TEL2, Telomere Maintenance 2, Homolog (S. Cerevisiae) Protéines (TELO2)

TELO2 encodes a protein that functions as an S-phase checkpoint protein in the cell cycle. De plus, nous expédions TEL2, Telomere Maintenance 2, Homolog (S. Cerevisiae) Anticorps (34) et et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
Rat TELO2 TELO2 302986  
TELO2 71718 Q9DC40
TELO2 9894 Q9Y4R8
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Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,984.89
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Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,984.89
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HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher Disponible
$814.00
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TELO2 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Mouse (Murine)

Human ,
,

Plus protéines pour TEL2, Telomere Maintenance 2, Homolog (S. Cerevisiae) (TELO2) partenaires d'interaction

Mouse (Murine) TEL2, Telomere Maintenance 2, Homolog (S. Cerevisiae) (TELO2) interaction partners

  1. IP7, formed by IP6K2 (Montrer IP6K2 Protéines), binds CK2 (Montrer CSNK2A1 Protéines) to enhance its phosphorylation of the Tti1 (Montrer TTI1 Protéines)/Tel2 complex, thereby stabilizing DNA-PKcs (Montrer PRKDC Protéines) and ATM (Montrer ATM Protéines). This process stimulates p53 (Montrer TP53 Protéines) phosphorylation at serine 15 to activate the cell death program.

  2. The CK2 phospho-dependent interaction between TEL2 and the R2TP complex affects phosphatidylinositol 3-kinase-related kinase functions and is essential for mTOR and SMG1 stability in vivo.

  3. Identify Tel2 as a highly conserved regulator of the stability of PI3K-related protein kinases.

Human TEL2, Telomere Maintenance 2, Homolog (S. Cerevisiae) (TELO2) interaction partners

  1. Taken together, human high-grade gliomas increase TELO2 mRNA expression, and overexpression of TELO2 mRNA expression correlates with shorter survival outcome, supporting that TELO2 is an oncotarget in human gliomas.

  2. TELO2 missense variants result in loss of function, perturb TTT complex stability, and cause an autosomal-recessive syndromic form of Intellectual Disability Disorder.

  3. IP7, formed by IP6K2 (Montrer IP6K2 Protéines), binds CK2 (Montrer CSNK2A1 Protéines) to enhance its phosphorylation of the Tti1 (Montrer TTI1 Protéines)/Tel2 complex, thereby stabilizing DNA-PKcs (Montrer PRKDC Protéines) and ATM (Montrer ATM Protéines). This process stimulates p53 (Montrer TP53 Protéines) phosphorylation at serine 15 to activate the cell death program.

  4. The SAM (Montrer TTN Protéines) domain of human TEL2 can inhibit the transcriptional activities of ETS1 (Montrer ETS1 Protéines)/2 and TEL1 (Montrer ATM Protéines).

  5. Data show that that knockdown of either Tti1 (Montrer TTI1 Protéines) or Tel2 causes disassembly of mTORC1 and mTORC2 (Montrer CRTC2 Protéines).

  6. The CK2 phospho-dependent interaction between TEL2 and the R2TP complex affects phosphatidylinositol 3-kinase-related kinase functions and is essential for mTOR and SMG1 stability in vivo.

  7. TTI1 (Montrer TTI1 Protéines) and TTI2 (Montrer TTI2 Protéines) exist in multiple complexes, including a 2-MDa complex with TEL2 (telomere maintenance 2), called the Triple T complex, and phosphoinositide-3-kinase-related protein (Montrer MYLK Protéines) kinases (PIKKs) such as ataxia telangiectasia-mutated (ATM (Montrer ATM Protéines)).

Profil protéine TEL2, Telomere Maintenance 2, Homolog (S. Cerevisiae) (TELO2)

Profil protéine

This gene encodes a protein that functions as an S-phase checkpoint protein in the cell cycle. The protein may also play a role in DNA repair.

Gene names and symbols associated with TELO2

  • telomere maintenance 2 (Telo2)
  • telomere maintenance 2 (TELO2)
  • 1200003M09Rik Protéine
  • AI415602 Protéine
  • CLK2 Protéine
  • mKIAA0683 Protéine
  • RGD1305553 Protéine
  • TEL2 Protéine

Protein level used designations for TELO2

telomere length regulation protein TEL2 homolog , TEL2, telomere maintenance 2, homolog , protein clk-2 homolog

GENE ID SPECIES
302986 Rattus norvegicus
71718 Mus musculus
9894 Homo sapiens
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