Charybdotoxin

N° du produit ABIN1540031

Détail du produit

Antigène: Charybdotoxin

Application: Blocking Reagent (BR)

Fonction: Charybotoxin blocks Kca channels

Séquence: Pyr-Phe-Thr-Asn-Val-Ser-Cys7-Thr-Thr-Ser-Lys-Glu-Cys13-Trp-Ser-Val-Cys17-Gln-Arg-Leu-His-Asn-Thr-Ser-Arg-Gly-Lys-Cys28-Met-Asn-Lys-Lys-Cys33-Arg-Cys35-Tyr-Ser-OH(Disulfide bonds between Cys7-Cys28, Cys13-Cys33, and Cys17-Cys35)

Information d'application

Restrictions: For Research Use only

Stockage

Détail du antigène

Antigène: Charybdotoxin

Sujet: Charybdotoxin is a 37 amino acid peptide isolated from the venom of the scorpion Leiurus quinquestriatus hebraeus that blocks voltage gated and Ca2+ activated K+ channels. This blockade causes hyperexcitability of the nervous system. The toxin reversibly blocks channel activity by interacting at the external pore of the channel protein with an apparent Kd of 2.1 nM. ChTX also blocks Kv1.2 (Kd 14 nM) and Kv1.3 (Kd 2.6nM) channels.

Poids moléculaire: 4295.9 Da

Numéro CAS: 95751-30-7