NADH Dehydrogenase (Ubiquinone) 1 alpha Subcomplex, 2, 8kDa Protéines (NDUFA2)

The encoded protein is a subunit of the hydrophobic protein fraction of the NADH:ubiquinone oxidoreductase (complex 1), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane, and may be involved in regulating complex I activity or its assembly via assistance in redox processes. De plus, nous expédions NADH Dehydrogenase (Ubiquinone) 1 alpha Subcomplex, 2, 8kDa Anticorps (42) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
Rat NDUFA2 NDUFA2 291660  
NDUFA2 17991 Q9CQ75
NDUFA2 4695 O43678
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Top NADH Dehydrogenase (Ubiquinone) 1 alpha Subcomplex, 2, 8kDa Protéines sur anticorps-enligne.fr

Showing 9 out of 11 products:

Catalogue No. Origin Source Conjugué Images Quantité Livraison Prix Détails
Escherichia coli (E. coli) Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
$5,370.21
Détails
Escherichia coli (E. coli) Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
$5,370.21
Détails
Wheat germ Humain GST tag 10 μg 11 to 12 Days
$340.00
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
Détails
Escherichia coli (E. coli) Humain His tag 50 μg 15 to 19 Days
$646.15
Détails
Levure Boeuf (Vache) His tag   1 mg 60 to 71 Days
$2,168.83
Détails
Levure Cynomolgus His tag   1 mg 60 to 71 Days
$2,168.83
Détails
Levure Orang-Utan His tag   1 mg 60 to 71 Days
$2,181.67
Détails
Levure Pongo pygmaeus His tag   1 mg 60 to 71 Days
$2,181.67
Détails

NDUFA2 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Mouse (Murine)

Human , ,
, ,

Plus protéines pour NADH Dehydrogenase (Ubiquinone) 1 alpha Subcomplex, 2, 8kDa (NDUFA2) partenaires d'interaction

Mouse (Murine) NADH Dehydrogenase (Ubiquinone) 1 alpha Subcomplex, 2, 8kDa (NDUFA2) interaction partners

  1. The authors use green fluorescent-tagged complex I subunits to determine the kinetics of assembly. Tagged human NDUFA2 may incorporate into the holo-complex I enzyme as an assembly intermediate or as free monomers. The authors conclude that nuclear-encoded subunits incorporate into the holo-enzyme in a subunit-specific manner.

  2. The authors determine the NMR structure of the oxidized human NDUFA2 protein, also known as B8, and report that its structure and redox potential is similar to that of thioredoxins. The highly conserved residues on the surface most likely form the protein-protein interaction site of this subunit with the large multimeric complex I.

  3. differentially expressed in the brains of four mice strains; expression pattern follows ethanol preference of the strains [(NADH-ubiquinone oxidoreductase B8 subunit]

Human NADH Dehydrogenase (Ubiquinone) 1 alpha Subcomplex, 2, 8kDa (NDUFA2) interaction partners

  1. Review of a biorepository of patients with unsolved genetic leukoencephalopathies who underwent whole-exome or genome sequencing allowed us to identify a second patient with compound heterozygous mutations in NDUFA2. Only 1 other patient with mutations in NDUFA2 and a different phenotype (Leigh syndrome) has previously been reported. This is the first report of cystic leukoencephalopathy caused by mutations in NDUFA2.

  2. A novel mechanism of lipoteichoic acid (LTA)-induced cytokine induction in human peripheral blood cells involves uptake of LTA and subsequent intracellular recognition driven by Toll-like receptor (TLR)2, TLR6, and CD14.

  3. solution structure shows a thioredoxin fold with highest similarities to the human thioredoxin mutant C73S and thioredoxin 2 from Anabeana sp

Cow (Bovine) NADH Dehydrogenase (Ubiquinone) 1 alpha Subcomplex, 2, 8kDa (NDUFA2) interaction partners

  1. Both the rate of the NADH-OH binding and its affinity to complex I are strongly decreased in the presence of succinate. The effect of succinate is completely reversed by rotenone, antimycin A, and uncoupler.

Profil protéine NADH Dehydrogenase (Ubiquinone) 1 alpha Subcomplex, 2, 8kDa (NDUFA2)

Profil protéine

The encoded protein is a subunit of the hydrophobic protein fraction of the NADH:ubiquinone oxidoreductase (complex 1), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane, and may be involved in regulating complex I activity or its assembly via assistance in redox processes. Mutations in this gene are associated with Leigh syndrome, an early-onset progressive neurodegenerative disorder. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with NDUFA2

  • NADH:ubiquinone oxidoreductase subunit A2 (Ndufa2)
  • NADH:ubiquinone oxidoreductase subunit A2 (NDUFA2)
  • NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (Ndufa2)
  • NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa (Ndufa2)
  • NADH:ubiquinone oxidoreductase subunit A2 (ndufa2)
  • NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2 (Ndufa2)
  • AV000592 Protéine
  • B8 Protéine
  • C1-B8 Protéine
  • CD14 Protéine
  • CI-B8 Protéine
  • CIB8 Protéine
  • NDUFA2 Protéine

Protein level used designations for NDUFA2

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 , NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa , NADH-ubiquinone oxidoreductase B8 subunit , OXPHOS complex I B8 subunit , complex I-B8 , NADH-ubiquinone oxidoreductase subunit CI-B8 , complex I B8 subunit , NADH-ubiquinone oxidoreductase complex , CI-B8

GENE ID SPECIES
291660 Rattus norvegicus
462119 Pan troglodytes
478032 Canis lupus familiaris
693085 Bombyx mori
768860 Gallus gallus
100117608 Nasonia vitripennis
100124807 Xenopus (Silurana) tropicalis
17991 Mus musculus
4695 Homo sapiens
327698 Bos taurus
100173647 Pongo abelii
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