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PYCR2 belongs to the pyrroline-5-carboxylate reductase family. De plus, nous expédions Pyrroline-5-Carboxylate Reductase Family, Member 2 Protéines (13) et beaucoup plus de produits pour cette protéine.
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PYCR2-related syndrome represents a clinically recognizable condition in which PYCR2 mutations lead to protein dysfunction.
It was found that silence of PYCR2 resulted in the decrease of proliferative ability and activation of AMPK/mTOR-induced autophagy of A375 cells. PYCR2 silencing also activated AMPK/mTOR pathway in another melanoma cell line, CHL-1.
Silencing of both PYCR1 (Montrer PYCR1 Anticorps) and PYCR2 completely abolished anti-oxidation activity of RRM2B (Montrer RRM2B Anticorps), demonstrating a functional collaboration of these metabolic enzymes in response to oxidative stress.
Hypomyelination and the absence of lax (Montrer LAX1 Anticorps) caused by previously reported mutations in the gene encoding PYCR2's isozyme, PYCR1 (Montrer PYCR1 Anticorps), suggesting a unique and indispensable role for PYCR2 in the human CNS during development.
This gene belongs to the pyrroline-5-carboxylate reductase family. The encoded mitochondrial protein catalyzes the conversion of pyrroline-5-carboxylate to proline, which is the last step in proline biosynthesis. Alternatively spliced transcript variants have been described for this gene.
pyrroline-5-carboxylate reductase family, member 2
, pyrroline-5-carboxylate reductase 2
, putative pyrroline-5-carboxylate reductase family member 2 variant 1
, P5C reductase 2
, pyrroline 5-carboxylate reductase isoform
, P5CR 2
, pyrroline-5-carboxylate reductase