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The protein encoded by TRIM24 mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. De plus, nous expédions TRIM24 Protéines (7) et TRIM24 Kits (2) et beaucoup plus de produits pour cette protéine.
Showing 10 out of 124 products:
Human Polyclonal TRIM24 Primary Antibody pour IP, WB - ABIN251037
Levin, Panchabhai, Shen, Kornblau, Qiu, Baggerly: Different changes in protein and phosphoprotein levels result from serum starvation of high-grade glioma and adenocarcinoma cell lines. dans Journal of proteome research 2010
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Human Monoclonal TRIM24 Primary Antibody pour IF, IHC (p) - ABIN563797
Kikuchi, Okumura, Tsukiyama, Watanabe, Miyajima, Tanaka, Imamura, Hatakeyama: TRIM24 mediates ligand-dependent activation of androgen receptor and is repressed by a bromodomain-containing protein, BRD7, in prostate cancer cells. dans Biochimica et biophysica acta 2009
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Human Polyclonal TRIM24 Primary Antibody pour ICC, IF - ABIN251036
Allton, Jain, Herz, Tsai, Jung, Qin, Bergmann, Johnson, Barton: Trim24 targets endogenous p53 for degradation. dans Proceedings of the National Academy of Sciences of the United States of America 2009
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Human Polyclonal TRIM24 Primary Antibody pour IHC (p), IHC - ABIN268590
Thénot, Henriquet, Rochefort, Cavaillès: Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1. dans The Journal of biological chemistry 1997
Human Polyclonal TRIM24 Primary Antibody pour ICC, IF - ABIN4359700
Theurillat, Udeshi, Errington, Svinkina, Baca, Pop, Wild, Blattner, Groner, Rubin, Moch, Privé, Carr, Garraway: Prostate cancer. Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer. dans Science (New York, N.Y.) 2014
Results suggest that TRIM24 is a novel coactivator of the CAR that is involved in cell- and/or promoter- selective transactivation.
TRIM24 expression was increased in human colorectal cancer and might be a novel prognostic biomarker.
Study showed that TRIM24 was upregulated during gastric carcinogenesis and demonstrated that TRIM24 was a functional target gene of miR (Montrer MLXIP Anticorps)-511, and miR (Montrer MLXIP Anticorps)-511 inactivated PI3K (Montrer PIK3CA Anticorps)/AKT (Montrer AKT1 Anticorps) and Wnt (Montrer WNT2 Anticorps)/beta-catenin (Montrer CTNNB1 Anticorps) pathways by suppressing TRIM24.
Overexpression of KAT6A (Montrer MYST3 Anticorps) or TRIM24 promoted PIK3CA (Montrer PIK3CA Anticorps) expression, AKT (Montrer AKT1 Anticorps) phosphorylation, and cell proliferation.
we identified altered glucose metabolism in the progression of head and neck squamous cell carcinoma and showed that it could be partially attributed to the novel link between GLUT4 (Montrer SLC2A4 Anticorps) and TRIM24
This study concluded that reduced TRIM24 protein is associated with poor survival in esophageal squamous cell cancer (ESCC) patients, suggesting TRIM24 protein is a potential prognostic biomarker for ESCC.
Data suggest that, in cardiomyocytes, TRIM32 attenuates activation of SRF signaling and hypertrophy due to dysbindin; TRIM24 promotes these effects. TRIM32 promotes dysbindin degradation; TRIM24 protects dysbindin from degradation. (TRIM = tripartite motif-containing protein; SRF = serum response factor)
hypothesis of "synergistic modification induced recognition" is then proposed to link histone modification and TRIM24 binding
Report provides evidence for an oncogenic role for TRIM24 as a transcriptional activator and mediator of hormone-refractory prostate cancer cell growth in SPOP (Montrer SPOP Anticorps) mutant and castration-resistant prostate cells.
TRIM24 expression is positively correlated with Acetylated H3 lysine 23 levels, and high levels of both TRIM24 and Acetylated H3 lysine 23 predict shorter overall survival of breast cancer patients.
Maintenance of pluripotency is regulated by a network of transcription factors coordinated by Oct4 (Montrer POU5F1 Anticorps), Sox2 (Montrer SOX2 Anticorps), and Nanog (Montrer NANOG Anticorps); Trim24 significantly improved efficiency of cellular reprogramming, demonstrating its direct functionality in establishing pluripotency.
data identify a previously unappreciated Trim24-dependent requirement for IL-1R expression on TH2 cells and an important nonredundant role for T-cell-intrinsic Trim24 in TH2-mediated allergy and antihelminth immunity
Trim24 repressed VL30-class endogenous retroviruses retrotransposons
These results identify Trim24 as a novel negative regulator of the IFN/STAT (Montrer STAT1 Anticorps) pathway and suggest that this repression through Rara (Montrer RARA Anticorps) inhibition may prevent liver cancer.
Somatic hepatocyte-specific inactivation of TRIM24, TRIM28 (Montrer TRIM28 Anticorps), or TRIM33 (Montrer TRIM33 Anticorps) all promote hepatocellular carcinoma in a cell-autonomous manner in mice.
TRIM24 regulates AR-mediated transcription in collaboration with TIP60 (Montrer KAT5 Anticorps) and BRD7 (Montrer BRD7 Anticorps).
TIF1alpha-chromatin association is direct and involves DNA and nucleosome interactions mediated by the bromodomain
These studies indicate that TIF1alpha is a factor that modulates the expression of a set of genes during the first wave of genome activation in the mouse embryo.
The results not only provide genetic evidence that Trim24 and Rara (Montrer RARA Anticorps) co-regulate hepatocarcinogenesis in an antagonistic manner but also suggest that aberrant activation of Rara (Montrer RARA Anticorps) is deleterious to liver homeostasis.
TIF1alpha-null mutant pathological phenotype supports the hypothesis that aging is promoted by increased activity of the vitamin D signaling pathway
The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.
tripartite motif-containing 24
, transcriptional intermediary factor 1 alpha
, tripartite motif containing 24
, E3 ubiquitin-protein ligase TRIM24
, RING finger protein 82
, transcription intermediary factor 1-alpha
, transcriptional intermediary factor 1
, E3 ubiquitin-protein ligase Trim24
, transcriptional intermediary factor 1, alpha
, tripartite motif-containing protein 24