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KCNK5 encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains.
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In human aldosterone-producing adrenocortical cancer cell lines, roxithromycin inhibited KCNJ5MUT-induced induction of CYP11B2 (Montrer CYP11B2 Anticorps) (encoding aldosterone synthase (Montrer CYP11B2 Anticorps)) expression and aldosterone production.
HLA-DQB1 (Montrer HLA-DQB1 Anticorps)*06:02 does not seem to be associated with hypoxic ventilatory response or hypercapnic ventilatory response; however there are point wise, uncorrected significant associations between two TASK2/KCNK5 variants (rs2815118 and rs150380866) and hypercapnic ventilatory response
These results therefore provide further structural and functional insights into the possible pathophysiological effects of this missense variant in TASK-2.
Results show that up-regulated KCNK5 in activated human T cells does not play a volume regulatory role, due to decreased Cl- permeability suggesting that the KCNK5 upregulation might play a role in hyperpolarization of the cell membrane leading to increased Ca2 (Montrer CA2 Anticorps)+ influx and proliferation of T cells.
Potassium channel (Montrer KCNAB2 Anticorps) TASK2 drives human NK-cell proliferation and cytolytic function.
Mutant genes (CELA1 (Montrer CELA1 Anticorps), HSPG2 (Montrer HSPG2 Anticorps), and KCNK5) in Balkan endemic nephropathy patients encode proteins involved in basement membrane/extracellular matrix and vascular tone, tightly connected to process of angiogenesis.
The TASK-2 channel lower expression represents a hallmark of aldosterone-producing adenoma causing aldosteronism and is associated with a higher expression of hsa (Montrer CD24 Anticorps)-miR (Montrer MLXIP Anticorps)-23 and hsa (Montrer CD24 Anticorps)-miR (Montrer MLXIP Anticorps)-34.
Potassium channels, in particular K2P channels, are expressed and functional in the apical membrane of airway epithelial cells
Disease activity in rheumatoid arthritis patients correlates strongly with K(2P)5.1 expression levels in CD4 (Montrer CD4 Anticorps)+ T lymphocytes in the peripheral blood
17beta-estradiol induces the expression of KCNK5 via ERalpha (Montrer ESR1 Anticorps)(+) in breast cancer cells, and this channel plays a role in regulating proliferation in these cell lines.
KCNK5 channels are indispensable for the maintenance of hearing. KCNK5 is mainly found in outer sulcus Claudius', Boettcher's and root cells.
The data identify GPR4 (Montrer GPR4 Anticorps) and TASK-2 as distinct, parallel, and essential central mediators of respiratory chemosensitivity.
TASK-2 is upregulated under hypoxia in a HIF-1alpha (Montrer HIF1A Anticorps)-dependent manner in B cells.
The strong physiological impairment of KCNK5 in Ehrlich cells after long-term hypotonic stimulation is predominantly due to down-regulation of the KCNK5 protein synthesis.
data are compatible with the concept that TASK-2 channels are modulated by Gbetagamma subunits of heterotrimeric G protein; propose that this modulation is a novel way in which TASK-2 can be tuned to its physiological functions
alkaline-activated TASK-2 channels contribute to pH sensitivity in retrotrapezoid nucleus neurons
Kv1.3 (Montrer KCNA3 Anticorps)/TASK2 channels appear to be mainly responsible for regulatory volume decrease in murine T-lymphocytes.
a cycle of protonation/deprotonation of pH(o)-sensing arginine 224 side chain gates the TASK-2 channel by electrostatically tuning the conformational stability of its selectivity filter.
The authors report for the first time the expression of TASK-2 in B cells and surmise that the upregulation of TASK-2 by B cell receptor ligation is associated with the apoptosis of immature B cells.
intracellular pH, together with pH(o), is a critical determinant of TASK-2 activity and therefore of its physiological function
This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH and this, in combination with its expression pattern, suggests it may play an important role in renal potassium transport.
potassium channel, subfamily K, member 5
, potassium channel subfamily K member 5-like
, K2P5.1 potassium channel
, TWIK-related acid-sensitive K(+) channel 2
, TWIK-related acid-sensitive K+ channel 2
, acid-sensitive potassium channel protein TASK-2
, potassium channel subfamily K member 5
, potassium channel, subfamily K, member 1 (TASK-2)
, potassium inwardly-rectifying channel, subfamily K, member 5