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associates with tyrosine-phosphorylated proteins to link the receptor with its substrate in the plasma membrane [RGD, Feb 2006].. De plus, nous expédions MAGI3 Anticorps (16) et beaucoup plus de produits pour cette protéine.
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Study shows that MAGI3 undergoes premature polyadenylation (pPA) at the intron immediately downstream of its large internal exon, which is normally highly modified by N(6)-methyladenosine (m(6)A). In breast cancer cells that upregulate MAGI3 (pPA) , m(6)A levels in the large internal exon of MAGI3 are significantly reduced compared to cells that do not express MAGI3 (pPA). MAGI3 (pPA) transcripts are depleted of m(6)A.
Our findings lend support to a genetic basis for modulation of intestinal epithelial barrier in IBD, and we have identified MAGI3 as a new candidate gene for IBD.
The altered mRNA isoform, called MAGI3(pPA), produces a truncated protein that acts in a dominant-negative manner to prevent full-length MAGI3 from interacting with the YAP oncoprotein, thereby relieving YAP inhibition and promoting malignant transformation of human mammary epithelial cells.
Results identify MAGI3 as a novel tumor suppressor and provide insight into the pathogenesis of glioma.
Expression levels of MAGI3 and PTEN were significantly downregulated in gliomas.
MAGI-3 competes with NHERF-2 to negatively regulate LPA2 receptor signaling in colon cancer cells.
Oncogenic human papillomavirus E6 proteins target the MAGI-2 and MAGI-3 proteins for degradation [MAGI-2, MAGI-3]
In epithelial cells, MAGI-3 was localized with ZO-1 and cingulin at tight junctions, whereas in primary cultured astrocytes it was found in E-cadherin-based cell-cell contacts and in focal adhesion sites.
These results demonstrate that MAGI-3 interacts directly with LPA(2) and regulates the ability of LPA(2) to activate Erk and RhoA.
All of the E6 genes from different HPV types displayed similar abilities to mediate the degradation of both p53 and MAGI-3
MAGI-3 has a role in efficient trafficking of TGFalpha to the cell surface in polarized epithelial cells.
associates with tyrosine-phosphorylated proteins to link the receptor with its substrate in the plasma membrane
, membrane-associated guanylate kinase inverted 3
, membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3
, membrane-associated guanylate kinase-related (MAGI-3)
, scaffolding protein SLIPR
, scaffolding-like protein
, membrane-associated guanylate kinase-related 3