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Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins.
Showing 10 out of 58 products:
Human Polyclonal SSTR3 Primary Antibody pour ICC, IF - ABIN261626
Arne, Nilsson, Dalmo, Kristiansson, Arvidsson, Forssell-Aronsson, Nilsson, Ahlman: Gastrointestinal stromal tumors (GISTs) express somatostatin receptors and bind radiolabeled somatostatin analogs. dans Acta oncologica (Stockholm, Sweden) 2013
Human Monoclonal SSTR3 Primary Antibody pour IHC (p) - ABIN2476550
Schmid, Lambertini, van Vugt, Barzaghi-Rinaudo, Schäfer, Hillenbrand, Sailer, Kaufmann, Nuciforo: Monoclonal antibodies against the human somatostatin receptor subtypes 1-5: development and immunohistochemical application in neuroendocrine tumors. dans Neuroendocrinology 2012
the C-terminal phosphorylation motif of the human sst3 receptor that regulates its agonist-promoted phosphorylation, beta-arrestin recruitment, and internalization of this clinically relevant receptor, is reported.
Data showed that the distribution of somatostatin (Montrer SST Anticorps) receptor (SSTR) subtypes among the 199 pancreatic neuroendocrine tumors (PNETs) was: SSTR2 (Montrer SSTR2 Anticorps) (54.8%), SSTR1 (Montrer SSTR1 Anticorps) (53.3%), SSTR4 (Montrer SSTR4 Anticorps) (51.8%), SSTR5 (Montrer SSTR5 Anticorps) (33.7%), and SSTR3 (28.6%).
Data indicate that somatostatin (Montrer SST Anticorps) receptor scintigraphy (SRS (Montrer SMS Anticorps)) and immunohistochemical results for somatostatin (Montrer SST Anticorps) and dopamine receptors sstr2 (Montrer SSTR2 Anticorps), sstr3, sstr5 (Montrer SSTR5 Anticorps) and D2R (Montrer DRD2 Anticorps) were compared in neuroendocrine neoplasms tissues.
findings provide new insights in understanding the antiproliferative role of SSTR3 in breast tumor biology.
An immunohistochemical investigation of the expression of somatostatin (Montrer SST Anticorps) receptor subtypes
In conclusions, in CNFAs, high expression of somatostatin (Montrer SST Anticorps) receptors is much less common than that of D2R (Montrer DRD2 Anticorps)
SSTR2A and SSTR3 are more likely to be expressed in SDH (Montrer SARDH Anticorps)-deficient pheochromocytomas/paragangliomas compared with tumors demonstrating normal SDHB (Montrer SDHB Anticorps) staining pattern.
constitutive SSTR3 activity mediates transcriptional repression of GH.
High SSTR3 expression is associated with gallbladder cancer.
Determination of the expression of SSTR3 in an attempt to establish correlations and/or associations with clinical characteristics of patients with nonfunctioning pituitary adenomas.
results implicate beta-arrestin in the modulation of Sstr3 ciliary localization and further suggest a role for beta-arrestin in the mediation of Sstr3 ciliary signaling.
The expression and localization of the three receptors (SSTR3-SSTR5 (Montrer SSTR5 Anticorps)) in wild-type (WT), single-knockout (SSTR1 (Montrer SSTR1 Anticorps) KO) and double-knockout SSTR1 (Montrer SSTR1 Anticorps)/SSTR2 (Montrer SSTR2 Anticorps) (DKO) mice, are reported.
Both Sstr3 (and SStr2 (Montrer SSTR2 Anticorps)) receptors are required for the anticonvulsant effects mediated by cortistatin-14 (Montrer CORT Anticorps).
SSTR3 immunoreactivity increases in ApoD (Montrer APOD Anticorps)(-/-) mice in all major nuclei of hypothalamus, median eminence, and ependymal cells of third ventricle.
Mchr1 (Montrer MCHR1 Anticorps) and Sstr3 are expressed and colocalized within cilia in multiple mouse brain regions, and they form heteromers.
this novel finding that Rab21 (Montrer RAB21 Anticorps) regulates SSTR3 trafficking suggests that Rab21 (Montrer RAB21 Anticorps) may play a role in trafficking of other GPCRs.
somatostatin receptor 3 expression was restricted to the plasma membrane of cilia in insulin- and growth hormone-secreting cells of the mouse, differing from previously reported immunohistochemical localization in cell bodies
Receptor coupling to adenylyl cyclase is disrupted upon Sstr3 C-tail deletions.
From the data of this study shown that somatostatin receptor 3 is critical for object recognition memory.
The effect of sst2 receptor knockout on sst3 receptor mRNA localization and binding sites throughout the brain has been determined.
Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR3 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in brain and pancreatic islets. SSTR3 is functionally coupled to adenylyl cyclase.
somatostatin receptor type 3
, somatostatin receptor 3
, somatostatin receptor 28
, somatostatin receptor subtype 3