SLC12A4 anticorps (AA 932-1043)

N° du produit ABIN1043014

Détail du produit anti-SLC12A4 anticorps

Antigène: SLC12A4 (Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 4 (SLC12A4))

Épitope: AA 932-1043

Reactivité: Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SLC12A4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (fixed cells) (IF/ICC), Immunoprecipitation (IP)

Fonction: Anti-K+/Cl-Cotransporter (KCC2) Mouse Monoclonal Antibody

Specificité: This antibody recognizes human, mouse and rat KCC2.

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein G affinity chromatography.

Immunogène: Fusion protein consisting of aa 932-1043 of rat KCC2 (accession no. NP_599190).

Clone: S1-12

Isotype: IgG2a

Information d'application

Indications d'application: Immunoblotting: use at 3 μg/mL. A band of ~140 kDa is detected.
Immunohistochemistry: use at 1-5 μg/mL.
Positive control: Adult rat brain
These are recommended concentrations,
Enduser should determine optimal concentrations for their applications.

Restrictions: For Research Use only

Stockage

Format: Liquid

Reconstitution: Dilute in PBS or medium which is identical to that used in the assay system.

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.4, 50 % glycerol, 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: This antibody is stable for at least one (1) year at -20°C.

Détails sur SLC12A4

Antigène: SLC12A4 (Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 4 (SLC12A4))

Autre désignation: K+/Cl- Cotransporter (SLC12A4 Produits)

Synonymes: anticorps KCC1, anticorps kcc1, anticorps SLC12A4, anticorps AW546649, anticorps RBCKCC1, anticorps Kcc1, anticorps solute carrier family 12 member 4, anticorps solute carrier family 12 (potassium/chloride transporter), member 4 L homeolog, anticorps solute carrier family 12, member 4, anticorps SLC12A4, anticorps slc12a4.L, anticorps Slc12a4

Sujet: Solute carrier family 12 member 5,Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition (PubMed:9930699). Involved in the regulation of dendritic spine formation and maturation (PubMed:22345354). {PubMed:22345354, PubMed:9930699}.,KCC2 is a member of the cation-chloride cotransporter gene family. KCCs lower intracellular chloride concentrations below the electrochemical equilibrium potential. Depending on the concentration gradients of potassium and chloride, KCC2 can operate as a net efflux or influx pathway. KCC2 is expressed at high levels in neurons throughout the nervous system and is localized at inhibitory synapses of the spinal cord. Studies in mice have shown that KCC2 reduces GABA's inhibitory signaling resulting in motor defects, epilepsy, and anxiety-like behavior.,Membrane, Multi-pass membrane protein.,Electroneutral potassium-chloride cotransporter 2, Furosemide-sensitive K-Cl cotransporter, K-Cl cotransporter 2, rKCC2, Neuronal K-Cl cotransporter

NCBI Accession: NP_599190

UniProt: Q63633