phosphoprotein Enriched in Astrocytes 15 Protéines (PEA15)

PEA15 encodes a death effector domain-containing protein, which is a major phosphoprotein in astrocytes, and an endogenous substrate for protein kinase C. De plus, nous expédions PEA15 Anticorps (127) et PEA15 Kits (4) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
PEA15 8682 Q15121
Rat PEA15 PEA15 364052 Q5U318
PEA15    
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Top PEA15 Protéines sur anticorps-enligne.fr

Showing 9 out of 11 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Escherichia coli (E. coli) Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 30 to 35 Days
$5,370.21
Détails
Escherichia coli (E. coli) Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 30 to 35 Days
$5,370.21
Détails
Escherichia coli (E. coli) Humain Inconjugué Figure annotation denotes ug of protein loaded and % gel used. 100 μg Connectez-vous pour afficher 9 to 11 Days
$680.36
Détails
Escherichia coli (E. coli) Humain Inconjugué   50 μg Connectez-vous pour afficher 4 Days
$385.00
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher 11 Days
$888.80
Détails
Wheat germ Humain GST tag 25 μg Connectez-vous pour afficher 11 to 12 Days
$602.86
Détails
Escherichia coli (E. coli) Humain Inconjugué   10 μg Connectez-vous pour afficher 15 to 16 Days
$225.00
Détails
Escherichia coli (E. coli) Humain Inconjugué   1 mg Connectez-vous pour afficher 2 to 3 Days
$6,867.69
Détails
Humain Inconjugué   1 mg Connectez-vous pour afficher 6 Days
$7,816.29
Détails

PEA15 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , ,
, ,
Mouse (Murine)

Plus protéines pour phosphoprotein Enriched in Astrocytes 15 (PEA15) partenaires d'interaction

Human phosphoprotein Enriched in Astrocytes 15 (PEA15) interaction partners

  1. Study showed that PEA15 was highly expressed in colorectal cancer and liver metastatic cancer tissues and positively correlated with TNM staging, liver metastasis and poor prognosis. PEA15 may be a potential biomarker for liver metastasis of colorectal cancer therapy. Collectively, PEA15 promoted the development of liver metastasis of colorectal cancer through the ERK/MAPK signaling pathway.

  2. Data suggest that PED has a prominent role in HCC biology. It acts particularly on promoting cell migration and confers resistance to sorafenib treatment.

  3. PP4 regulates breast cancer cell survival and identifies a novel PP4c-PEA15 signalling axis in the control of breast cancer cell survival.

  4. PEA15 expression was not significantly correlated with ovarian cancer antineoplastic drug resistance.

  5. Data suggest the role of the phospholipase C epsilon-Protein kinase D-PEA15 protein-ribosomal S6 kinase-IkappaB-NF-kappa B pathway in facilitating inflammation and inflammation-associated carcinogenesis in the colon.

  6. Integrin alpha5beta1 and p53 convergent pathways in the control of anti-apoptotic proteins PEA-15 and survivin in high-grade glioma.

  7. High PED expression is associated with esophageal carcinoma.

  8. The nuclear translocation of SApErk1/ 2 apart from PEA-15 as an important mechanism to reverse senescence phenotype.

  9. Latent HCMV infection of CD34 + cells protects cells from FAS-mediated apoptosis through the cellular IL-10/PEA-15 pathway.

  10. New therapeutic targets based around PEA-15 and its associated interactions are now being uncovered and could provide novel avenues for treatment strategies in multiple diseases.

  11. PED/PEA-15 overexpression is sufficient to block hydrogen peroxide-induced apoptosis in Ins-1E cells through a PLD-1 mediated mechanism

  12. Omi/HtrA2 overexpression promotes hepatocellular carcinoma cell apoptosis and the ped/pea-15 expression level causes this difference of the Omi/HtrA2 pro-apoptotic marker in the various hepatocellular carcinoma cell lines

  13. Results suggest that neurochemical adaptations of brain FADD, as well as its interaction with PEA-15, could play a major role to counteract the known activation of the mitochondrial apoptotic pathway in major depression

  14. Data show that phosphoprotein enriched in astrocytes of 15 kDa (PEA-15) influences dephosphorylation of epidermal growth factor receptor (EGFR) via extracellular signal-regulated kinases ERK1/2 sequestration in the cytoplasm.

  15. Tumor suppressor PEA15 is a regulator of genome integrity and is an integral component of the DNA damage response pathway.

  16. Up-regulated chaperone-mediated autophagy activity characteristic of most types of cancer cell enhances oncogenesis by shifting the balance of PED function toward tumor promotion.

  17. Our findings highlight the importance of pPEA-15 as a promising target for improving the efficacy of paclitaxel-based therapy in ovarian cancer.

  18. PEA-15 binding protects ERK2 from dephosphorylation, thus setting the stage for immediate ERK activity upon its release from the PEA-15 inhibitory complex

  19. study demonstrates that the PEA-15 protein decreases proliferation, clonogenicity, and invasiveness, but increases resistance to apoptosis in colorectal carcinoma cells

  20. The article hypothesizes that only unphosphorylated PEA-15 can act as a tumor-suppressor and that phosphorylation alters the interaction with binding partners to promote tumor development.

Profil protéine PEA15

Profil protéine

This gene encodes a death effector domain-containing protein, which is a major phosphoprotein in astrocytes, and an endogenous substrate for protein kinase C. Studies using knockout mice suggest that this protein may protect astrocytes from TNF-induced apoptosis. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake.

Gene names and symbols associated with PEA15

  • proliferation and apoptosis adaptor protein 15 (PEA15)
  • proliferation and apoptosis adaptor protein 15 (Pea15)
  • phosphoprotein enriched in astrocytes 15 (PEA15)
  • proliferation and apoptosis adaptor protein 15 L homeolog (pea15.L)
  • proliferation and apoptosis adaptor protein 15 (pea15)
  • Astrocytic phosphoprotein PEA-15 (pea15)
  • phosphoprotein enriched in astrocytes 15 (pea15)
  • DKFZp459O1410 Protéine
  • HMAT1 Protéine
  • HUMMAT1H Protéine
  • MAT1 Protéine
  • MAT1H Protéine
  • PEA-15 Protéine
  • PEA15 Protéine
  • Pea15a Protéine
  • PED Protéine

Protein level used designations for PEA15

15 kDa phosphoprotein enriched in astrocytes , Phosphoprotein enriched in astrocytes, 15kD , astrocytic phosphoprotein PEA-15 , homolog of mouse MAT-1 oncogene , phosphoprotein enriched in diabetes , phosphoprotein enriched in astrocytes 15A , phosphoprotein enriched in astrocytes 15 , Astrocytic phosphoprotein PEA-15

GENE ID SPECIES
8682 Homo sapiens
364052 Rattus norvegicus
510586 Bos taurus
610113 Canis lupus familiaris
705026 Macaca mulatta
734852 Xenopus laevis
100145359 Xenopus (Silurana) tropicalis
100152480 Sus scrofa
100174153 Pongo abelii
100286636 Salmo salar
100730336 Cavia porcellus
557745 Danio rerio
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