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anti-Human Cathepsin K Anticorps:
anti-Mouse (Murine) Cathepsin K Anticorps:
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Chicken Polyclonal Cathepsin K Primary Antibody pour IP, IHC - ABIN223282
López-Guisa, Cai, Collins, Yamaguchi, Okamura, Bugge, Isacke, Emson, Turner, Shankland, Eddy: Mannose receptor 2 attenuates renal fibrosis. dans Journal of the American Society of Nephrology : JASN 2012
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Human Monoclonal Cathepsin K Primary Antibody pour IHC (p), ELISA - ABIN514786
Cordes, Bartling, Simm, Afar, Lautenschläger, Hansen, Silber, Burdach, Hofmann: Simultaneous expression of Cathepsins B and K in pulmonary adenocarcinomas and squamous cell carcinomas predicts poor recurrence-free and overall survival. dans Lung cancer (Amsterdam, Netherlands) 2009
Human Polyclonal Cathepsin K Primary Antibody pour EIA, ELISA - ABIN409081
Asagiri, Hirai, Kunigami, Kamano, Gober, Okamoto, Nishikawa, Latz, Golenbock, Aoki, Ohya, Imai, Morishita, Miyazono, Kato, Saftig, Takayanagi: Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis. dans Science (New York, N.Y.) 2008
Patients affected by castration-resistant prostate carcinoma may be tested for cathepsin K, and a positive strong expression (2+) could be a useful predictive biomarker of response to targeted agents, aiding in the selection of patients eligible for these treatments.
Of 160 top compounds tested in enzymatic assays, 28 compounds showed blocking of the collagenase activity of Cathepsin K (CatK) at 100 muM.
Cathepsin K cleavage of SDF-1alpha inhibits its chemotactic activity towards glioblastoma stem-like cells.
Increased cathepsin K expression in skull base chordoma was associated with tumor invasion and reduced progression free survival.
Immunohistochemistry confirmed cathepsin K protein was expressed in lymphangioleiomyomatosis but not control lungs. Cathepsin K gene expression and protein and protease activity were detected in lymphangioleiomyomatosis -associated fibroblasts but not the LAM (Montrer TSC1 Anticorps) cell line 621-101.
The allosteric site of cathepsin K has been modified by site-directed mutagenesis, and it was shown that it is involved in specific regulation of the collagenolytic activity of cathepsin K.
Cathepsin K and osteocalcin (Montrer BGLAP Anticorps) plasma levels may be suggested as the significant markers of osteopoenia/osteoporosis. In addition, cathepsin K plasma level can be also a valuable marker of severe Coronary Atherosclerosis and Coronary Artery Calcification .
Six mutations in CTSK were identified in 33 families with pycnodysostosis. The high frequency of pycnodysostosis in Ceara State is the consequence of the high inbreeding in that region.
The above studies not only demonstrated that CTSK was widely expressed in tooth-related cells (including odonto- clasts, periodontal ligament cells, pulp cells and odonto- blasts), but also indicated that CTSK was closely related to the development of tissues in oral and maxillofacial region as well as occurrence and development of many oral diseases.
This mutation (c.480_481insT), (p.L160fsX173) is a novel frameshift mutation. The index case extends the phenotypic spectrum and the list of previously reported mutations in the CTSK gene.
This study established a possible role of CatK in TLR7 (Montrer TLR7 Anticorps) proteolytic activation, Treg immunosuppressive activity, and lupus autoimmunity and pathology.
catK deficiency almost completely blunted the increased vascular remodeling response of apoE (Montrer APOE Anticorps)-/- mice to flow cessation, possibly by correcting hyperlipidemia-associated pro-inflammatory effects on the peripheral immune response
The effects of muscarinic receptor (Montrer CHRM5 Anticorps) M3 knockout on cathepsin K expression, bone density and biomechanical properties of bone are reported.
Cathepsin K expression is increased in the bone of a diabetic mouse model.
Data suggest Ctsk gene, key gene upregulated during osteoclast differentiation, is transcriptionally activated during cell hypoxia-induced mitochondrial dysfunction/disruption; hnRNPA2 (heterogeneous ribonucleoprotein A2) is coactivator in this process.
cathepsin K knockout attenuates age-related decline in cardiac function via suppressing caspase (Montrer CASP3 Anticorps)-dependent and caspase (Montrer CASP3 Anticorps)-independent apoptosis
Data (including data from studies in knockout/transgenic mice) suggest that Ctsk is involved in inflammatory response and bone resorption in both rheumatoid arthritis and periodontitis; thus, Ctsk appears to play a role in osteoimmune responses.
In a mouse model of post-traumatic osteoarthritis, cathepsin K activity was significantly increased in injured knees relative to uninjured knees.
Gene deletion of cathepsin K in mice accelerated callus size resolution, significantly increased callus mineralized mass, and improved mechanical strength as compared to wild type mice.
synergism between HIV proteins and pro-atherogenic shear stress to increase endothelial cell expression of the powerful protease cathepsin K
The CTSK marker was associated with back fat thickness and lean cuts (P < 0.01), and average daily gain and feed:gain ratio (P < 0.05) estimated breeding values.
components of the large latent TGFss complex were identified as novel targets of cathepsin K at neutral pH.
The authors showed CTSK upregulation in human lung specimens and elevated serum CTSK levels of patients with tuberculosis, compared with controls.
Down-regulation of cathepsin K in synovium at the initial stage of osteoarthritis significantly accelerated cartilage degeneration.
CatK inhibition in horses did affect bone marrow nucleated cells other than mature osteoclasts rendering them hypo-responsive to both TLR4 (Montrer TLR4 Anticorps)- and TLR9 (Montrer TLR9 Anticorps)-induced inflammation, predicting a proteolytic activity for CatK within the MyD88 (Montrer MYD88 Anticorps) pathway and/or the following proteolytic events required for the cytokines secretion.
The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature.
, cathepsin O1
, cathepsin O2
, cathepsin X
, Cat K
, minisatellite 10q detected by probe MMS10
, cathepsin K
, cathepsin K preproprotein
, cathepsin K (pycnodysostosis)
, protein OC-2
, Cathepsin K