anti-tyrosyl-DNA phosphodiesterase 2 (TDP2) Anticorps

TDP2 encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. De plus, nous expédions TDP2 Protéines (12) et et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
TDP2 51567 O95551
TDP2 56196 Q9JJX7
TDP2 498749 Q3T1H5
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Top anti-TDP2 Anticorps sur anticorps-enligne.fr

Showing 10 out of 112 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué IHC, WB WB Suggested Anti-TTRAP Antibody Titration:  0.2-1 ug/ml  Positive Control:  HepG2 cell lysate TDP2 is supported by BioGPS gene expression data to be expressed in HepG2 Sample: 1. DT40 (5x105cells)2. DT40 + rec. hTDP2 (5x105cells)3. soluble HIS-hTDP2 (5x105cells)4. pellet HIS-hTDP2 (5x105cells)Primary dilution:1:1000Secondary Antibody: dakocytomation Goat anti-rabbitSecondary dilution: 1:5000Image Submitted by: Keith CaldecottUniversity of Sussex 100 μL 2 to 3 Days
$289.00
Détails
Humain Lapin Inconjugué IHC, IHC (p), WB Human Kidney (formalin-fixed, paraffin-embedded) stained with TTRAP antibody ABIN214210 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Anti-TDP2 / TTRAP antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μg 11 to 14 Days
$484.00
Détails
Roussette (Chauve-souris) Lapin Inconjugué IHC, IHC (p), WB 100 μL 11 to 14 Days
$551.83
Détails
Humain Lapin Inconjugué IHC, ELISA, WB 50 μg 2 to 3 Days
$375.00
Détails
Humain Lapin Inconjugué ICC, IF, IHC, IHC (p), WB Anti-TDP2 / TTRAP antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 7.5 ug/ml. 50 μL 11 to 14 Days
$484.00
Détails
Humain Lapin Inconjugué IHC (p), WB 50 μg 6 to 8 Days
$495.00
Détails
Humain Lapin Inconjugué EIA, FACS, IF, IHC (p), WB   0.4 mL 4 to 8 Days
$522.50
Détails
Humain Souris Inconjugué ELISA, WB 100 μL 11 to 14 Days
$625.17
Détails
Humain Lapin Inconjugué FACS, IF, IHC (p), WB Western blot analysis in A549 cell line lysates (35ug/lane). EAPII Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human prostate carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL 2 to 3 Days
$515.63
Détails
Humain Souris Inconjugué ELISA, IHC, IHC (p), WB 100 μg 11 to 14 Days
$551.83
Détails

anti-TDP2 Anticorps mieux référencés

  1. Human Polyclonal TDP2 Primary Antibody pour IF, WB - ABIN526818 : Thomson, Watson, Caldecott, Denneny, Depledge, Hamilton, Hopkins, Jordan, Morrow, Raoof, Waddell, Ogilvie: Generation of assays and antibodies to facilitate the study of human 5'-tyrosyl DNA phosphodiesterase. dans Analytical biochemistry 2013 (PubMed)

  2. Human Polyclonal TDP2 Primary Antibody pour ICC, IF - ABIN4309668 : Virgen-Slane, Rozovics, Fitzgerald, Ngo, Chou, van der Heden van Noort, Filippov, Gershon, Semler: An RNA virus hijacks an incognito function of a DNA repair enzyme. dans Proceedings of the National Academy of Sciences of the United States of America 2012 (PubMed)

  3. Cow (Bovine) Polyclonal TDP2 Primary Antibody pour IHC, WB - ABIN2777707 : Pei, Yordy, Leng, Zhao, Watson, Li: EAPII interacts with ETS1 and modulates its transcriptional function. dans Oncogene 2003 (PubMed)
    Show all 2 Pubmed References

Plus d’anticorps contre TDP2 partenaires d’interaction

Human tyrosyl-DNA phosphodiesterase 2 (TDP2) interaction partners

  1. Data suggest that tyrosyl-DNA Phosphodiesterases 1 (TDP1) and 2 (TDP2) are promising therapeutic targets and their inhibitors are expected to significantly synergize the effects of current anti-tumor therapies [Review].

  2. lack of TDP2 in the mitochondria reduces the mitochondria transcription levels in two different human cell lines. In addition to identifying a novel TDP2(S) isoform, our report demonstrates the presence and importance of both TDP2 isoforms in the mitochondria.

  3. Data indicate that tyrosyl-DNA phosphodiesterase 2 (TDP2) alone does not remove DNA topoisomerase II (TOP2)-DNA complexes from genomic DNA in vitro and that depletion of TDP2 in cells does not slow the removal of TOP2-DNA complexes.

  4. TDP2 re-localizes from the nucleus to the cytoplasm of EMCV infected cells.

  5. These findings uncover a ZNF451-TDP2-catalyzed and SUMO2-modulated pathway for direct resolution of TOP2 cleavage complex.

  6. TDP2 suppresses chromosome rearrangements induced by TOP2 and reduces TOP2-induced chromosome translocations that arise during gene transcription.

