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RNF212 encodes a RING finger protein that may function as a ubiquitin ligase.
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Dog (Canine) Polyclonal RNF212 Primary Antibody pour ELISA - ABIN449732
Kong, Thorleifsson, Stefansson, Masson, Helgason, Gudbjartsson, Jonsdottir, Gudjonsson, Sverrisson, Thorlacius, Jonasdottir, Hardarson, Palsson, Frigge, Gulcher, Thorsteinsdottir, Stefansson: Sequence variants in the RNF212 gene associate with genome-wide recombination rate. dans Science (New York, N.Y.) 2008
This paper describes a partial transcript of the human RNF212 gene.
genome search identified sequence variants in the 4p16.3 region correlated with recombination rate in males & females; variants are located in the RNF212 gene, a putative ortholog of ZHP-3 gene essential for recombination & chiasma formation in C elegans
We fine-map three QTL and present strong evidence that genetic variants in REC8 (Montrer REC8 Anticorps) and RNF212 influence genome-wide recombination rate, while genetic variants in PRDM9 (Montrer PRDM9 Anticorps) influence genome-wide hotspot usage.
This gene encodes a RING finger protein that may function as a ubiquitin ligase. The encoded protein may be involved in meiotic recombination. This gene is located within a linkage disequilibrium block and polymorphisms in this gene may influence recombination rates. Alternate splicing results in multiple transcript variants.
probable E3 SUMO-protein ligase RNF212