anti-Potassium Channel, Subfamily K, Member 2 (KCNK2) Anticorps

KCNK2 encodes one of the members of the two-pore-domain background potassium channel protein family. De plus, nous expédions KCNK2 Protéines (4) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
KCNK2 3776 O95069
KCNK2 16526 P97438
KCNK2 170899  
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Showing 10 out of 38 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Lapin Inconjugué WB Western blot analysis of Trek-1 in Jurkat cell lysantes (Lane 1, 2). 3T3 cell Lysante (Lane 3), and rat kidney tissue lysante (Lane 4). 100 μg Connectez-vous pour afficher 2 to 3 Days
$245.00
Détails
Boeuf (Vache) Lapin Inconjugué WB Detection of TREK 1 in human brain membrane lysate using ABIN188929. 0.1 mL Connectez-vous pour afficher 7 to 9 Days
$444.19
Détails
Humain Lapin Inconjugué IHC, WB IHC on paraffin sections of rat DRG tissue using Rabbit antibody to KCNK2: .HIER: 1 mM EDTA, pH 8 for 20 min using Thermo PT Module.Blocking: 0.2% LFDM in TBST filtered thru 0.2 µm.Detection was done using Novolink HRP polymer from Leica following manufacturer's instructions.Primary antibody: dilution 1: 1000, incubated 30 min at RT (using Autostainer).Sections were counterstained with Harris Hematoxylin. 100 μL Connectez-vous pour afficher 7 to 8 Days
$454.67
Détails
Souris Lapin Inconjugué ELISA, WB   100 μg Connectez-vous pour afficher 7 to 9 Days
$419.83
Détails
Humain Lapin Inconjugué WB Detection of KCNK2 in human brain membrane lysate using KCNK2 polyclonal antibody . 100 μL Connectez-vous pour afficher 11 to 12 Days
$460.00
Détails
Humain Lapin Inconjugué ELISA, WB   100 μg Connectez-vous pour afficher 7 to 9 Days
$793.83
Détails
Humain Lapin Inconjugué WB   100 μL Connectez-vous pour afficher 7 to 9 Days
$859.83
Détails
Humain Lapin Inconjugué WB   200 μL Connectez-vous pour afficher 11 to 16 Days
$1,147.14
Détails
Humain Lapin Inconjugué WB   100 μL Connectez-vous pour afficher 11 to 16 Days
$638.00
Détails
Boeuf (Vache) Lapin DyLight 488 WB   0.1 mL Connectez-vous pour afficher 8 to 11 Days
$556.31
Détails

anti-KCNK2 Anticorps mieux référencés

  1. Cow (Bovine) Polyclonal KCNK2 Primary Antibody pour WB - ABIN188929 : Zhang, Yin, Wang, Li, Wang: Over-expressed human TREK-1 inhibits CHO cell proliferation via inhibiting PKA and p38 MAPK pathways and subsequently inducing G1 arrest. dans Acta pharmacologica Sinica 2016 (PubMed)

Plus d’anticorps contre KCNK2 partenaires d’interaction

Cow (Bovine) Potassium Channel, Subfamily K, Member 2 (KCNK2) interaction partners

  1. ANG II inhibits bTREK-1 K(+) channels by a Ca(2+)-dependent mechanism that does not require the depletion of membrane-associated PIP(2).

  2. Metabolites of cAMP stimulate TREK-1 expression in adrenal cortex cells by activation of a novel cAMP-independent mechanism.

  3. TREK-1 channels may function as sensors that couple the metabolic state of the cell to membrane potential, perhaps through an associated ATP-binding protein

  4. These results identify bTREK-1 K(+) channels as a pivotal control point where ANG II (Montrer AGT Anticorps) receptor activation is transduced to depolarization-dependent Ca(2 (Montrer CA2 Anticorps)+) entry and aldosterone secretion.

  5. Data show that angiotensin II and paracrine factors that act through phospholipase C (Montrer PLC Anticorps) inhibit bTREK-1 in adrenocortical cells through simultaneous activation of separate Ca2 (Montrer CA2 Anticorps)+- and ATP hydrolysis-dependent signaling pathways.

  6. Angiotensin II (ANGII) inhibits adrenocortical cell KCNK2 in an ATP dependent, PLC/PKC independent manner.

  7. These findings demonstrate that, in addition to the well-described PKA-dependent TREK-1 inhibition, ACTH (Montrer POMC Anticorps), NPS (Montrer NPS Anticorps)-ACTH (Montrer POMC Anticorps), forskolin, and 8-pCPT-2'-O-Me-cAMP also inhibit these K(+) channels by a PKA-independent signaling pathway.

Human Potassium Channel, Subfamily K, Member 2 (KCNK2) interaction partners

  1. data reveal a druggable K2P site that stabilizes the C-type gate 'leak mode' and provide direct evidence for K2P selectivity filter gating

  2. decreased TREK-1 expression in the aganglionic and ganglionic bowel observed in Hirschsprung's disease may alter intestinal epithelial barrier function leading to the development of enterocolitis

  3. Atrial TREK-1 expression was reduced in atrial fibrillation patients with concomitant severe heart failure

  4. The authors identified a heterozygous point mutation in the selectivity filter of the stretch-activated K2P potassium channel (Montrer KCNAB2 Anticorps) TREK-1 (KCNK2 or K2P2.1). This mutation introduces abnormal sodium permeability and stretch-activation hypersensitivity to TREK-1.

