HSP27 anticorps

N° du produit ABIN100223

Détail du produit anti-HSP27 anticorps

Antigène: HSP27 (HSPB1) (Heat Shock 27kDa Protein 1 (HSPB1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp HSP27 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP)

Attributs du produit: Concentration Definition: by UV absorbance at 280 nm

Stérilité: Sterile filtered

Immunogène: This HSP27 monoclonal antibody was produced by repeated immunizations with a prokaryotic recombinant protein corresponding to the full length human hsp27 protein.
Immunogentype:Recombinant

Clone: G3-1

Isotype: IgG

Information d'application

Indications d'application: This protein A purified monoclonal antibody against human Hsp27 has been tested for use in immunoblotting, immunoprecipitation, ELISA, immunohistochemistry and immunocytochemistry.  The antibody recognizes a 27 kDa band corresponding to hsp27 in cell lysates from breast carcinoma.    Both frozen sections and paraffin embedded material can be used for immunocytochemistry and immunohistochemistry.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.5 M Sodium Chloride, pH 7.2

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Références pour anticorps anti-HSP27 (ABIN100223)

McGuire, Fuqua, Naylor, Helin-Davis, McGuire: "Chromosomal assignments of human 27-kDa heat shock protein gene family." dans: Somatic cell and molecular genetics, Vol. 15, Issue 2, pp. 167-71, (1989) (PubMed).

Moretti-Rojas, Fuqua, Montgomery, McGuire: "A cDNA for the estradiol-regulated 24K protein: control of mRNA levels in MCF-7 cells." dans: Breast cancer research and treatment, Vol. 11, Issue 2, pp. 155-63, (1988) (PubMed).

Edwards, Adams, McGuire: "Estradiol stimulates synthesis of a major intracellular protein in a human breast cancer cell line (MCF-7)." dans: Breast cancer research and treatment, Vol. 1, Issue 3, pp. 209-23, (1983) (PubMed).

Détails sur HSP27

Antigène: HSP27 (HSPB1) (Heat Shock 27kDa Protein 1 (HSPB1))

Autre désignation: HSP27 (HSPB1 Produits)

Synonymes: anticorps CMT2F, anticorps HMN2B, anticorps HS.76067, anticorps HSP27, anticorps HSP28, anticorps Hsp25, anticorps SRP27, anticorps 27kDa, anticorps Hsp27, anticorps cb153, anticorps cb660, anticorps hsp1, anticorps hsp25, anticorps hsp27, anticorps id:ibd2821, anticorps sb:cb660, anticorps zgc:103437, anticorps HSPB1, anticorps cmt2f, anticorps hs.76067, anticorps hsp28, anticorps heat shock protein family B (small) member 1, anticorps heat shock protein 1, anticorps heat shock protein, alpha-crystallin-related, 1, anticorps heat shock protein family B (small) member 1 L homeolog, anticorps HSPB1, anticorps Hspb1, anticorps hspb1, anticorps hspb1.L

Sujet: Heat shock protein (HSP) 27 is one of the small HSPs that are constitutively expressed at different levels in different cell types and tissues (this protein has also been referred to as the Estrogen-Regulated 24 kDa protein, hsp25 and hsp28).   Like other small heat shock proteins, HSP27 is regulated at both the transcriptional and post-translational level.  In response to stress, the expression level of HSP27 increases several-fold to confer cellular resistance to the adverse environmental change.  Human HSP27 shares greater than 50% homology with the low molecular weight Drosophila HSP and mammalian crystalline lens protein.  Because of the estrogen responsive nature of HSP27, the protein has been extensively
Synonyms: Heat shock protein beta-1 antibody, HspB1 antibody, Heat shock 27 kDa protein antibody, Stress-responsive protein 27 antibody, SRP27 antibody, Estrogen-regulated 24 kDa protein antibody, 28 kDa heat shock protein antibody

ID gène: 39078, 17647521

UniProt: P04792

Pathways: Signalisation MAPK, Regulation of Actin Filament Polymerization, Signaling Events mediated by VEGFR1 and VEGFR2, Negative Regulation of intrinsic apoptotic Signaling, VEGF Signaling