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TELO2 encodes a protein that functions as an S-phase checkpoint protein in the cell cycle. De plus, nous expédions TEL2, Telomere Maintenance 2, Homolog (S. Cerevisiae) Anticorps (30) et et beaucoup plus de produits pour cette protéine.
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IP7, formed by IP6K2, binds CK2 to enhance its phosphorylation of the Tti1/Tel2 complex, thereby stabilizing DNA-PKcs and ATM. This process stimulates p53 phosphorylation at serine 15 to activate the cell death program.
The CK2 phospho-dependent interaction between TEL2 and the R2TP complex affects phosphatidylinositol 3-kinase-related kinase functions and is essential for mTOR and SMG1 stability in vivo.
Identify Tel2 as a highly conserved regulator of the stability of PI3K-related protein kinases.
Taken together, human high-grade gliomas increase TELO2 mRNA expression, and overexpression of TELO2 mRNA expression correlates with shorter survival outcome, supporting that TELO2 is an oncotarget in human gliomas.
TELO2 missense variants result in loss of function, perturb TTT complex stability, and cause an autosomal-recessive syndromic form of Intellectual Disability Disorder.
The SAM domain of human TEL2 can inhibit the transcriptional activities of ETS1/2 and TEL1.
Data show that that knockdown of either Tti1 or Tel2 causes disassembly of mTORC1 and mTORC2.
TTI1 and TTI2 exist in multiple complexes, including a 2-MDa complex with TEL2 (telomere maintenance 2), called the Triple T complex, and phosphoinositide-3-kinase-related protein kinases (PIKKs) such as ataxia telangiectasia-mutated (ATM).
This gene encodes a protein that functions as an S-phase checkpoint protein in the cell cycle. The protein may also play a role in DNA repair.
telomere length regulation protein TEL2 homolog
, TEL2, telomere maintenance 2, homolog
, protein clk-2 homolog