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TP53BP2 encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. De plus, nous expédions Tumor Protein P53 Binding Protein 2 Kits (4) et Tumor Protein P53 Binding Protein 2 Protéines (3) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal TP53BP2 Primary Antibody pour IF (p), IHC (p) - ABIN674394
Xie, Yang, Chi, Yang, Wang, Xu: Prognostic values of apoptosis-stimulating P53-binding protein 1 and 2 and their relationships with clinical characteristics of esophageal squamous cell carcinoma patients: a retrospective study. dans Chinese journal of cancer 2017
Human Polyclonal TP53BP2 Primary Antibody pour IHC, ELISA - ABIN1584022
Matsumoto, Weckbecker, Cory: Antineoplastic effect of the combination of 2,3-dihydro-1H-pyrazole[2,3a]imidazole plus deoxyadenosine/erythro-9-(2-hydroxyl-3-nonyl)adenine in mice with L1210 leukemia cells. dans Cancer communications 1990
Show all 2 Pubmed References
These findings identify TP53BP2 as a strong candidate causative gene for central nervous system (CNS) defects in 1q41q42 microdeletion syndrome.
Results showed that protein expression levels of ASPP2 and P53 (Montrer TP53 Anticorps) were significantly higher in esophageal squamous cell carcinoma tissues than in paired noncancerous tissues.
Expression levels of TP53BP2, FBXO28 (Montrer FBXO28 Anticorps), and FAM53A (Montrer Fam53a Anticorps) genes were associated with patient survival specifically in ER-positive, TP53 (Montrer TP53 Anticorps)-mutated tumors.
These data together implicated a critical impact of MiR (Montrer MLXIP Anticorps)-205/ASPP2 on promoting epithelial-mesenchymal transition.
ASPP2 is a key regulator of BECN1 (Montrer BECN1 Anticorps)-dependent autophagy.
ASPP2 suppresses invasion, peritoneal dissemination and TGF-beta1 (Montrer TGFB1 Anticorps)-induced EMT (Montrer ITK Anticorps) by inhibiting Smad7 (Montrer SMAD7 Anticorps) degradation mediated by ITCH in gastric cancer cells.
Our results suggest that Gal-1 and ASPP2 functionally compete in nanocluster for active Ras on the plasma membrane. ASPP2 dominates the biological outcome, thus switching from a Gal-1 supported growth-promoting setting to a senescence inducing and stemness suppressive program in cancer cells. Our results support Ras nanocluster as major integrators of tumour fate decision events.
ASPP2 suppresses p53 (Montrer TP53 Anticorps) target gene transactivation, promoter occupancy, and endogenous p53 (Montrer TP53 Anticorps) target gene expression in response to DNA damage
In this study, in recombinant adenovirus-ASPP2-infected HepG2 cells, ASPP2 overexpression induces amphiregulin (Montrer AREG Anticorps) expression in a p53 (Montrer TP53 Anticorps)-dependent manner
Downregulated expression of ASPP2 is associated with hepatocellular carcinoma.
These findings uncover a novel role of Aspp2 in regulating vertebrate embryonic growth.
These results suggest that ASPP2 plays an important role in p53 (Montrer TP53 Anticorps)-mediated neuronal apoptosis under gp120 (Montrer ITIH4 Anticorps) stress.
SPP2 dominates the biological outcome, thus switching from a Gal-1 supported growth-promoting setting to a senescence inducing and stemness suppressive program in cancer cells. Our results support Ras nanocluster as major integrators of tumour fate decision events.
ASPP2 may participate in the lipid metabolism of non-alcoholic steatohepatitis and attenuate liver failure.
ASPP2 prevents beta-catenin (Montrer CTNNB1 Anticorps) from transactivating ZEB1 (Montrer ZEB1 Anticorps) directly by forming an ASPP2-beta-catenin (Montrer CTNNB1 Anticorps)-E-cadherin (Montrer CDH1 Anticorps) ternary complex
findings suggest that the identified STAT1 (Montrer STAT1 Anticorps)/ASPP2 pathway may connect tumor suppression and cell polarity to neuroinflammation
our studies demonstrate the role of Siah2 (Montrer SIAH2 Anticorps) in regulation of tight junction integrity and cell polarity under hypoxia, through its regulation of ASPP2 stability.
ASPP2 is a tumor suppressor that suppresses squamous cell carcinoma via inflammatory signaling through NF-kappaB (Montrer NFKB1 Anticorps)-mediated repression of p63 (Montrer CKAP4 Anticorps).
Our study demonstrates a novel role for ASPP1 (Montrer PPP1R13B Anticorps) and ASPP2 in the death of retinal ganglion cells.
regulates epithelial cell polarity in cooperation with PAR-3 (Montrer F2RL2 Anticorps) to form an active PAR (Montrer AFG3L2 Anticorps) complex
This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene.
, apoptosis-stimulating of p53 protein 2
, apoptosis-stimulating protein of p53, 2
, renal carcinoma antigen NY-REN-51
, tumor suppressor p53-binding protein 2
, tumor protein p53 binding protein, 2
, apoptosis-stimulating of p53 protein 2-like
, p53-binding protein 2
, transformation related protein 53 binding protein 2