  7. Both the genome instability and cell death of MRE11-null and MRE11-mutated H129N cells are significantly reversed by overexpression of Tdp2, an enzyme that eliminates covalent Top2 conjugates; thus, the essential role of Mre11 nuclease activity is likely to remove the DNA lesions.

  8. Study revealed a post-translational regulation of TDP2 activity and discovered a new role of ERK3 in increasing cancer cells' DNA damage response and chemoresistance to Top2 inhibitors.

  9. Data show that DNA-repair enzyme TDP2 knockdown in HepG2 cells significantly delays the conversion of relaxed circular DNA (RC-DNA) to covalently closed circular (ccc) DNA.

  10. This article summarizes and compares the biochemistry, functions, and post-translational regulation of TDP1 and TDP2, as well as the relevance of TDP1 and TDP2 as determinants of response to anticancer agents

  11. Proteolytic degradation of Top2 enables the processing of Top2.DNA and Top2.RNA covalent complexes by TDP2.

  12. TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function.

  13. Mutations in the 5'-tyrosyl-DNA phosphodiesterase activity of TTRAP,in particular TTRAP(E152A), showed decreased inhibitory activity on cell growth.

  14. Magnesium is indispensable for a 5'-tyrosyl DNA phosphodiesterase activity.

  15. VPg unlinkase activity in different mammalian cell lines correlates with their differential expression of TDP2.

  16. Biochemical characterization of human tyrosyl-DNA phosphodiesterase 2 (TDP2/TTRAP): a Mg(2+)/Mn(2+)-dependent phosphodiesterase specific for the repair of topoisomerase cleavage complexes.

  17. findings suggest a previously unidentified function for TTRAP and nucleolar cavities in ribosome biogenesis under stress.

  18. both FOXP2 and KIAA0319/TTRAP/THEM2 genes play an important role in human language development, but probably through different cerebral pathways.

  19. EAPII is an oncogenic factor and the activation of MAPK-ERK signaling pathway by EAPII may contribute to lung cancer development.

  20. an important mechanism for resistance to Top2-induced chromosome breakage and the possibility that TDP2 is a significant factor in cancer development and treatment

Mouse (Murine) tyrosyl-DNA phosphodiesterase 2 (TDP2) interaction partners

  1. EMCV yields are significantly reduced during infection of mouse embryonic fibroblasts genetically ablated for TDP2.

  2. The results collectively provide a structural mechanism for Tdp2 engagement of heterogeneous DNA damage that causes Top2 poisoning.

  3. data show that TDP2 activity potentiates enterovirus infections and, in the case of coxsackievirus B3, is a required host function following virus infection of mouse cells

  4. our data reveal TDP2-mediated error-free NHEJ as an efficient and accurate mechanism to repair TOP2-induced DSBs

  5. Evidence implicates Tdp2 in the repair of Top1-mediated DNA damage in cultured cells and in vivo, in the absence of Tdp1.

  6. the protein associates with TGF-beta receptors and components of the TRAF6-TAK1 signaling module

Zebrafish tyrosyl-DNA phosphodiesterase 2 (TDP2) interaction partners

  1. although the role of Smad proteins in mediating Nodal signaling is well-documented, the functional characterization of Ttrap provides insight into a novel Smad partner that plays an essential role in the fine-tuning of this signal transduction cascade

TDP2 profil antigène

Profil protéine

This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors.

Gene names and symbols associated with TDP2

  • tyrosyl-DNA phosphodiesterase 2 (TDP2) anticorps
  • tyrosyl-DNA phosphodiesterase 2 S homeolog (tdp2.S) anticorps
  • tyrosyl-DNA phosphodiesterase 2 (Tdp2) anticorps
  • tyrosyl-DNA phosphodiesterase 2b (tdp2b) anticorps
  • ad022 anticorps
  • D13Ertd656e anticorps
  • dJ30M3.3 anticorps
  • eap2 anticorps
  • EAPII anticorps
  • hTDP2 anticorps
  • tdp2 anticorps
  • Ttrap anticorps
  • ttrapl anticorps

Protein level used designations for TDP2

5'-Tyr-DNA phosphodiesterase , 5'-tyrosyl-DNA phosphodiesterase , ETS1-associated protein 2 , ETS1-associated protein II , TRAF and TNF receptor associated protein , TRAF and TNF receptor-associated protein , VPg unlinkase , tyr-DNA phosphodiesterase 2 , tyrosyl-RNA phosphodiesterase , TRAF and TNF receptor-associated protein homolog , Tyr-DNA phosphodiesterase 2 , Traf and Tnf receptor associated protein , immune transcriptional repressor , traf and tnf receptor associated protein, like , tyrosyl-DNA phosphodiesterase 2

GENE ID SPECIES
51567 Homo sapiens
100049743 Xenopus laevis
421007 Gallus gallus
507579 Bos taurus
56196 Mus musculus
498749 Rattus norvegicus
553516 Danio rerio
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