for MARK2

ELKL motif kinase 1 , PAR1 homolog b , Ser/Thr protein kinase PAR-1B , serine/threonine protein kinase EMK , serine/threonine-protein kinase MARK2 , EMK-1 , EMK1 , serine/threonine kinase

GENE ID SPECIES
100049882 Equus caballus
2011 Homo sapiens
13728 Mus musculus
483769 Canis lupus familiaris
535197 Bos taurus
60328 Rattus norvegicus
100737238 Sus scrofa
100731733 Cavia porcellus
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