PRICKLE1 anticorps (C-Term)

N° du produit ABIN1077370

Détail du produit anti-PRICKLE1 anticorps

Antigène: PRICKLE1 (Prickle-Like Protein 1 (PRICKLE1))

Épitope: C-Term

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PRICKLE1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Specificité: Multiple isoforms of PRICKLE1 are known to exist. PRICKLE1 antibody is predicted to not cross-react with other PRICKLE protein family members.

Purification: Affinity chromatography purified via peptide column

Immunogène: PRICKLE1 antibody was raised against a AA 19 synthetic peptide near the carboxy terminus of human PRICKLE1.

Isotype: IgG

Information d'application

Indications d'application: PRICKLE1 antibody can be used for detection of PRICKLE1 by Western blot at 1 μg/mL. Antibody can also be used for immunofluorescence starting at 20 μg/mL. For immunofluorescence start at 20 μg/mL. Optimal dilutions for each application to be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Stock: 4 °C/-20 °C

Stockage commentaire: PRICKLE1 antibody can be stored at 4 °C for three months and -20 °C, stable for up to one year.

Date de péremption: 12 months

Détails sur PRICKLE1

Antigène: PRICKLE1 (Prickle-Like Protein 1 (PRICKLE1))

Autre désignation: PRICKLE1 (PRICKLE1 Produits)

Synonymes: anticorps EPM1B, anticorps RILP, anticorps Rilp, anticorps 1110058P22Rik, anticorps AW215793, anticorps Prickle, anticorps mpk1, anticorps XPk, anticorps pk-B, anticorps prickle, anticorps prickle-B, anticorps Prickle-b, anticorps prickle planar cell polarity protein 1, anticorps prickle planar cell polarity protein 1 L homeolog, anticorps prickle planar cell polarity protein 1 S homeolog, anticorps PRICKLE1, anticorps Prickle1, anticorps prickle1.L, anticorps prickle1.S

Sujet: Synonyms:
REST, NRSF-interacting LIM domain protein 1, RILP, EPM1B

PRICKLE1 is a Disheveled-associated protein that serves as a nuclear translocation receptor for REST/NRSF and REST4. It contains three N-terminal LIM domains and three C-terminal nuclear localization signals. It localizes to the cytoplasm, as well as to the nuclear membrane and expressed at higher levels in placenta. PRICKLE1 is a negative regulator of the Wnt / beta-catenin signaling pathway and is a putative tumor suppressor in human HCCs. Defects in the gene encoding PRICKLE1 are associated with autosomal recessive progressive myoclonic epilepsy.

ID gène: 144165

NCBI Accession: NP_694571

Pathways: Signalisation WNT, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development, Protein targeting to Nucleus