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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. De plus, nous expédions UBE2B Protéines (22) et UBE2B Kits (4) et beaucoup plus de produits pour cette protéine.
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These results point to an important role of the affinity between RNF4 (Montrer RNF4 Anticorps) and its cognate RAD6B or UBCH5B (Montrer UBE2D2 Anticorps) in governing the multiplicity of substrate ubiquitination.
RAD6 promotes proteasome activity and nuclear translocation by enhancing the degradation of PSMF1 (Montrer PSMF1 Anticorps) and the lamin B receptor (Montrer LBR Anticorps).
In conclusion, we reveal that miR (Montrer MLXIP Anticorps)-455-5p expression is regulated by the TGF-beta (Montrer TGFB1 Anticorps)-dependent pathway, which subsequently leads to UBE2B down-regulation and contributes to oral cancer tumourigenesis.
Data show that the ubiquitin-conjugating enzyme E2 RAD6A/B-MDM2 ubiquitin ligase machinery regulates anti-silencing function 1A protein (ASF1A) degradation.
A novel variant (Chr5.133706925 A > G) residing in the UBE2B gene promoter region confers a high risk for idiopathic azoospermia in a Chinese population.
RAD6 physically interacts with heterochromatin protein 1alpha and ubiquitinates HP1alpha (Montrer CBX5 Anticorps) at residue K154, thereby promoting heterochromatin protein 1alpha degradation through the autophagy pathway
UBE2B mRNA alterations are associated with severe oligozoospermia in infertile men.
RNF168 (Montrer RNF168 Anticorps), in complex with RAD6A (Montrer ube2a Anticorps) or RAD6B, is activated in the DNA-damage-induced protein ubiquitination cascade.
UBE2B polymorphisms g.-293T>G, g.20016A>G and g.9157A>G are not associated with male infertility, and the GA haplotype is likely a protective factor for male fertility in Northeast Chinese men.
beta-catenin (Montrer CTNNB1 Anticorps) and Rad6B interacting regions, were identified.
These results suggest that Ube2b, as a direct androgen receptor transcriptional target in Sertoli cells, mediates the function of androgen recpetor in spermatogenesis by promoting H2A ubiquitylation.
HR6B represses major satellite repeat transcription in spermatocytes, and functions in the maintenance of X chromosome silencing in spermatocytes and spermatids.
The present findings reveal a specific requirement for the ubiquitin-conjugating activity of HR6B in relation to dynamic aspects of the synaptonemal complex and meiotic recombination in spermatocytes.
Ube2b deficient mice are shown to present male infertility and sperm head shape anomalies.
HR6B exerts control over different histone modifications in spermatocytes and spermatids, and that this function contributes to the postmeiotic maintenance of X chromosome silencing.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution.
Ubiquitin-conjugating enzyme E2 B
, ubiquitin-conjugating enzyme E2 B
, ubiquitin-conjugating enzyme E2B (RAD6 homolog)
, ubiquitin-conjugating enzyme E2
, E2 protein
, RAD6 homolog B
, ubiquitin carrier protein B
, ubiquitin-conjugating enzyme E2-17 kDa
, ubiquitin-protein ligase B
, ubiquitin-conjugating enzyme E2B, RAD6 homology
, ubiquitin conjugating enzyme
, ubiquitin-conjugating enzyme E2(14k)
, ubiquitin-conjugating enzyme E2B (RAD6 homolog, S. cerevisiae)
, ubiquitin-conjugating enzyme E2B, RAD6 homolog
, ubiquitin conjugating-protein