Oxysterol Binding Protein-Like 1A Protéines (OSBPL1A)

OSBPL1A encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. De plus, nous expédions Oxysterol Binding Protein-Like 1A Anticorps (69) et et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
OSBPL1A 114876 Q9BXW6
OSBPL1A 64291 Q91XL9
Rat OSBPL1A OSBPL1A 259221 Q8K4M9
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Top Oxysterol Binding Protein-Like 1A Protéines sur anticorps-enligne.fr

Showing 4 out of 5 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,741.67
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Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,741.67
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Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
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HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher 11 Days
$932.80
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OSBPL1A Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , ,
, ,
Mouse (Murine)

Plus protéines pour Oxysterol Binding Protein-Like 1A (OSBPL1A) partenaires d'interaction

Human Oxysterol Binding Protein-Like 1A (OSBPL1A) interaction partners

  1. ORP1 is a unique sensor of lysosomal phosphatidylinosito-bisphosphates, and that PI(4,5)P2/PI(3,4)P2 allosterically regulates cholesterol transport by ORP1.

  2. structural and biochemical investigation of the Rab7-ORP1L interaction

  3. ORP1L, via its liganding by lipids and the formation of contacts between autophagic vacuoles and the endoplasmic reticulum, governs the last steps in autophagy that lead to the lysosomal degradation of cytosolic material.

  4. This study validated that rs3746444 polymorphism influenced the expression of miR499a, its target gene, osbpl1a, and thereby associated with the HDL level, which makes it a potential factor involved in the mechanism of atherosclerosis.

  5. ORP1L-dependent membrane contacts between late endosomes/lysosomes and the endoplasmic reticulum coordinate cholesterol transfer with the retrograde movement of endo-lysosomal vesicles.

  6. a familial loss-of-function mutation in OSBPL1A affects the first step of the reverse cholesterol transport process and associates with a low HDL-C phenotype

  7. These data suggest that ORP1L is specifically recruited by the bacteria to the Coxiella parasitophorous vacuole, where it influences parasitophorous vacuole membrane dynamics and interactions with the endoplasmic reticulum.

  8. ORP1L-VAP complexes also support transport of LDL-derived cholesterol from endosomes to the endoplasmic reticulum when ORP1L was bound to human adenovirus RIDalpha. RIDalpha-induced lipid trafficking also attenuated proinflammatory signaling by Toll-like receptor 4, which has a central role in adenovirus pathogenesis and is known to be tightly regulated by cholesterol-rich "lipid rafts."

  9. Data suggest RIDalpha as a model system for understanding physiological egress routes that use ORP1L to activate endosome-to-endoplasmic reticulum (ER) feedback responses involved in lipid droplets (LDs)formation.

  10. ORP1S is a cytoplasmic sterol sensor, which transports sterols to the nucleus and promotes LXR regulated trans-activation of apoE.

  11. The study shows that OSBPL1A binds several oxysterols and cholesterol, and characterize a mutant, OSBPL1A Delta560-563, defective in oxysterol binding.

  12. Results suggest that the two forms of oxysterol binding protein-related protein-1 (ORP1) are functionally distinct and that ORP1L is involved in control of cellular lipid metabolism

  13. binds to Rab7, modifies its functional cycle, and can interfere with lysosome organization and endocytic membrane trafficking.

  14. OSBPL1A was preferentially expressed from the maternal allele

  15. Results describe how ORP1L contacts VAP to control Rab7-RILP-p150 Glued and late endosome positioning.

Mouse (Murine) Oxysterol Binding Protein-Like 1A (OSBPL1A) interaction partners

  1. Osbpl1a silencing in macrophage foam cells enhances endosome motility and results in inhibition of [(3)H]cholesterol efflux to apolipoprotein A-I.

  2. OSBP regulates hepatic TG metabolism and suggest the involvement of OSBP in the insulin signaling pathways that control hepatic lipogenesis.

Profil protéine Oxysterol Binding Protein-Like 1A (OSBPL1A)

Profil protéine

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. Transcript variants derived from alternative promoter usage and/or alternative splicing exist\; they encode different isoforms.

Gene names and symbols associated with OSBPL1A

  • oxysterol binding protein like 1A (OSBPL1A)
  • oxysterol binding protein-like 1A (Osbpl1a)
  • oxysterol binding protein-like 1A (osbpl1a)
  • oxysterol binding protein-like 1A (OSBPL1A)
  • oxysterol-binding protein-related protein 1 (Tsp_09273)
  • oxysterol-binding protein-related protein 1 (Tsp_03387)
  • oxysterol binding protein like 1A L homeolog (osbpl1a.L)
  • oxysterol binding protein like 1A (osbpl1a)
  • oxysterol binding protein like 1A (Osbpl1a)
  • DKFZp459N1538 Protéine
  • G430090F17Rik Protéine
  • Gm753 Protéine
  • ORP-1 Protéine
  • ORP1 Protéine
  • Osbpl1b Protéine
  • si:dkey-121a11.8 Protéine

Protein level used designations for OSBPL1A

OSBP-related protein 1 , oxysterol binding protein-like 1B , oxysterol-binding protein-related protein 1 , oxysterol-binding protein-related protein 1 variant 1 , oxysterol-binding protein-related protein 1 variant 2 , ORP-1 , oxysterol-binding protein-like 1A , oxysterol binding protein-like 1A , oxysterol binding protein-like protein 1A , oxysterol-binding protein-related protein 1-like

GENE ID SPECIES
114876 Homo sapiens
64291 Mus musculus
259221 Rattus norvegicus
565503 Danio rerio
100174299 Pongo abelii
10905070 Trichinella spiralis
10909128 Trichinella spiralis
421079 Gallus gallus
468500 Pan troglodytes
480761 Canis lupus familiaris
495678 Xenopus laevis
616555 Bos taurus
677867 Macaca mulatta
100010444 Monodelphis domestica
100127588 Xenopus (Silurana) tropicalis
100356707 Oryctolagus cuniculus
100403124 Callithrix jacchus
100480218 Ailuropoda melanoleuca
100511459 Sus scrofa
100540838 Meleagris gallopavo
100557357 Anolis carolinensis
100600026 Nomascus leucogenys
100717854 Cavia porcellus
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