  5. The M2-glycine hinge controls the macroscopic currents of TREK1 channels.

  6. TREK-1 overexpression suppresses CHO (Montrer COL11A1 Anticorps) cell proliferation by inhibiting the activity of PKA and p38/MAPK (Montrer MAPK14 Anticorps) signaling pathways and subsequently inducing G1 phase cell arrest.

  7. Trek1 expression facilitates the restoration of intestinal epithelial barrier functions in an allergic environment.

  8. presence of TREK-1 variants correlated to reduced TREK-1 activity, suggesting a pathological role for TREK-1 variants in preterm labor

  9. Data suggest that potassium channel protein (Montrer KCNQ5 Anticorps) TREK-1 (TREK-1) might be a biomarker in castration resistance free survival (CRFS) judgment of prostate cancer (PCa (Montrer FLVCR1 Anticorps)), as well as a potential therapeutic target.

  10. During conductance simulation experiments, both TASK-3 (Montrer KCNK9 Anticorps) and TREK-1 channels were able to repolarise the membrane once AP threshold was reached

Mouse (Murine) Potassium Channel, Subfamily K, Member 2 (KCNK2) interaction partners

  1. Data demonstrate that inhibition of TWIK (Montrer KCNK1 Anticorps)-related K(+) channel (Montrer KCNC4 Anticorps)-1 (TREK-1) protects mice from cognitive impairment induced by anesthesia and TREK-1 is a potential therapeutic target against memory impairment induced by volatile anesthetics.

  2. data reveal a druggable K2P site that stabilizes the C-type gate 'leak mode' and provide direct evidence for K2P selectivity filter gating

  3. Hyperoxia treatment of TREK-1/TREK-2 (Montrer KCNK10 Anticorps)/TRAAK (Montrer KCNK4 Anticorps)-deficient mice is associated with a reduction in surfactant proteins

  4. TREK-1 deficiency promoted neurons and oligodendrocytes apoptosis, aggravated demyelination and retarded motor recovery following spinal cord injury.

  5. Formation of TREK-1/TREK-2 (Montrer KCNK10 Anticorps) channels was also demonstrated in native dorsal root ganglion neurons indicating that heterodimerization may provide greater diversity of leak K(+) conductances also in native tissues.

  6. Trek1 expression facilitates the restoration of intestinal epithelial barrier functions in an allergic environment.

  7. Data suggest that porosome-associated proteins SNAP25 (Montrer SNAP25 Anticorps), TREK-1, syntaxin-1A (Montrer STX1A Anticorps), and Gai3 exhibit stability and functionality such that isolated proteins can be reconstituted as insulin (Montrer INS Anticorps)-secreting porosomes in cell membrane of live cells.

  8. Data indicate that arginine vasopressin (AVP (Montrer AVP Anticorps)) and corticotropin-releasing hormone (CRH (Montrer CRH Anticorps)) show additive effects on the suppression of the potassium channel subfamily K member 2 TREK-1 current via protein kinase C (Montrer PKC Anticorps).

  9. TWIK-1 (Montrer KCNK1 Anticorps)/TREK-1 heterodimers mediate astrocytic passive conductance and cannabinoid-induced glutamate (Montrer GRIN1 Anticorps) release from astrocytes.

  10. In TREK1-deficient mice, brain endothelial cells displayed an inflammatory phenotype.

KCNK2 profil antigène

Profil protéine

This gene encodes one of the members of the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers that create a channel that leaks potassium out of the cell to control resting membrane potential. The channel can be opened, however, by certain anesthetics, membrane stretching, intracellular acidosis, and heat. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with KCNK2

  • potassium two pore domain channel subfamily K member 2 (KCNK2) anticorps
  • potassium channel, two pore domain subfamily K, member 2 (kcnk2) anticorps
  • potassium channel, subfamily K, member 2 (Kcnk2) anticorps
  • potassium two pore domain channel subfamily K member 2 (Kcnk2) anticorps
  • A430027H14Rik anticorps
  • AI848635 anticorps
  • hTREK-1c anticorps
  • hTREK-1e anticorps
  • K2p2.1 anticorps
  • KCNK2 anticorps
  • rTREK1d anticorps
  • TPKC1 anticorps
  • TREK anticorps
  • Trek-1 anticorps
  • TREK1 anticorps

Protein level used designations for KCNK2

potassium channel subfamily K member 2 , potassium channel, subfamily K, member 2 , potassium channel subfamily K member 2-like , K2P2.1 potassium channel , TREK-1 K(+) channel subunit , TWIK-related potassium channel 1 , outward rectifying potassium channel protein TREK-1 , potassium inwardly-rectifying channel, subfamily K, member 2 , tandem-pore-domain potassium channel TREK-1 , two pore domain potassium channel TREK-1 , two pore potassium channel TPKC1 , two-pore potassium channel 1 , arachidonic acid sensitive tandem pore domain potassium channel , ion transport membrane protein

GENE ID SPECIES
282590 Bos taurus
457734 Pan troglodytes
490295 Canis lupus familiaris
708705 Macaca mulatta
770954 Gallus gallus
100023531 Monodelphis domestica
100050114 Equus caballus
100356478 Oryctolagus cuniculus
100400002 Callithrix jacchus
100435329 Pongo abelii
100481291 Ailuropoda melanoleuca
100495685 Xenopus (Silurana) tropicalis
100601855 Nomascus leucogenys
3776 Homo sapiens
16526 Mus musculus
170899 Rattus norvegicus
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