Membrane Associated Guanylate Kinase, WW and PDZ Domain Containing 3 Protéines (MAGI3)

associates with tyrosine-phosphorylated proteins to link the receptor with its substrate in the plasma membrane [RGD, Feb 2006].. De plus, nous expédions MAGI3 Anticorps (13) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
Rat MAGI3 MAGI3 245903 Q9JK71
MAGI3 260425 Q5TCQ9
MAGI3 99470 Q9EQJ9
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Showing 4 out of 4 products:

Catalogue No. Origin Source Conjugué Images Quantité Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
$13,741.67
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
$13,741.67
Détails
Wheat germ Humain GST tag 10 μg 11 to 12 Days
$414.29
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$932.80
Détails

MAGI3 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , ,
, ,
Mouse (Murine)

Plus protéines pour Membrane Associated Guanylate Kinase, WW and PDZ Domain Containing 3 (MAGI3) partenaires d'interaction

Human Membrane Associated Guanylate Kinase, WW and PDZ Domain Containing 3 (MAGI3) interaction partners

  1. Study shows that MAGI3 undergoes premature polyadenylation (pPA) at the intron immediately downstream of its large internal exon, which is normally highly modified by N(6)-methyladenosine (m(6)A). In breast cancer cells that upregulate MAGI3 (pPA) , m(6)A levels in the large internal exon of MAGI3 are significantly reduced compared to cells that do not express MAGI3 (pPA). MAGI3 (pPA) transcripts are depleted of m(6)A.

  2. Our findings lend support to a genetic basis for modulation of intestinal epithelial barrier in IBD, and we have identified MAGI3 as a new candidate gene for IBD.

  3. The altered mRNA isoform, called MAGI3(pPA), produces a truncated protein that acts in a dominant-negative manner to prevent full-length MAGI3 from interacting with the YAP oncoprotein, thereby relieving YAP inhibition and promoting malignant transformation of human mammary epithelial cells.

  4. Results identify MAGI3 as a novel tumor suppressor and provide insight into the pathogenesis of glioma.

  5. Expression levels of MAGI3 and PTEN were significantly downregulated in gliomas.

  6. MAGI-3 competes with NHERF-2 to negatively regulate LPA2 receptor signaling in colon cancer cells.

  7. Oncogenic human papillomavirus E6 proteins target the MAGI-2 and MAGI-3 proteins for degradation [MAGI-2, MAGI-3]

  8. In epithelial cells, MAGI-3 was localized with ZO-1 and cingulin at tight junctions, whereas in primary cultured astrocytes it was found in E-cadherin-based cell-cell contacts and in focal adhesion sites.

  9. These results demonstrate that MAGI-3 interacts directly with LPA(2) and regulates the ability of LPA(2) to activate Erk and RhoA.

  10. All of the E6 genes from different HPV types displayed similar abilities to mediate the degradation of both p53 and MAGI-3

Mouse (Murine) Membrane Associated Guanylate Kinase, WW and PDZ Domain Containing 3 (MAGI3) interaction partners

  1. MAGI-3 has a role in efficient trafficking of TGFalpha to the cell surface in polarized epithelial cells.

Profil protéine MAGI3

Profil protéine

associates with tyrosine-phosphorylated proteins to link the receptor with its substrate in the plasma membrane

Gene names and symbols associated with MAGI3

  • membrane associated guanylate kinase, WW and PDZ domain containing 3 (Magi3)
  • membrane associated guanylate kinase, WW and PDZ domain containing 3 (MAGI3)
  • 4732496O19Rik Protéine
  • 6530407C02Rik Protéine
  • AA407180 Protéine
  • AI120132 Protéine
  • dJ730K3.2 Protéine
  • MAGI-3 Protéine
  • mKIAA1634 Protéine
  • RP4-730K3.1 Protéine
  • Slipr Protéine

Protein level used designations for MAGI3

MAGI-3 , membrane-associated guanylate kinase inverted 3 , membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 , membrane-associated guanylate kinase-related (MAGI-3) , scaffolding protein SLIPR , scaffolding-like protein , membrane-associated guanylate kinase-related 3

GENE ID SPECIES
245903 Rattus norvegicus
260425 Homo sapiens
99470 Mus musculus
419877 Gallus gallus
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